Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

The nuclear RNase III Drosha initiates microRNA processing

2003 • 4,966 citations

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

2005 • 4,706 citations

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1993 • 4,021 citations

miR-15 and miR-16 induce apoptosis by targeting BCL2

2005 • 3,424 citations

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

2000 • 2,945 citations

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

2003 • 2,893 citations

Nuclear Export of MicroRNA Precursors

2003 • 2,662 citations

The Microprocessor complex mediates the genesis of microRNAs

2004 • 2,625 citations

Argonaute2 Is the Catalytic Engine of Mammalian RNAi

2004 • 2,620 citations

Processing of primary microRNAs by the Microprocessor complex

2004 • 2,617 citations

Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA

2005 • 2,470 citations

MicroRNA biogenesis: coordinated cropping and dicing

2005 • 2,443 citations

Principles of MicroRNA–Target Recognition

2005 • 2,335 citations

microRNA-Directed Phasing during Trans-Acting siRNA Biogenesis in Plants

2005 • 2,175 citations

The Drosha-DGCR8 complex in primary microRNA processing

2004 • 2,096 citations

A pancreatic islet-specific microRNA regulates insulin secretion

2004 • 2,054 citations

bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila

2003 • 2,012 citations

Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs

2004 • 1,887 citations

A MicroRNA as a Translational Repressor of APETALA2 in Arabidopsis Flower Development

2003 • 1,694 citations

MicroRNA-Directed Cleavage of HOXB8 mRNA

2004 • 1,680 citations

Specificity of microRNA target selection in translational repression

2004 • 1,631 citations

Cleavage of Scarecrow-like mRNA Targets Directed by a Class of Arabidopsis miRNA

2002 • 1,569 citations

Human RISC Couples MicroRNA Biogenesis and Posttranscriptional Gene Silencing

2005 • 1,527 citations

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

2001 • 1,430 citations

Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

2005 • 1,408 citations

Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity

2004 • 1,406 citations

Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs

2004 • 1,406 citations

Stress granules and processing bodies are dynamically linked sites of mRNP remodeling

2005 • 1,403 citations

Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

2003 • 1,323 citations

Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation

2005 • 1,311 citations

siRNAs can function as miRNAs

2003 • 1,252 citations

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

2005 • 1,210 citations

The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation

1999 • 1,174 citations

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

2002 • 1,081 citations

Regulation of cap-dependent translation by eIF4E inhibitory proteins

2005 • 944 citations

MicroRNA Directs mRNA Cleavage of the Transcription Factor NAC1 to Downregulate Auxin Signals for Arabidopsis Lateral Root Development

2005 • 944 citations

MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

2003 • 915 citations

The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis

2002 • 874 citations

Involvement of MicroRNA in AU-Rich Element-Mediated mRNA Instability

2005 • 848 citations

Targeted mRNA degradation by double-stranded RNA in vitro

1999 • 845 citations

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways

2004 • 831 citations

The Human DiGeorge Syndrome Critical Region Gene 8 and Its D. melanogaster Homolog Are Required for miRNA Biogenesis

2004 • 815 citations

The enzymes and control of eukaryotic mRNA turnover

2004 • 793 citations

A combined computational-experimental approach predicts human microRNA targets

2004 • 776 citations

Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies

2005 • 754 citations

Purified Argonaute2 and an siRNA form recombinant human RISC

2005 • 736 citations

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

2004 • 717 citations

Processing bodies require RNA for assembly and contain nontranslating mRNAs

2005 • 696 citations

MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5′ region

2004 • 685 citations

A role for the P-body component GW182 in microRNA function

2005 • 670 citations

Fragile X-related protein and VIG associate with the RNA interference machinery

2002 • 646 citations

Cytoplasmic foci are sites of mRNA decay in human cells

2004 • 644 citations

MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

2005 • 642 citations

Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies

2005 • 631 citations

General Translational Repression by Activators of mRNA Decapping

2005 • 630 citations

Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

2005 • 629 citations

A Protein Sensor for siRNA Asymmetry

2004 • 584 citations

A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins

2002 • 573 citations

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes

2003 • 569 citations

The Molecular Mechanics of Eukaryotic Translation

2004 • 541 citations

Kinetic analysis of the RNAi enzyme complex

2004 • 537 citations

A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

2005 • 491 citations

Disruption of GW bodies impairs mammalian RNA interference

2005 • 487 citations

Eukaryotic mRNA Decapping

2004 • 476 citations

A micrococcal nuclease homologue in RNAi effector complexes

2003 • 451 citations

Small RNAs with Imperfect Match to Endogenous mRNA Repress Translation

2003 • 430 citations

RISC is a 5′ phosphomonoester-producing RNA endonuclease

2004 • 409 citations

Two Genetic Circuits Repress the Caenorhabditis elegans Heterochronic Gene lin-28 after Translation Initiation

2002 • 397 citations

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis

2004 • 390 citations

A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies

2005 • 389 citations

RNase III enzymes and the initiation of gene silencing

2004 • 387 citations

AtXRN4 Degrades mRNA in Arabidopsis and Its Substrates Include Selected miRNA Targets

2004 • 372 citations

Drosophila Cup Is an eIF4E Binding Protein that Associates with Bruno and Regulates oskar mRNA Translation in Oogenesis

2004 • 362 citations

Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome

2005 • 337 citations

Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex duringDrosophilaoogenesis

2001 • 327 citations

The Developmental Timing Regulator AIN-1 Interacts with miRISCs and May Target the Argonaute Protein ALG-1 to Cytoplasmic P Bodies in C. elegans

2005 • 268 citations

A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay

2005 • 247 citations

Mutations in Translation Initiation Factors Lead to Increased Rates of Deadenylation and Decapping of mRNAs in Saccharomyces cerevisiae

1999 • 240 citations

A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation.

1996 • 235 citations

Substrate requirements for let-7 function in the developing zebrafish embryo

2016 • 219 citations

Substrate requirements for let-7 function in the developing zebrafish embryo

2004 • 205 citations

Uridine Addition After MicroRNA-Directed Cleavage

2004 • 198 citations

Computational Modeling and Experimental Analysis of Nonsense-Mediated Decay in Yeast

2003 • 151 citations

The role of the AU-rich elements of mRNAs in controlling translation

2004 • 125 citations

Loss of Translational Control in Yeast Compromised for the Major mRNA Decay Pathway

2004 • 98 citations

Virus-like particles of the Ty3 retrotransposon assemble in association with P-body components

2005 • 97 citations

Novel modes of protein–RNA recognition in the RNAi pathway

2005 • 92 citations

The 5′–3′ exoribonuclease xrn-1 is essential for ventral epithelial enclosure during C. elegans embryogenesis

2003 • 58 citations

Mutations in VPS16 and MRT1 Stabilize mRNAs by Activating an Inhibitor of the Decapping Enzyme

1999 • 36 citations

Inhibition of mRNA deadenylation and degradation by ultraviolet light

2005 • 36 citations

Deleted Work

1955 • 0 citations