Targeting of Aberrant mRNAs to Cytoplasmic Processing Bodies

A Threshold Selection Method from Gray-Level Histograms

1979 • 39,466 citations

Image processing with ImageJ

2004 • 11,866 citations

Localization of ASH1 mRNA Particles in Living Yeast

1998 • 1,566 citations

Stress granules and processing bodies are dynamically linked sites of mRNP remodeling

2005 • 1,403 citations

Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

2003 • 1,323 citations

Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics

2004 • 1,167 citations

Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies

2005 • 754 citations

Processing bodies require RNA for assembly and contain nontranslating mRNAs

2005 • 696 citations

A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

1993 • 660 citations

Cytoplasmic foci are sites of mRNA decay in human cells

2004 • 644 citations

General Translational Repression by Activators of mRNA Decapping

2005 • 630 citations

Binding of a novel SMG-1–Upf1–eRF1–eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

2006 • 596 citations

A faux 3′-UTR promotes aberrant termination and triggers nonsense- mediated mRNA decay

2004 • 504 citations

Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures

2002 • 464 citations

Nonsense-mediated mRNA decay: terminating erroneous gene expression

2004 • 445 citations

Premature translational termination triggers mRNA decapping

1994 • 399 citations

A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies

2005 • 389 citations

The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrn1 in distinct cytoplasmic foci

2002 • 387 citations

Nonsense-Mediated mRNA Decay in Mammalian Cells Involves Decapping, Deadenylating, and Exonucleolytic Activities

2003 • 365 citations

Identification of a Human Decapping Complex Associated with hUpf Proteins in Nonsense-Mediated Decay

2002 • 355 citations

The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes

2001 • 342 citations

An essential component of the decapping enzyme required for normal rates of mRNA turnover

1996 • 328 citations

Intron function in the nonsense-mediated decay of β-globin mRNA: Indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm

1998 • 297 citations

SMG7 Acts as a Molecular Link between mRNA Surveillance and mRNA Decay

2004 • 286 citations

Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant.

1993 • 265 citations

EJC-independent degradation of nonsense immunoglobulin-μ mRNA depends on 3′ UTR length

2006 • 253 citations

A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay

2005 • 247 citations

Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila

2004 • 241 citations

SMG7 Is a 14-3-3-like Adaptor in the Nonsense-Mediated mRNA Decay Pathway

2005 • 225 citations

SMG-2 Is a Phosphorylated Protein Required for mRNA Surveillance inCaenorhabditis elegansand Related to Upf1p of Yeast

1999 • 214 citations

Genetic and Biochemical Characterization of Mutations in the ATPase and Helicase Regions of the Upf1 Protein

1996 • 214 citations

An NMD Pathway in Yeast Involving Accelerated Deadenylation and Exosome-Mediated 3′→5′ Degradation

2003 • 212 citations

Mechanisms of mRNA Surveillance in Eukaryotes

1999 • 212 citations

Pre-mRNA processing factors are required for nuclear export

2000 • 185 citations

Identification of Edc3p as an Enhancer of mRNA Decapping inSaccharomyces cerevisiae

2004 • 156 citations

The Yeast hnRNP-like Protein Hrp1/Nab4 Marks a Transcript for Nonsense-Mediated mRNA Decay

2000 • 154 citations

Computational Modeling and Experimental Analysis of Nonsense-Mediated Decay in Yeast

2003 • 151 citations

Looking at mRNA decay pathways through the window of molecular evolution

2003 • 142 citations

Capped mRNA Degradation Intermediates Accumulate in the Yeast spb8-2 Mutant

1998 • 136 citations

Rapid Deadenylation Triggered by a Nonsense Codon Precedes Decay of the RNA Body in a Mammalian Cytoplasmic Nonsense-Mediated Decay Pathway

2003 • 135 citations

The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm.

1995 • 132 citations

Upf1p Control of Nonsense mRNA Translation Is Regulated by Nmd2p and Upf3p

2000 • 111 citations

Upf1p, Nmd2p, and Upf3p Regulate the Decapping and Exonucleolytic Degradation of both Nonsense-Containing mRNAs and Wild-Type mRNAs

2001 • 101 citations

Recognition of Yeast mRNAs as “Nonsense Containing” Leads to Both Inhibition of mRNA Translation and mRNA Degradation: Implications for the Control of mRNA Decapping

1999 • 97 citations

Interaction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeast

2003 • 81 citations

A factor required for nonsense-mediated mRNA decay in yeast is exported from the nucleus to the cytoplasm by a nuclear export signal sequence

1998 • 61 citations

β-Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon

2002 • 56 citations