A functionally compromised intermediate in extrathymic CD8+ T cell deletion

Antibodies, a laboratory manual

1989 • 12,929 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

A cell-surface molecule involved in organ-specific homing of lymphocytes

1983 • 1,515 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.

1981 • 1,281 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Checkpoints of dueling dimers foil death wishes

1994 • 806 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines

1995 • 686 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis.

1991 • 628 citations

Superantigens and Their Potential Role in Human Disease

1993 • 620 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

Anergic T Cells as Suppressor Cells in Vitro

1994 • 389 citations

Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry.

1986 • 369 citations

Site-Specific Mutagenesis of the Human Interleukin-2 Gene: Structure-Function Analysis of the Cysteine Residues

1984 • 328 citations

The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo

1994 • 291 citations

Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes.

1993 • 286 citations

An endogenous retrovirus mediating deletion of αβ T cells?

1991 • 278 citations

T-cell memory: the connection between function, phenotype and migration pathways

1991 • 271 citations

T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I–E

1989 • 238 citations

Superantigens: Bacterial and Viral Proteins that Manipulate the Immune System

1993 • 236 citations

Mls — a retrovirus exploits the immune system

1991 • 233 citations

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.

1989 • 231 citations

Inhibition of mixed lymphocyte response by a rat monoclonal antibody to a novel murine lymphocyte activation antigen (MALA-2).

1985 • 229 citations

Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry

1994 • 226 citations

Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance.

1995 • 225 citations

Cytotoxic Effects of Antigen- and Mitogen-Induced T Cells on Various Targets

1975 • 224 citations

Specificity and flexibility in thymic selection

1994 • 221 citations

The role of cell division in the induction of clonal anergy

1992 • 203 citations

Requirement for Cotolerogenic Gene Products in the Clonal Deletion of I-E Reactive T Cells

1990 • 193 citations

Immune regulation: a new role for the CD8+ T cell

1994 • 179 citations

A role for clonal inactivation in T cell tolerance to Mis-1a

1990 • 166 citations

Bcl-2 and Bcl-x: regulatory switches for lymphoid death and survival

1994 • 164 citations

Veto Cells

1988 • 150 citations

Fate of H2-activated T lymphocytes in syngeneic hosts

1976 • 147 citations

Major histocompatibility complex independent clonal T cell anergy by direct interaction of Staphylococcus aureus enterotoxin B with the T cell antigen receptor.

1992 • 140 citations

A possible role for bcl-2 in regulating T-cell memory - a ‘balancing act’ between cell death and survival

1993 • 131 citations

Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen

1992 • 128 citations

Self‐Ignorance in the Peripheral T‐Cell Pool

1993 • 124 citations

Peripheral Tolerance as a Multi‐Step Mechanism

1993 • 97 citations

Immune response gene function correlates with the expression of an Ia antigen. I. Preferential association of certain Ae and E alpha chains results in a quantitative deficiency in expression of an Ae:E alpha complex.

1982 • 87 citations

Endogenous superantigen expression is controlled by mouse mammary tumor proviral loci.

1991 • 82 citations

In vivo state of antiviral CTL precursors. Characterization of a cycling cell population containing CTL precursors in immune mice.

1995 • 81 citations

Phylogenetic and Structural Analyses of MMTV LTR ORF Sequences of Exogenous and Endogenous Origins

1993 • 74 citations

Superantigens and retroviral infection: insights from mouse mammary tumor virus

1994 • 74 citations

Identification of the alternatively spliced exons of murine CD45 (T200) required for reactivity with B220 and other T200-restricted antibodies.

1989 • 72 citations

T cell receptor alpha-chain influences reactivity to Mls-1 in V beta 8.1 transgenic mice.

1992 • 69 citations

Reduced CD3-mediated protein tyrosine phosphorylation in anergic CD4+ and CD8+ T cells.

1993 • 66 citations

Identification of a transitional preapoptotic population of thymocytes

1993 • 66 citations

T cell receptor α-chain pairing determines the specificity of residue 262 within the K^b-restricted, ovalbumin_257–264 determinant

1992 • 66 citations

V beta 5+ T cell receptors skew toward OVA+H-2Kb recognition.

1994 • 63 citations

Regulation of CD4 and CD8 expression on mouse T cells. Active removal from the cell surface by two mechanisms.

1993 • 59 citations

Both intrathymic and peripheral selection modulate the differential expression of V beta 5 among CD4+ and CD8+ T cells.

1992 • 54 citations

Lymphokine-activated cell-associated antigen involved in broad-reactive killer cell-mediated cytotoxicity

1985 • 53 citations

Superantigen-driven peripheral deletion of T cells. Apoptosis occurs in cells that have lost the alpha/beta T cell receptor.

1993 • 52 citations

The induction of peripheral tolerance by the chronic activation and deletion of CD4+V beta 5+ cells.

1994 • 45 citations

Expression of the V beta 5.1 gene by murine peripheral T cells is controlled by MHC genes and skewed to the CD8+ subset.

1990 • 40 citations

Semi-automated limit-dilution assay and clonal expansion of all T-cell precursors of cytotoxic lymphocytes

1982 • 38 citations

Skewed T cell receptor V_α repertoire among superantigen reactive murine T cells

1993 • 36 citations

Divergent viral superantigens delete V beta 5+ T lymphocytes.

1992 • 30 citations

Influence of the T cell receptor alpha-chain on T cell reactivity and tolerance to Mls-1 in T cell receptor beta-chain transgenic mice.

1993 • 29 citations

Conformational difference of T cell antigen receptors revealed by monoclonal antibodies to mouse V beta 5 T cell receptor for antigen determinants.

1991 • 29 citations

An approach to the study of structure-function relationships of MHC class I molecules: isolation and serologic characterization of H-2Kb somatic cell variants.

1986 • 27 citations

Peripheral clonal deletion of superantigen‐reactive T cells is enhanced by cortisone

1993 • 24 citations

Aberrant induction of T cell tolerance in B cell suppressed mice.

1993 • 24 citations

Neonatal, moribund and undead T cells: the role of the liver in T cell development

1994 • 23 citations

Development of a mouse mammary tumor virus-negative mouse strain: a new system for the study of mammary carcinogenesis

1982 • 20 citations

Factors influencing the fate of T cells responding to Mls antigens.

1992 • 18 citations

T cell receptor V alpha-V beta combinatorial selection in the expressed T cell repertoire.

1993 • 16 citations

Genetic analysis of the effects of Mtv-2 on the T cell repertoire in the WXG-2 mouse strain

1992 • 15 citations

The Role of CD4 and its Downmodulation in Establishment and Maintenance of HIV‐1 Infection

1994 • 15 citations

Characterization of the Mlsf system. II. Identification of mouse mammary tumor virus proviruses involved in the clonal deletion of self-Mlsf-reactive T cells.

1992 • 14 citations