Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila

Killing the messenger: short RNAs that silence gene expression

2003 • 1,197 citations

The cap-to-tail guide to mRNA turnover

2001 • 759 citations

Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs)

2003 • 530 citations

Characterization and use of theDrosophilametallothionein promoter in culturedDrosophila melanogastercells

1988 • 440 citations

Premature translational termination triggers mRNA decapping

1994 • 399 citations

Nonsense-Mediated mRNA Decay in Mammalian Cells Involves Decapping, Deadenylating, and Exonucleolytic Activities

2003 • 365 citations

Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening.

1994 • 290 citations

Nonsense-mediated mRNA decay in Drosophila:at the intersection of the yeast and mammalian pathways

2003 • 284 citations

mRNA surveillance: the perfect persist

2002 • 229 citations

Aberrant mRNAs with extended 3′ UTRs are substrates for rapid degradation by mRNA surveillance

1999 • 226 citations

An NMD Pathway in Yeast Involving Accelerated Deadenylation and Exosome-Mediated 3′→5′ Degradation

2003 • 212 citations

Cleavage of the A Site mRNA Codon during Ribosome Pausing Provides a Mechanism for Translational Quality Control

2003 • 211 citations

A Novel Phosphorylation-Dependent RNase Activity of GAP-SH3 Binding Protein: a Potential Link between Signal Transduction and RNA Stability

1998 • 195 citations

Computational Modeling and Experimental Analysis of Nonsense-Mediated Decay in Yeast

2003 • 151 citations

Characterization of cis-Acting Sequences and Decay Intermediates Involved in Nonsense-Mediated mRNA Turnover

1995 • 146 citations

Rapid Deadenylation Triggered by a Nonsense Codon Precedes Decay of the RNA Body in a Mammalian Cytoplasmic Nonsense-Mediated Decay Pathway

2003 • 135 citations

Degradation of apolipoprotein II mRNA occurs via endonucleolytic cleavage at 5′-AAU-3′/5′-UAA-3′ elements in single-stranded loop domains of the 3′-noncoding region

1989 • 118 citations

Upf1p, Nmd2p, and Upf3p Regulate the Decapping and Exonucleolytic Degradation of both Nonsense-Containing mRNAs and Wild-Type mRNAs

2001 • 101 citations

Nascent-peptide-mediated ribosome stalling at a stop codon induces mRNA cleavage resulting in nonstop mRNA that is recognized by tmRNA

2004 • 95 citations

Human beta-globin mRNAs that harbor a nonsense codon are degraded in murine erythroid tissues to intermediates lacking regions of exon I or exons I and II that have a cap-like structure at the 5′ termini.

1992 • 90 citations

Vigilin binding selectively inhibits cleavage of the vitellogenin mRNA 3′-untranslated region by the mRNA endonuclease polysomal ribonuclease 1

2000 • 88 citations

Identification of an erythroid-enriched endoribonuclease activity involved in specific mRNA cleavage

2000 • 84 citations

Endonucleolytic cleavage of a maternal homeo box mRNA in Xenopus oocytes.

1990 • 75 citations

Purification and Characterization of a Polysome-associated Endoribonuclease That Degrades c-myc mRNA in Vitro

1998 • 70 citations

β-Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon

2002 • 56 citations

Long-Range RNA Interaction of Two Sequence Elements Required for Endonucleolytic Cleavage of Human Insulin-Like Growth Factor II mRNAs

1995 • 55 citations

A polysomal ribonuclease involved in the destabilization of albumin mRNA is a novel member of the peroxidase gene family

1998 • 51 citations

The Drosophila Gene for Antizyme Requires Ribosomal Frameshifting for Expression and Contains an Intronic Gene for snRNP Sm D3 on the Opposite Strand

1998 • 35 citations

An endonuclease activity similar to Xenopus PMR1 catalyzes the degradation of normal and nonsense-containing human β-globin mRNA in erythroid cells

2003 • 32 citations

Identification of RNA sequences and structures involved in site-specific cleavage of IGF-II mRNAs

1998 • 20 citations