Glutathione Homeostasis in Human Hepatic Cells: Overexpression of γ-Glutamylcysteine Synthetase Gene in Cell Lines Resistant to Buthionine Sulfoximine, an Inhibitor of Glutathione Synthesis

GLUTATHIONE

1983 • 5,487 citations

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

1979 • 1,680 citations

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.

1992 • 912 citations

ROLE OF REVERSIBLE OXIDATION-REDUCTION OF ENZYME THIOLS-DISULFIDES IN METABOLIC REGULATION

1985 • 840 citations

Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione.

1975 • 729 citations

Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.

1982 • 704 citations

Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair.

1994 • 646 citations

Constitutive and β-Naphthoflavone-induced Expression of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene Is Regulated by a Distal Antioxidant Response Element/TRE Sequence

1997 • 442 citations

Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase.

1993 • 368 citations

Expression of the Multidrug-Resistant Gene in Hepatocarcinogenesis and Regenerating Rat Liver

1987 • 274 citations

Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin C, doxorubicin, and etoposide.

1995 • 240 citations

Amino acid sequence and function of the light subunit of rat kidney gamma-glutamylcysteine synthetase.

1993 • 235 citations

Reversible dissociation of gamma-glutamylcysteine synthetase into two subunits.

1984 • 213 citations

Structure and expression of a human class pi glutathione S-transferase messenger RNA.

1987 • 213 citations

Identification of a Putative Antioxidant Response Element in the 5′-Flanking Region of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene

1995 • 187 citations

Evidence for altered regulation of gamma-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines.

1995 • 176 citations

Tumor Necrosis Factor Increases Hepatocellular Glutathione by Transcriptional Regulation of the Heavy Subunit Chain of γ-Glutamylcysteine Synthetase

1997 • 145 citations

Cloning and nucleotide sequence of a full-length cDNA for human liver γ-glutamylcysteine synthetase

1992 • 118 citations

Cloning and Sequencing of the cDNA for the Light Subunit of Human Liver γ-Glutamylcysteine Synthetase and Relative RNA Levels for Heavy and Light Subunits in Human Normal Tissues

1995 • 118 citations

Mechanisms of Drug Resistance in Neoplastic Cells

1988 • 114 citations

Up-regulation of glutathione synthesis in rat kidney by methyl mercury

1995 • 96 citations

γ-Glutamylcysteine Synthetase Gene Overexpression Results in Increased Activity of the ATP-Dependent Glutathione S-Conjugate Export Pump and Cisplatin Resistance

1995 • 72 citations

Nucleotide sequence of a human gene for glutathione peroxidase

1987 • 62 citations

Differential enhancement of gamma-glutamyl transpeptidase and gamma-glutamylcysteine synthetase by tert-butylhydroquinone in rat lung epithelial L2 cells.

1996 • 62 citations

Identification of heterogeneous and microheterogeneous subunits of glutathione S-transferase in rat liver cytosol

1985 • 46 citations

Markedly Decreased Expression of Glutathione S-Transferase π Gene in Human Cancer Cell Lines Resistant to Buthionine Sulfoximine, an Inhibitor of Cellular Glutathione Synthesis

1995 • 33 citations

Identification ofcis-Acting DNA Elements of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene

1997 • 31 citations

Modulation of detoxification gene expression in human colon HT29 cells by glutathione-S-transferase inhibitors.

1995 • 31 citations

Regulation of epidermal growth factor receptor by activated H-ras and V-myc oncogenes in mouse Balb/3T3 cells: possible roles of AP-1.

1996 • 18 citations

The close association of pi-class glutathione S-transferase with drug sensitivity to alkylating agents and cisplatin in human cancer cells

1997 • 3 citations