Novel conserved domains in proteins with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The PyMOL Molecular Graphics System

2002 • 18,218 citations

PHYLIP-Phylogeny inference package (Version 3.2)

1989 • 17,674 citations

A Simple, Fast, and Accurate Algorithm to Estimate Large Phylogenies by Maximum Likelihood

2003 • 16,546 citations

The Pfam protein families database.

2002 • 14,298 citations

SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

1997 • 10,943 citations

T-coffee: a novel method for fast and accurate multiple sequence alignment 1 1Edited by J. Thornton

2000 • 6,765 citations

The Genome Sequence of Drosophila melanogaster

2000 • 5,882 citations

Functional organization of the yeast proteome by systematic analysis of protein complexes

2002 • 4,751 citations

A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae

2000 • 4,734 citations

Global analysis of protein localization in budding yeast

2003 • 4,276 citations

A comprehensive two-hybrid analysis to explore the yeast protein interactome

2001 • 3,564 citations

Prediction of Protein Secondary Structure at Better than 70% Accuracy

1993 • 2,958 citations

TREE-PUZZLE: maximum likelihood phylogenetic analysis using quartets and parallel computing

2002 • 2,565 citations

Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

2000 • 1,767 citations

Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

2003 • 1,323 citations

Horizontal gene transfer among genomes: The complexity hypothesis

1999 • 1,173 citations

The Pfam Protein Families Database

2002 • 785 citations

Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors

1993 • 663 citations

Genome-Wide RNAi of C. elegans Using the Hypersensitive rrf-3 Strain Reveals Novel Gene Functions

2003 • 635 citations

Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.

1992 • 619 citations

Topology prediction for helical transmembrane proteins at 86% accuracy–Topology prediction at 86% accuracy

1996 • 613 citations

Crystal Structure of Escherichia coli MscS, a Voltage-Modulated and Mechanosensitive Channel

2002 • 586 citations

Non-globular domains in protein sequences: Automated segmentation using complexity measures

1994 • 537 citations

Comparative genomics and evolution of proteins involved in RNA metabolism

2002 • 524 citations

Weighted Neighbor Joining: A Likelihood-Based Approach to Distance-Based Phylogeny Reconstruction

2000 • 496 citations

Crystal Structures of Two Sm Protein Complexes and Their Implications for the Assembly of the Spliceosomal snRNPs

1999 • 467 citations

Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches

1999 • 446 citations

Yeast Sm-like proteins function in mRNA decapping and decay

2000 • 434 citations

Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein

2002 • 431 citations

Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain

2000 • 426 citations

A Sm-like protein complex that participates in mRNA degradation

2000 • 390 citations

The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrn1 in distinct cytoplasmic foci

2002 • 387 citations

The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif

1999 • 365 citations

Evolution and Classification of P-loop Kinases and Related Proteins

2003 • 302 citations

Comparative Genomics of the Archaea (Euryarchaeota): Evolution of Conserved Protein Families, the Stable Core, and the Variable Shell

1999 • 270 citations

Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle

1999 • 268 citations

Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin

1999 • 266 citations

Prediction of the Archaeal Exosome and Its Connections with the Proteasome and the Translation and Transcription Machineries by a Comparative-Genomic Approach

2001 • 251 citations

The snRNP core assembly pathway: identification of stable core protein heteromeric complexes and an snRNP subcore particle in vitro.

1996 • 238 citations

Arginine/serine-rich domains of the su(wa) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicing

1991 • 224 citations

Sm-like proteins in Eubacteria: the crystal structure of the Hfq protein from Escherichia coli

2003 • 212 citations

PCMA: fast and accurate multiple sequence alignment based on profile consistency

2003 • 183 citations

Novel Predicted RNA-Binding Domains Associated with the Translation Machinery

1999 • 182 citations

RNA binding in an Sm core domain: X-ray structure and functional analysis of an archaeal Sm protein complex

2001 • 170 citations

SPOUT: a class of methyltransferases that includes spoU and trmD RNA methylase superfamilies, and novel superfamilies of predicted prokaryotic RNA methylases.

2002 • 137 citations

The Sm domain is an ancient RNA-binding motif with oligo(U) specificity

2001 • 126 citations

G-quartet-dependent recognition between the FMRP RGG box and RNA

2003 • 121 citations

Crystal Structures of the Pyrococcus abyssi Sm Core and Its Complex with RNA

2003 • 110 citations

Archaeal RNase P has multiple protein subunits homologous to eukaryotic nuclear RNase P proteins

2002 • 102 citations

The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme

2003 • 84 citations

THUMP – a predicted RNA-binding domain shared by 4-thiouridine, pseudouridine synthases and RNA methylases

2001 • 82 citations

Archaeal Sm Proteins form Heptameric and Hexameric Complexes: Crystal Structures of the Sm1 and Sm2 Proteins from the Hyperthermophile Archaeoglobus fulgidus

2002 • 80 citations

A Biochemical Function for the Sm Complex

2001 • 70 citations

TRAM, a predicted RNA-binding domain, common to tRNA uracil methylation and adenine thiolation enzymes

2001 • 68 citations

Structure and assembly of an augmented Sm-like archaeal protein 14-mer

2003 • 55 citations

Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing

2003 • 55 citations

Ataxin-2, global regulators and bacterial gene expression, and spliceosomal snRNP proteins share a conserved domain

1997 • 42 citations

Untitled

1998 • 39 citations

Suppressors of Cdc25p Overexpression Identify Two Pathways That Influence the G2/M Checkpoint in Fission Yeast

1998 • 39 citations

Identification of a Novel mRNA-Associated Protein in Oocytes ofPleurodeles waltlandXenopus laevis

1998 • 38 citations

The PWI motif: a new protein domain in splicing factors

1999 • 28 citations

SWAP pre-mRNA splicing regulators are a novel, ancient protein family sharing a highly conserved sequence motif with the prp21 family of constitutive splicing proteins

1994 • 27 citations

Solution structure and function of a conserved protein SP14.3 encoded by an essential Streptococcus pneumoniae gene 1 1Edited by M. F. Summers

2001 • 22 citations

An EVH1/WH1 domain as a key actor in TGFβ signalling

2002 • 19 citations