Mitochondrial glutathione modulates TNF-α-induced endothelial cell dysfunction

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

[70] Determination of glutathione and glutathione disulfide in biological samples

1985 • 2,678 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

1979 • 1,680 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

Traffic Signals on Endothelium for Lymphocyte Recirculation and Leukocyte Emigration

1995 • 1,525 citations

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

1985 • 1,201 citations

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.

1993 • 1,079 citations

Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

1985 • 1,056 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapy

1991 • 906 citations

The Regulation of Hepatic Glutathione

1985 • 615 citations

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.

1995 • 599 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

Detection of catalase in rat heart mitochondria.

1991 • 556 citations

Respiratory chain linked H₂O₂ production in pigeon heart mitochondria

1971 • 544 citations

Origin and turnover of mitochondrial glutathione.

1985 • 492 citations

Functional analysis of the human vascular cell adhesion molecule 1 promoter.

1992 • 442 citations

Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes.

1995 • 339 citations

Mitochondria as a source of reactive oxygen species during reductive stress in rat hepatocytes

1993 • 337 citations

Glutathione redox cycle protects cultured endothelial cells against lysis by extracellularly generated hydrogen peroxide.

1984 • 334 citations

Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression.

1994 • 334 citations

An NFxB-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription

1991 • 245 citations

Use of fluorescent dyes in the determination of adherence of human leucocytes to endothelial cells and the effect of fluorochromes on cellular function

1994 • 241 citations

Molecular mechanisms of tumor necrosis factor‐induced cytotoxicity

1994 • 238 citations

Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice.

1994 • 228 citations

Antioxidant effects of calcium channel blockers against free radical injury in endothelial cells. Correlation of protection with preservation of glutathione levels.

1992 • 225 citations

Mitochondrial damage in muscle occurs after marked depletion of glutathione and is prevented by giving glutathione monoester.

1989 • 206 citations

Antioxidant defense mechanisms of endothelial cells: glutathione redox cycle versus catalase

1986 • 199 citations

Isolation of mitochondria from ascites tumor cells permeabilized with digitonin

1984 • 180 citations

Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-kappa B subunits in endothelial and epithelial cells.

1993 • 170 citations

Fatty acid–mediated effects on the glutathione redox cycle in cultured endothelial cells

1994 • 113 citations

Neutrophil leukocyte emigration induced by endotoxin. Mediator roles of interleukin 1 and tumor necrosis factor alpha 1.

1988 • 112 citations

Tumor necrosis factor-alpha-mediated decrease in glutathione increases the sensitivity of pulmonary vascular endothelial cells to H2O2.

1992 • 107 citations

Role of glutathione redox cycle in TNF-α-mediated endothelial cell dysfunction

1995 • 69 citations

Use of digitonin fractionation to determine mitochondrial transmembrane ion distribution in cells during anoxia

1985 • 64 citations

Multipotent human hematopoietic cell line K562: Lineage-specific constitutive and inducible antigens

1987 • 58 citations

Variable glutathione levels and expression of antioxidant enzymes in human endothelial cells

1993 • 58 citations

Kinetics of virus adsorption to single cells using fluorescent membrane probes and multiparameter flow cytometry

1982 • 13 citations