Live imaging of nuage and polar granules: evidence against a precursor-product relationship and a novel role for Oskar in stabilization of polar granule components

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

The Genetics and Biology of Drosophila

1978 • 3,910 citations

An Electron Microscopic Study

1987 • 1,144 citations

oskar organizes the germ plasm and directs localization of the posterior determinant nanos

1991 • 804 citations

Induction of germ cell formation by oskar

1992 • 643 citations

Regulation of zygotic gene expression in Drosophila primordial germ cells

1998 • 643 citations

The product of the Drosophila gene vasa is very similar to eukaryotic initiation factor-4A

1988 • 625 citations

Germ Plasm and the Differentiation of the Germ Cell Line

1976 • 612 citations

A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases

1988 • 602 citations

oskar mRNA is localized to the posterior pole of the Drosophila oocyte

1991 • 574 citations

Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology.

1991 • 504 citations

Implications for bcd mRNA localization from spatial distribution of exu protein in Drosophila oogenesis

1994 • 482 citations

Abdominal segmentation, pole cell formation, and embryonic polarity require the localized activity of oskar, a maternal gene in drosophila

1986 • 463 citations

Translational regulation of oskar mRNA by Bruno, an ovarian RNA-binding protein, is essential

1995 • 451 citations

Maternal-effect mutations altering the anterior-posterior pattern of the Drosophila embryo

1986 • 449 citations

Posterior localization of vasa protein correlates with, but is not sufficient for, pole cell development.

1990 • 374 citations

The maternal gene nanos has a central role in posterior pattern formation of the Drosophila embryo

1991 • 349 citations

The function and regulation of vasa-like genes in germ-cell development.

2000 • 333 citations

Localization of vasa protein to the Drosophila pole plasm is independent of its RNA-binding and helicase activities

1994 • 328 citations

aubergineencodes aDrosophilapolar granule component required for pole cell formation and related to eIF2C

2001 • 321 citations

vasa is required for GURKEN accumulation in the oocyte, and is involved in oocyte differentiation and germline cyst development

1998 • 292 citations

Germline development in vertebrates and invertebrates

1999 • 274 citations

Fine structure of pole cells and polar granules in Drosophila melanogaster

1962 • 274 citations

Polar granules of Drosophila. II. Ultrastructural changes during early embryogenesis

1968 • 250 citations

Identification of a component ofDrosophilapolar granules

1988 • 247 citations

Assembly of the Drosophila germ plasm

2001 • 245 citations

Translational control of oskar generates Short OSK, the isoform that induces pole plasm assembly

1995 • 243 citations

Maelstrom, aDrosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage

2003 • 233 citations

Oskar protein interaction with Vasa represents an essential step in polar granule assembly.

1996 • 222 citations

Localization of vasa, a component of Drosophila polar granules, in maternal-effect mutants that alter embryonic anteroposterior polarity

1990 • 215 citations

Translational repressorbruno plays multiple roles in development and is widely conserved

1997 • 213 citations

Localization of oskar RNA regulates oskar translation and requires Oskar protein

1995 • 208 citations

Overexpression of oskar directs ectopic activation of nanos and presumptive pole cell formation in Drosophila embryos

1992 • 205 citations

INTERCELLULAR MIGRATION OF CENTRIOLES IN THE GERMARIUM OF DROSOPHILA MELANOGASTER

1970 • 201 citations

In Vivo Analysis of Drosophila bicoid mRNA Localization Reveals a Novel Microtubule-Dependent Axis Specification Pathway

2001 • 194 citations

Kinesin light chain-independent function of theKinesin heavy chainin cytoplasmic streaming and posterior localisation in theDrosophilaoocyte

2002 • 192 citations

Oocyte polarity depends on regulation of gurken by Vasa

1998 • 188 citations

The fat facets gene is required for Drosophila eye and embryo development

1992 • 187 citations

RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E

2002 • 184 citations

aubergine enhances oskar translation in the Drosophila ovary

1996 • 164 citations

Cytoplasmic flows localize injected oskar RNA in Drosophila oocytes

1997 • 163 citations

Polar granules of Drosophila. III. The continuity of polar granules during the life cycle of Drosophila

1971 • 156 citations

Homeless is required for RNA localization in Drosophila oogenesis and encodes a new member of the DE-H family of RNA-dependent ATPases.

1995 • 156 citations

Oskar anchoring restricts pole plasm formation to the posterior of theDrosophilaoocyte

2002 • 147 citations

Distribution of tudor protein in the Drosophila embryo suggests separation of functions based on site of localization

1993 • 136 citations

In vivo analyses of cytoplasmic transport and cytoskeletal organization during Drosophila oogenesis: characterization of a multi-step anterior localization pathway

1998 • 133 citations

A Sponge-like Structure Involved in the Association and Transport of Maternal Products during Drosophila Oogenesis

1997 • 125 citations

Identification of a transcriptional regulatory region for germline-specific expression of vasa gene in Drosophila melanogaster

2002 • 85 citations

maelstrom is required for an early step in the establishment of Drosophila oocyte polarity: posterior localization of grk mRNA

1997 • 84 citations

Ultrastructural studies of spermatogenesis in Drosophila melanogaster meigen

1973 • 84 citations

VASA Localization Requires the SPRY-Domain and SOCS-Box Containing Protein, GUSTAVUS

2002 • 77 citations

Bruno regulates gurken during Drosophila oogenesis

2003 • 76 citations

Par-1 regulates stability of the posterior determinant Oskar by phosphorylation

2002 • 71 citations

Cytoskeleton-dependent transport of cytoplasmic particles in previtellogenic to mid-vitellogenic ovarian follicles of Drosophila: time-lapse analysis using video-enhanced contrast microscopy

1994 • 52 citations

Drosophila virilis oskar transgenes direct body patterning but not pole cell formation or maintenance of mRNA localization in D. melanogaster

1994 • 43 citations

Requirement for the Vasa RNA Helicase ingurkenmRNA Localization

1998 • 38 citations

Ultrastructural observations on the degenerating nurse cells of late ovarian chambers of Drosophila melanogaster.

1976 • 5 citations