Recruitment and Phosphorylation of SH2-Containing Inositol Phosphatase and Shc to the B-Cell Fcϒ Immunoreceptor Tyrosine-Based Inhibition Motif Peptide Motif

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Protein modules and signalling networks

1995 • 2,447 citations

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

1987 • 1,627 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

1994 • 886 citations

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB

1996 • 770 citations

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

1996 • 636 citations

Recruitment and Activation of PTP1C in Negative Regulation of Antigen Receptor Signaling by FcγRIIB1

1995 • 535 citations

Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM).

1995 • 463 citations

Cytoplasmic Domain Heterogeneity and Functions of IgG Fc Receptors in B Lymphocytes

1992 • 462 citations

The same tyrosine-based inhibition motif, in the intra-cytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation

1995 • 448 citations

CD22 Is Both a Positive and Negative Regulator of B Lymphocyte Antigen Receptor Signal Transduction: Altered Signaling in CD22-Deficient Mice

1996 • 437 citations

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.

1996 • 429 citations

Fc receptors: Rubor redux

1994 • 361 citations

Cross-linking of B lymphocyte Fc gamma receptors and membrane immunoglobulin inhibits anti-immunoglobulin-induced blastogenesis.

1984 • 292 citations

Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.

1995 • 260 citations

The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein–protein interactions

1996 • 229 citations

Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2

1996 • 223 citations

Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein

1993 • 203 citations

Crosslinking of surface immunoglobulin and Fc receptors on B lymphocytes inhibits stimulation of inositol phospholipid breakdown via the antigen receptors.

1985 • 198 citations

Fc-dependent inhibition of mouse B cell activation by whole anti-mu antibodies.

1983 • 187 citations

Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc.

1994 • 187 citations

The Phosphotyrosine Interaction Domain of SHC Recognizes Tyrosine-phosphorylated NPXY Motif

1995 • 175 citations

Interaction of Shc with Grb2 Regulates Association of Grb2 with mSOS

1995 • 174 citations

Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP.

1996 • 173 citations

Tyrosine-containing motif that transduces cell activation signals also determines internalization and antigen presentation via type III receptors for IgG

1992 • 173 citations

The Src Homology 2 (SH2) Domain of SH2-containing Inositol Phosphatase (SHIP) Is Essential for Tyrosine Phosphorylation of SHIP, Its Association with Shc, and Its Induction of Apoptosis

1997 • 133 citations

Shc Interaction with Src Homology 2 Domain Containing Inositol Phosphatase (SHIP) in VivoRequires the Shc-Phosphotyrosine Binding Domain and Two Specific Phosphotyrosines on SHIP

1997 • 121 citations

Biochemistry of B Lymphocyte Activation

1993 • 120 citations

Cross-linking of IgG receptors inhibits membrane immunoglobulin-stimulated calcium influx in B lymphocytes.

1993 • 117 citations

Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites.

1996 • 104 citations

Negative signaling in B cells causes reduced Ras activity by reducing Shc-Grb2 interactions.

1997 • 94 citations

Tyrosine Phosphorylation of Shc Is Mediated through Lyn and Syk in B Cell Receptor Signaling

1995 • 93 citations

Activation-induced Association of a 145-kDa Tyrosine-phosphorylated Protein with Shc and Syk in B Lymphocytes and Macrophages

1996 • 88 citations

Structure and Function of the B Cell Antigen Receptor

1993 • 86 citations

Negative signaling in B cells: SHIP Grbs Shc

1997 • 81 citations

Negative Signaling via FcγRIIB1 in B Cells Blocks Phospholipase Cγ2 Tyrosine Phosphorylation but Not Syk or Lyn Activation

1996 • 31 citations