Computational Modeling and Experimental Analysis of Nonsense-Mediated Decay in Yeast

A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

1993 • 660 citations

The Transcription Factor Associated Ccr4 and Caf1 Proteins Are Components of the Major Cytoplasmic mRNA Deadenylase in Saccharomyces cerevisiae

2001 • 574 citations

Evidence for a Pioneer Round of mRNA Translation

2001 • 558 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.

1995 • 515 citations

The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.

1991 • 487 citations

mRNA surveillance by the Caenorhabditis elegans smg genes.

1993 • 459 citations

Interference of nonsense mutations with eukaryotic messenger RNA stability.

1979 • 454 citations

Premature translational termination triggers mRNA decapping

1994 • 399 citations

A common function for mRNA 5' and 3' ends in translation initiation in yeast.

1995 • 374 citations

The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif

1999 • 365 citations

Turnover Mechanisms of the Stable Yeast PGK1 mRNA

1995 • 341 citations

Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex inSaccharomyces cerevisiae

2002 • 325 citations

mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor.

1993 • 307 citations

Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast.

1995 • 278 citations

Mechanisms of mRNA Surveillance in Eukaryotes

1999 • 212 citations

Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.

1993 • 200 citations

Consequences of frameshift mutations at the immunoglobulin heavy chain locus of the mouse.

1985 • 193 citations

Novel Upf2p Orthologues Suggest a Functional Link between Translation Initiation and Nonsense Surveillance Complexes

2000 • 169 citations

Mechanisms And Control Of mRNA Decapping in Saccharomyces cerevisiae

2000 • 150 citations

Characterization of cis-Acting Sequences and Decay Intermediates Involved in Nonsense-Mediated mRNA Turnover

1995 • 146 citations

Computational modeling of eukaryotic mRNA turnover

2001 • 138 citations

Nonsense-mediated mRNA decay in Saccharomyces cerevisiae

2001 • 136 citations

Premature nonsense codons decrease the stability of phytohemagglutinin mRNA in a position‐dependent manner

1996 • 115 citations

Curbing the nonsense: the activation and regulation of mRNA surveillance: Figure 1.

2001 • 105 citations

Boundary‐independent polar nonsense‐mediated decay

2002 • 99 citations

Recognition of Yeast mRNAs as “Nonsense Containing” Leads to Both Inhibition of mRNA Translation and mRNA Degradation: Implications for the Control of mRNA Decapping

1999 • 97 citations

Defects in the mRNA export factors Rat7p, Gle1p, Mex67p, and Rat8p cause hyperadenylation during 3′-end formation of nascent transcripts

2001 • 84 citations

Analysis of Mutations in the Yeast mRNA Decapping Enzyme

1999 • 76 citations

Nonsense mutations in the alcohol dehydrogenase gene of Drosophila melanogaster correlate with an abnormal 3′ end processing of the corresponding pre-mRNA

1999 • 49 citations

Accumulation of mRNA Coding for the Ctf13p Kinetochore Subunit of Saccharomyces cerevisiae Depends on the Same Factors That Promote Rapid Decay of Nonsense mRNAs

1998 • 29 citations

Characterization of a General Stabilizer Element That Blocks Deadenylation-dependent mRNA Decay

2001 • 18 citations