NF-IL6 and NF-kappa B in cytokine gene regulation.

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

1994 • 2,037 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

1991 • 1,684 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.

1993 • 1,077 citations

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor.

1994 • 1,057 citations

A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the sam mRNA

1991 • 1,019 citations

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

1994 • 1,015 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

Isolation of a recombinant copy of the gene encoding C/EBP.

1988 • 1,003 citations

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.

1993 • 955 citations

Impaired Energy Homeostasis in C/EBPα Knockout Mice

1995 • 925 citations

Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins.

1995 • 922 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

1993 • 884 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

Characterization of Mechanisms Involved in Transrepression of NF-κB by Activated Glucocorticoid Receptors

1995 • 815 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

1991 • 746 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

CCAAT-Enhancer Binding Protein: A Component of a Differentiation Switch

1991 • 733 citations

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.

1989 • 698 citations

Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ

1995 • 692 citations

Transcriptional Roles of Nuclear Factor κB and Nuclear Factor-Interleukin-6 in the Tumor Necrosis Factor α-Dependent Induction of Cyclooxygenase-2 in MC3T3-E1 Cells

1995 • 657 citations

Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.

1990 • 642 citations

Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein.

1989 • 641 citations

IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to CEBP

1990 • 637 citations

Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses.

1987 • 631 citations

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.

1993 • 621 citations

A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro.

1991 • 604 citations

DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide

1991 • 604 citations

LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein.

1990 • 599 citations

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.

1993 • 587 citations

Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes.

1989 • 587 citations

Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level.

1993 • 543 citations

Regulation of the NF-ηB/rel transcription factor and IηB inhibitor system

1993 • 541 citations

IL‐6 and NF‐IL6 in Acute‐Phase Response and Viral Infection

1992 • 540 citations

Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages

1995 • 532 citations

Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction.

1993 • 530 citations

Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis.

1995 • 527 citations

A Macrophage Factor Inhibits Adipocyte Gene Expression: An in Vitro Model of Cachexia

1985 • 525 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers

1993 • 506 citations

Selection of Optimal κB/Rel DNA-Binding Motifs: Interaction of Both Subunits of NF-κB with DNA Is Required for Transcriptional Activation

1992 • 501 citations

CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells.

1989 • 488 citations

Transcriptional Regulation of Human Prostaglandin-endoperoxide Synthase-2 Gene by Lipopolysaccharide and Phorbol Ester in Vascular Endothelial Cells

1995 • 487 citations

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.

1995 • 477 citations

The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control

1990 • 469 citations

Molecular mechanism of interleukin-8 gene expression

1994 • 465 citations

Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells.

1994 • 450 citations

Cloning and Characterization of Subunits of the T-Cell Receptor and Murine Leukemia Virus Enhancer Core-Binding Factor

1993 • 425 citations

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice.

1995 • 418 citations

A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells

1992 • 413 citations

Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65

1991 • 410 citations

B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50

1991 • 403 citations

CCAAT Enhancer-Binding Protein (C/EBP) and AML1 (CBFα2) Synergistically Activate the Macrophage Colony-Stimulating Factor Receptor Promoter

1996 • 399 citations

Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPβ

1992 • 398 citations

CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein.

1996 • 393 citations

cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription.

1991 • 388 citations

RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.

1992 • 375 citations

Proteasomes: destruction as a programme

1996 • 373 citations

Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha.

1991 • 369 citations

NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site.

1994 • 363 citations

Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB

1995 • 351 citations

Induction of Interleukin 6 (IL-6) by Hypoxia in Vascular Cells

1995 • 348 citations

IκBα Deficiency Results in a Sustained NF-κB Response and Severe Widespread Dermatitis in Mice

1996 • 347 citations

Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain

1993 • 345 citations

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

1994 • 331 citations

A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.

1992 • 327 citations

Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 (RelA) and NF-IL-6.

1994 • 327 citations

Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide.

1994 • 325 citations

The candidate oncoprotein Bcl-3 is an antagonist of pSO/NF-κB-mediated inhibition

1992 • 325 citations

Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes.

1992 • 324 citations

The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor.

1992 • 324 citations

Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response.

1992 • 313 citations

The ets gene family

1992 • 308 citations

Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor.

1994 • 307 citations

Stress-Induced Binding of the Transcription Factor CHOP to a Novel DNA Control Element

1996 • 305 citations

B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching.

1996 • 304 citations

Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6

1992 • 299 citations

Reciprocal Regulation of Adipogenesis by Myc and C/EBPα

1992 • 296 citations

Nucleic acid sequences of the oncogene v-rel in reticuloendotheliosis virus strain T and its cellular homolog, the proto-oncogene c-rel

1984 • 295 citations

PU.1 (Spi-1) and C/EBPα Regulate Expression of the Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Gene

1995 • 287 citations

Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene.

1990 • 283 citations

A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site.

1992 • 281 citations

Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types.

1993 • 275 citations

Sequential Induction of NF-κB/Rel Family Proteins during B-Cell Terminal Differentiation

1994 • 275 citations

IκBγ, a 70 kd protein identical to the C-terminal half of p110 NF-κB: A new member of the IκB family

1992 • 274 citations

Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family.

1990 • 274 citations

Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP.

1990 • 272 citations

Is CCAAT/enhancer-binding protein a central regulator of energy metabolism?

1989 • 266 citations

Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

1995 • 258 citations

Rel-Associated pp40: an Inhibitor of the Rel Family of Transcription Factors

1991 • 255 citations

The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein.

1994 • 250 citations

Stimulation of Hepatic Acute Phase Response by Cytokines and Glucocorticoids^a

1989 • 242 citations

Transcriptional regulation of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Evidence for the role of a cis-acting C/EBP beta promoter element.

1993 • 234 citations

Novel mechanism of C/EBP beta (NF-M) transcriptional control: activation through derepression.

1994 • 225 citations

Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor kB and CCAAT/enhancer-binding protein-like cis-elements

1991 • 224 citations

Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1.

1994 • 217 citations

A Nuclear Factor for Interleukin-6 Expression (NF-IL6) and the Glucocorticoid Receptor Synergistically Activate Transcription of the Rat α1-Acid Glycoprotein Gene via Direct Protein-Protein Interaction

1993 • 215 citations

Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6.

1996 • 213 citations

Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region.

1994 • 207 citations

Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription factors.

1993 • 198 citations

The NF-M transcription factor is related to C/EBP beta and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells.

1993 • 195 citations

Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-kappa B.

1994 • 194 citations

The role of NF-kappa B and NF-IL6 transactivating factors in the synergistic activation of human serum amyloid A gene expression by interleukin-1 and interleukin-6.

1993 • 192 citations

Relative roles of CCAAT/enhancer-binding protein beta and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP).

1993 • 190 citations

The human prointerleukin 1 beta gene requires DNA sequences both proximal and distal to the transcription start site for tissue-specific induction.

1993 • 180 citations

A family of constitutive C/EBP-like DNA binding proteins attenuate the IL-1 alpha induced, NF kappa B mediated trans-activation of the angiotensinogen gene acute-phase response element.

1990 • 180 citations

Enhanced I kappa B alpha degradation is responsible for constitutive NF-kappa B activity in mature murine B-cell lines.

1994 • 178 citations

The NF-kappa B p50 precursor, p105, contains an internal I kappa B-like inhibitor that preferentially inhibits p50.

1992 • 178 citations

The two C/EBP isoforms, IL6DBP/NFIL6 and CEBP6δ/NFIL63, are induced by IL6β to promote acute phase gene transcription via different mechanisms

1993 • 176 citations

C/EBP proteins activate transcription from the human immunodeficiency virus type 1 long terminal repeat in macrophages/monocytes

1995 • 174 citations

C/EBP beta regulation of the tumor necrosis factor alpha gene.

1994 • 173 citations

Multiple liver-specific factors bind to the hepatitis B virus core/pregenomic promoter: trans-activation and repression by CCAAT/enhancer binding protein.

1990 • 162 citations

The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development.

1991 • 161 citations

Requirement for nuclear factor (NF)-kappa B p65 and NF-interleukin-6 binding elements in the tumor necrosis factor response region of the granulocyte colony-stimulating factor promoter

1994 • 157 citations

Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin 1 beta gene.

1994 • 156 citations

Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP).

1992 • 149 citations

Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor.

1996 • 147 citations

Dorsoventral pattern formation in Drosophila: signal transduction and nuclear targeting

1991 • 141 citations

Three levels of functional interaction determine the activity of CCAAT/enhancer binding protein-alpha on the serum albumin promoter.

1994 • 138 citations

Inhibition of transcription factors belonging to the rel/NF-kappa B family by a transdominant negative mutant.

1991 • 138 citations

Participation of the transcription factor C/EBP delta in the acute-phase regulation of the human gene for complement component C3.

1993 • 136 citations

Inhibition of cell proliferation by C/EBPα occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen

1995 • 133 citations

Regulation of the interleukin-1 beta (IL-1 beta) gene by mycobacterial components and lipopolysaccharide is mediated by two nuclear factor-IL6 motifs.

1993 • 131 citations

Isolation, characterization and chromosomal localization of the human GADD153 gene

1992 • 130 citations

Developmentally and hormonally regulated CCAAT/enhancer-binding protein isoforms influence beta-casein gene expression.

1995 • 128 citations

Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBP beta (NF-IL6) activity by p53 species

1993 • 123 citations

Regulatory elements responsible for inducible expression of the granulocyte colony-stimulating factor gene in macrophages.

1990 • 122 citations

Growth Hormone Induction of Hepatic Serine Protease Inhibitor 2.1 Transcription Is Mediated by a Stat5-related Factor Binding Synergistically to Two γ-Activated Sites

1995 • 118 citations

Cloning of the chromosome translocation breakpoint junction of the t(14;19) in chronic lymphocytic leukemia.

1987 • 118 citations

Promoter Analysis of Human Inducible Nitric Oxide Synthase Gene Associated with Cardiovascular Homeostasis

1994 • 118 citations

A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBP beta and an Sp1 factor.

1994 • 117 citations

Synergistic activation of intercellular adhesion molecule 1 (ICAM‐1) by TNF‐α and IFN‐γ is mediated by p65/p50 and p65/c‐Rel and interferon‐responsive factor Statlα (p91) that can be activated by both IFN‐γ and IFN‐α

1994 • 115 citations

Concerted Participation of NF-κB and C/EBP Heteromer in Lipopolysaccharide Induction of Serum Amyloid A Gene Expression in Liver

1995 • 114 citations

Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3).

1995 • 111 citations

NF-IL6-mediated transcriptional activation of the long terminal repeat of the human immunodeficiency virus type 1.

1993 • 111 citations

Roles of CCAAT/enhancer-binding protein and its binding site on repression and derepression of acetyl-CoA carboxylase gene.

1994 • 103 citations

Transcription Stimulation of the Fas-encoding Gene by Nuclear Factor for Interleukin-6 Expression upon Influenza Virus Infection

1995 • 103 citations

trans-activation of the alpha 1-acid glycoprotein gene acute phase responsive element by multiple isoforms of C/EBP and glucocorticoid receptor

1993 • 102 citations

NF-IL6, a member of the C/EBP family of transcription factors, binds and trans-activates the human MDR1 gene promoter.

1994 • 99 citations

Interleukin-1: a gene expression system regulated at multiple levels.

1994 • 98 citations

NF-M (chicken C/EBP beta) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line.

1995 • 97 citations

Malignant transformation by mutant Rel proteins

1991 • 96 citations

Interaction of C/EBPβ and v-Myb Is Required for Synergistic Activation of the mim-1 Gene

1996 • 96 citations

NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A

1992 • 95 citations

Molecular characterization of transcription factors that bind to the cAMP responsive region of the substance P precursor gene. cDNA cloning of a novel C/EBP-related factor

1991 • 92 citations

HTLV-1 tax activation of the GM-CSF and G-CSF promoters requires the interaction of NF-kB with other transcription factor families.

1993 • 87 citations

Early responses of trans-activating factors to growth hormone in preadipocytes: differential regulation of CCAAT enhancer-binding protein-beta (C/EBP beta) and C/EBP delta.

1995 • 86 citations

C/EBP-related protein 2 confers lipopolysaccharide-inducible expression of interleukin 6 and monocyte chemoattractant protein 1 to a lymphoblastic cell line.

1994 • 85 citations

Nuclear factor-IL6 activates the human IL-4 promoter in T cells.

1995 • 85 citations

Casein Kinase II Phosphorylation Site Mutations in c-Myb Affect DNA Binding and Transcriptional Cooperativity with NF-M

1995 • 85 citations

CCAAT/Enhancer-binding Protein Isoforms γ and δ Are Expressed in Mammary Epithelial Cells and Bind to Multiple Sites in the β-Casein Gene Promoter

1995 • 84 citations

Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: possible involvement of NF-IL6 in acute phase protein gene expression.

1991 • 83 citations

Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1, CCAAT/enhancer-binding protein alpha, liver activator protein, and D-element-binding protein.

1992 • 83 citations

NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1.

1994 • 82 citations

Promoter Structure and Transcriptional Activation of the Murine TSG-14 Gene Encoding a Tumor Necrosis Factor/Interleukin-1-inducible Pentraxin Protein

1995 • 78 citations

Induction of the mouse serum amyloid A3 gene by cytokines requires both C/EBP family proteins and a novel constitutive nuclear factor.

1994 • 78 citations

Cooperative effects of C/EBP-like and NFxB-like binding sites on rat serum amyloid A1 gene expression in liver cells

1992 • 73 citations

Expression of the insulin-like growth factor I gene is stimulated by the liver-enriched transcription factors C/EBP alpha and LAP.

1994 • 71 citations

Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the α₁-fetoprotein gene. Further analysis of C/EBPβ and C/EBPγ

1992 • 69 citations

Impaired proliferation and tumorigenicity induced by CCAAT/enhancer-binding protein.

1996 • 65 citations

MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells

1994 • 60 citations

cAMP Activation of CAAT Enhancer-binding Protein-β Gene Expression and Promoter I of Acetyl-CoA Carboxylase

1995 • 58 citations

CCAAT/enhancer binding protein expression is rapidly extinguished in TA1 adipocyte cells treated with tumor necrosis factor.

1992 • 56 citations

NF-IL6 represses early gene expression of human papillomavirus type 16 through binding to the noncoding region

1993 • 54 citations

C/EBP-like proteins binding to the functional box-alpha and box-beta of the second enhancer of hepatitis B virus.

1991 • 52 citations

NF-κB and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines

1994 • 51 citations

Binding and Functional Effects of Transcriptional Factor Sp1 on the Murine Interleukin-6 Promotor

1996 • 51 citations

The role of the p50 and p65 subunits of NF-kappa B in the recognition of cognate sequences.

1991 • 51 citations

The CCAAT/enhancer binding protein (C/EBPα) gene (CEBPA) maps to human chromosome 19q13.1 and the related nuclear factor NF-IL6 (C/EBPβ) gene (CEBPB) maps to human chromosome 20q13.1

1992 • 50 citations

C/EBPbeta is a negative regulator of human papillomavirus type 11 in keratinocytes

1996 • 48 citations

Limited expression of C/EBP family proteins during B lymphocyte development. Negative regulator Ig/EBP predominates early and activator NF-IL-6 is induced later.

1994 • 46 citations

The far upstream chicken lysozyme enhancer at -6.1 kilobase, by interacting with NF-M, mediates lipopolysaccharide-induced expression of the chicken lysozyme gene in chicken myelomonocytic cells.

1994 • 43 citations

Three Essential Promoter Elements Mediate Tumour Necrosis Factor and Interleukin-1 Activation of the Granulocyte-Colony Stimulating Factor Gene

1992 • 40 citations

LAP (NF-IL6) transactivates the collagen alpha 1(I) gene from a 5' regulatory region.

1994 • 40 citations

CCAAT Box Enhancer Binding Protein α (C/EBP-α) Stimulates B Element-mediated Transcription in Transfected Cells

1996 • 40 citations

Mutation of the C/EBP binding sites in the Rous sarcoma virus long terminal repeat and gag enhancers

1993 • 40 citations

Molecular cloning of cDNA and a chromosomal gene encoding GPE1‐BP, a nuclear protein which binds to granulocyte colony‐stimulating factor promoter element 1

1991 • 39 citations

CCAAT/enhancer-binding protein-related proteins bind to the unusual promoter of the aspartate aminotransferase housekeeping gene.

1993 • 39 citations

Regulation of two rat serine‐protease inhibitor gene promoters by somatotropin and glucocorticoids

1992 • 38 citations

CCAAT/enhancer binding protein alpha (C/EBP alpha) undifferentiated protein: a developmentally regulated nuclear protein that binds to the C/EBP alpha gene promoter.

1993 • 37 citations

CArG, CCAAT, and CCAAT-like protein binding sites in avian retrovirus long terminal repeat enhancers

1992 • 36 citations

Augmentation of haptoglobin production in Hep3B cell line by a nuclear factor NF‐IL6

1991 • 36 citations

Functional NF-IL6/CCAAT enhancer-binding protein is required for tumor necrosis factor alpha-inducible expression of the granulocyte colony-stimulating factor (CSF), but not the granulocyte/macrophage CSF or interleukin 6 gene in human fibroblasts.

1995 • 35 citations

Constitutive and IL－1 inducible factors interact with the IL-1 responsive element in the IL-6 gene

1992 • 31 citations

Cloning of the cDNA encoding human C/EBPγ, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter

1995 • 30 citations

The Human C/EBPδ (CRP3/CELF) Gene: Structure and Chromosomal Localization

1993 • 28 citations

Regulation of Antibody Class Switching to IgE: Characterization of an IL‐4‐Responsive Region in the Immunoglobulin Heavy‐Chain Germline ε Promoter^a

1995 • 27 citations

a1/EBP: a leucine zipper protein that binds CCAAT/enhancer elements in the avian leukosis virus long terminal repeat enhancer

1992 • 26 citations

Identification of a Transcriptional Regulatory Factor for Human Aromatase Cytochrome P450 Gene Expression as Nuclear Factor Interleukin‐6 (NF‐IL6), a Member of the CCAAT/Enhancer‐Binding Protein Family

1995 • 26 citations

C/EBP-related Sites in Addition to a Stat Site Are Necessary for Ciliary Neurotrophic Factor-Leukemia Inhibitory Factor-dependent Transcriptional Activation by the Vasoactive Intestinal Peptide Cytokine Response Element

1995 • 25 citations

The Nuclear Factor NF-IL6 Activates Human Placental Lactogen Gene Expression

1995 • 24 citations

Postnatal liver-specific expression of human insulin-like growth factor-II is highly stimulated by the transcriptional activators liver-enriched activating protein and CCAAT/enhancer binding protein-alpha.

1995 • 23 citations

Characterization of nuclear proteins that bind the EFII enhancer sequence in the Rous sarcoma virus long terminal repeat

1992 • 23 citations

An NFIL-6 Sequence Near the Transcriptional Initiation Site Is Necessary for the Lipopolysaccharide Induction of Murine Interleukin-lβ

1994 • 21 citations

The Human Topoisomerase I Gene Promoter Is Regulated by NF-IL6

1995 • 17 citations

The C/EBP Site in the Feline Immunodeficiency Virus (FIV) Long Terminal Repeat (LTR) Is Necessary for Its Efficient Replication and Is Also Involved in the Inhibition of FIV LTR-Directed Gene Expression by Pseudorabies Virus ICP4

1995 • 17 citations

Interaction of CCAAT/enhancer-binding protein α and β with the rat caeruloplasmin gene promoter

1993 • 14 citations

Functional and defective components of avian endogenous virus long terminal repeat enhancer sequences

1993 • 14 citations

Role of the Transcription Factor C/EBPβ in Expression of a Rat Pregnancy-Specific Glycoprotein Gene

1995 • 14 citations