POSITIVE VERSUS NEGATIVE SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

‘Actively Acquired Tolerance’ of Foreign Cells

1953 • 3,103 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

The clonal selection theory of acquired immunity

1959 • 2,008 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

Germinal Centers

1994 • 1,680 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

The clonal selection theory of acquired immunity

1959 • 1,576 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1997 • 1,533 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Immunogenetic Consequences of Vascular Anastomoses Between Bovine Twins

1945 • 1,352 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity

1996 • 1,172 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB

1996 • 770 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development

1994 • 733 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Altered Peptide Ligand–Induced Partial T Cell Activation: Molecular Mechanisms and Role in T Cell Biology

1996 • 698 citations

Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

1991 • 694 citations

Genes and Antibodies

1959 • 675 citations

Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.

1994 • 664 citations

Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice

1995 • 663 citations

Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

Positive Selection of Thymocytes

1995 • 604 citations

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1993 • 595 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

1996 • 560 citations

A NEW ANALYSIS OF ALLOGENEIC INTERACTIONS

1975 • 551 citations

Abnormal B lymphocyte delevopment, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule

1995 • 546 citations

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire

1994 • 541 citations

Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

1996 • 535 citations

Recruitment and Activation of PTP1C in Negative Regulation of Antigen Receptor Signaling by FcγRIIB1

1995 • 535 citations

Induction of self-tolerance in mature peripheral B lymphocytes

1989 • 525 citations

Cellular Mechanisms of Immunologic Tolerance

1983 • 521 citations

Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death

1993 • 514 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

1996 • 487 citations

Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice

1991 • 485 citations

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

1995 • 470 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

Regulation of B-Cell Growth and Differentiation by Soluble Factors

1983 • 432 citations

STUDIES ON RABBIT LYMPHOCYTES IN VITRO

1965 • 418 citations

Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor

1996 • 405 citations

The Mechanism of Immunological Paralysis

1968 • 401 citations

Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection

1995 • 394 citations

Different Nuclear Signals Are Activated by the B Cell Receptor during Positive Versus Negative Signaling

1997 • 383 citations

Blocked Ras Activation in Anergic CD4 ⁺ T Cells

1996 • 380 citations

Antigen-induced B-cell death and elimination during germinal-centre immune responses

1995 • 377 citations

Kinetic Differences in Unresponsiveness of Thymus and Bone Marrow Cells

1971 • 374 citations

Effects of Cyclosporine A on T Cell Development and Clonal Deletion

1988 • 354 citations

Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.

1994 • 353 citations

Peripheral deletion of self-reactive B cells

1991 • 353 citations

Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells.

1994 • 340 citations

A Nondeletional Mechanism of Thymic Self Tolerance

1989 • 322 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

Life and Death in Germinal Centers (Redux)

1996 • 315 citations

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells

1995 • 301 citations

NF-κB RelA-deficient Lymphocytes: Normal Development of T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced Proliferative Responses

1997 • 296 citations

Evidence for the clonal abortion theory of B-lymphocyte tolerance.

1975 • 293 citations

Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.

1994 • 293 citations

Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex

1996 • 290 citations

Does T-cell tolerance require a dedicated antigen-presenting cell?

1989 • 288 citations

The site and stage of anti-DNA B-cell deletion

1995 • 283 citations

Abnormal differentiation of thymocytes in mice treated with cyclosporin A

1988 • 281 citations

Involvement of p21ras distinguishes positive and negative selection in thymocytes.

1995 • 278 citations

Immunological Unresponsiveness

1973 • 278 citations

Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate

1995 • 274 citations

Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

1993 • 266 citations

Synergistic interaction between complement receptor type 2 and membrane IgM on B lymphocytes.

1988 • 260 citations

Perturbation of the T Lymphocyte Lineage In Transgenic Mice Expressing a Constitutive Repressor of Nuclear Factor (NF)-κB

1997 • 259 citations

T cell clonal anergy

1997 • 257 citations

Reduced life span of anergic self-reactive B cells in a double-transgenic model.

1994 • 256 citations

Breakdown of self-tolerance in anergic B lymphocytes

1991 • 254 citations

The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help.

1996 • 251 citations

Clonal anergy: Persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen

1980 • 250 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes

1987 • 248 citations

Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45

1996 • 244 citations

SUPPRESSION OF IMMUNOGLOBULIN CLASS SYNTHESIS IN MICE

1972 • 240 citations

Growth control of activated, synchronized murine B cells by the C3d fragment of human complement

1985 • 238 citations

Positive and negative selection invoke distinct signaling pathways.

1996 • 234 citations

A transgenic model of autoimmune hemolytic anemia.

1992 • 232 citations

Differences in susceptibility of mature and immature mouse B lymphocytes to anti-immunoglobulin-induced immunoglobulin suppression in vitro. Possible implications for B-cell tolerance to self.

1975 • 228 citations

Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.

1993 • 221 citations

Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones.

1990 • 218 citations

Split Anergy in a CD8 ⁺ T Cell: Receptor-dependent Cytolysis in the Absence of Interleukin-2 Production

1991 • 199 citations

Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment

1988 • 197 citations

Receptor-mediated inactivation of early B lymphocytes

1975 • 187 citations

The significance of antigen in animal tissues.

1949 • 183 citations

BCR Ligation Induces Receptor Editing in IgM+IgD− Bone Marrow B Cells In Vitro

1997 • 178 citations

Th2 cell clonal anergy as a consequence of partial activation.

1994 • 175 citations

Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP.

1996 • 173 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

The Significance of Antigen in Animal Tissues

1949 • 170 citations

A role for clonal inactivation in T cell tolerance to Mis-1a

1990 • 166 citations

Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides.

1993 • 166 citations

The immunogenicity of soluble haptenated polymers is determined by molecular mass and hapten valence.

1989 • 161 citations

Bound C3 as the second signal for B-cell activation

1973 • 158 citations

Picogram quantities of anti-Ig antibodies coupled to dextran induce B cell proliferation.

1988 • 156 citations

A common factor regulates both Th1- and Th2-specific cytokine gene expression.

1994 • 151 citations

Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme lgM/lgD transgenic mice

1992 • 147 citations

FACTORS INFLUENCING THE PERSISTENCE OF CHORIOMENINGITIS VIRUS IN THE BLOOD OF MICE AFTER CLINICAL RECOVERY

1938 • 141 citations

Immunological Tolerance of Nonliving Antigens

1961 • 136 citations

NONANTIGENICITY AND IMMUNOLOGIC TOLERANCE: THE ROLE OF THE CARRIER IN THE INDUCTION OF TOLERANCE TO THE HAPTEN

1971 • 135 citations

"Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.

1994 • 134 citations

IMMUNOLOGICAL TOLERANCE IN BONE MARROW-DERIVED LYMPHOCYTES

1972 • 134 citations

The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling.

1996 • 132 citations

Tolerance to a Protein Antigen in Adult Mice and the Effect of Nonspecific Factors

1963 • 126 citations

Recruitment and Phosphorylation of SH2-Containing Inositol Phosphatase and Shc to the B-Cell Fcϒ Immunoreceptor Tyrosine-Based Inhibition Motif Peptide Motif

1997 • 122 citations

Cellular Interactions in the Humoral Immune Response

1989 • 121 citations

Cross-linking of IgG receptors inhibits membrane immunoglobulin-stimulated calcium influx in B lymphocytes.

1993 • 117 citations

Studies on the immunogenicity and tolerogenicity of T-independent antigens.

1983 • 117 citations

Molecular mechanisms underlying functional T-cell unresponsiveness

1995 • 115 citations

Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells.

1996 • 115 citations

In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors.

1996 • 113 citations

Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes. Developmentally regulated differences in transmembrane signaling in splenic B cells from adult and neonatal mice.

1991 • 111 citations

In vitro induction of T cell anergy by blocking B7 and early T cell costimulatory molecule ETC-1/B7-2

1994 • 109 citations

THE ABILITY OF BACTERIAL LIPOPOLYSACCHARIDE TO MODULATE THE INDUCTION OF UNRESPONSIVENESS TO A STATE OF IMMUNITY

1973 • 108 citations

Anatomy of autoantibody production: Dominant localization of antibody-producing cells to T cell zones in fas-deficient mice

1995 • 108 citations

T cell responses are governed by avidity and co‐stimulatory thresholds

1996 • 107 citations

Fc receptor off-signal in the B cell involves apoptosis.

1996 • 106 citations

Th1 and Th2 clones differ in their response to a tolerogenic signal.

1990 • 102 citations

In Vitro Tolerance Induction of Bone Marrow Cells: A Marker for B Cell Maturation

1977 • 102 citations

Tolerance induction by clonal deletion of CD4⁺8⁺ thymocytes in vitro does not require dedicated antigen‐presenting cells

1993 • 97 citations

Partial activation of CD8+ T cells by a self-derived peptide

1995 • 95 citations

Negative signaling in B cells causes reduced Ras activity by reducing Shc-Grb2 interactions.

1997 • 94 citations

Cellular and peptide requirements for in vitro clonal deletion of immature thymocytes.

1992 • 90 citations

Regulation of the Interleukin-2 CD28-Responsive Element by NF-ATp and Various NF-κB/Rel Transcription Factors

1997 • 90 citations

Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking

1987 • 89 citations

On the Mechanism of Immunologic Self Recognition

1962 • 89 citations

Role of C3 in in vitro lymphocyte cooperation

1974 • 87 citations

Selective activation of the calcium signaling pathway by altered peptide ligands.

1996 • 83 citations

c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1.

1996 • 81 citations

Studies on the induction of immunologic unresponsiveness. I. Effects of endotoxin and phytochemagglutinin.

1967 • 77 citations

Methylation of an Immediate-Early Inducible Gene as a Mechanism for B Cell Tolerance Induction

1990 • 74 citations

Co-receptors of B lymphocytes

1997 • 73 citations

In Vivo Calcium Elevations in Thymocytes with T Cell Receptors That Are Specific for Self Ligands

1992 • 72 citations

The B lymphocyte calcium response to anti-Ig is diminished by membrane immunoglobulin cross-linkage to the Fc gamma receptor.

1987 • 71 citations

Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells.

1997 • 67 citations

Reduced CD3-mediated protein tyrosine phosphorylation in anergic CD4+ and CD8+ T cells.

1993 • 66 citations

Clonal anergy blocks the response to IL-4, as well as the production of IL-2, in dual-producing T helper cell clones.

1991 • 64 citations

Tolerance as an active process

1980 • 61 citations

Expansion/deletion of mature T cells exposed to endogenous superantigens in vivo.

1994 • 56 citations

Studies on the Induction of Immunologic Unresponsiveness

1967 • 55 citations

Intracellular signals that mediate thymic negative selection

1994 • 54 citations

A reappraisal of "T-independent" antigens. I. Effect of lymphokines on the response of single adult hapten-specific B lymphocytes.

1984 • 52 citations

IMMUNOLOGICAL TOLERANCE IN BONE MARROW-DERIVED LYMPHOCYTES

1974 • 50 citations

Co‐cross‐linking of surface immunoglobulin Fcγ receptors on B lymphocytes uncouples the antigen receptors from their associated G protein

1989 • 47 citations

Peripheral deletion of rheumatoid factor B cells after abortive activation by IgG

1997 • 46 citations

Effect of chronic viral infection on the immune system. I. Comparison of the immune responsiveness of mice chronically infected with LCM virus with that of noninfected mice.

1973 • 44 citations

A CYCLICAL APPEARANCE OF ANTIBODY-PRODUCING CELLS AFTER A SINGLE INJECTION OF SERUM PROTEIN ANTIGEN

1973 • 43 citations

Molecular targets of CD45 in B cell antigen receptor signal transduction.

1997 • 43 citations

Signal Transmission between the Plasma Membrane and Nucleus of T Lymphocytes

1994 • 41 citations

Tolerance Induction by an Apparently Non-immunogenic Molecule

1970 • 34 citations

Membrane and metabolic requirements for tolerance induction of neonatal B cells.

1984 • 34 citations

A functionally compromised intermediate in extrathymic CD8+ T cell deletion

1995 • 34 citations

Altered CD40 ligand induction in tolerant T lymphocytes

1995 • 32 citations

Effect of Chronic Viral Infection on the Immune System

1973 • 26 citations

Immunological Paralysis induced by an Idiotypic Antigen

1970 • 22 citations

Transgenic/knockout mice — tools to study autoimmunity

1995 • 15 citations