Tolerance as an active process

The clonal selection theory of acquired immunity

1959 • 2,008 citations

The clonal selection theory of acquired immunity

1959 • 1,576 citations

Genes and Antibodies

1959 • 675 citations

Membrane and Cytoplasmic Changes in B Lymphocytes Induced by Ligand-Surface Immunoglobulin Interaction

1976 • 383 citations

Molecular determinants of immunogenicity: the immunon model of immune response.

1976 • 366 citations

Evidence for the clonal abortion theory of B-lymphocyte tolerance.

1975 • 293 citations

In vitro tolerance induction of neonatal murine B cells.

1976 • 281 citations

THE MECHANISM OF ANTIGENIC STIMULATION OF PRIMARY AND SECONDARY CLONAL PRECURSOR CELLS

1972 • 272 citations

INDUCTION OF IMMUNITY AND TOLERANCE IN VITRO BY HAPTEN PROTEIN CONJUGATES

1972 • 139 citations

THE USE OF BACTERIAL LIPOPOLYSACCHARIDES TO SHOW THAT TWO SIGNALS ARE REQUIRED FOR THE INDUCTION OF ANTIBODY SYNTHESIS

1973 • 133 citations

IMMUNOLOGICAL TOLERANCE IN VITRO: KINETIC STUDIES AT THE CELLULAR LEVEL

1969 • 115 citations

The Tolerant Cell: Direct Evidence for Receptor Blockade by Tolerogen

1974 • 93 citations

Allogeneic carrier-specific enhancement of hapten-specific secondary B-cell responses.

1976 • 83 citations

Multiple Pathways of B Lymphocyte Tolerance

1979 • 76 citations

EVENTS AFTER THE BINDING OF ANTIGEN TO LYMPHOCYTES

1974 • 64 citations

Antigen-induced aggregation and modulation of receptors on hapten-specific B lymphocytes.

1976 • 63 citations

SPECIFIC ACTIVATION OF THE BONE MARROW-DERIVED LYMPHOCYTE BY ANTIGEN PRESENTED IN A NON-MULTIVALENT FORM

1973 • 46 citations

Maturation of the lymphoid system. I. Induction of tolerance in neonates with a T-dependent antigen that is an obligate immunogen in adults.

1979 • 39 citations

OVERLAP STIMULATION OF PRIMARY AND SECONDARY B CELLS BY CROSS-REACTING DETERMINANTS

1973 • 39 citations

Ontogenic development of B-lymphocyte function and tolerance susceptibility in vivo and in an in vitro organ culture system.

1980 • 31 citations

In vitro model for natural tolerance to self-antigens. Inhibition of the development of surface-immunoglobulin-negative lymphocytes into T-dependent responsive B cells by antigen.

1979 • 29 citations

Maturation of the Lymphoid System

1979 • 25 citations

Regulation of amino acid uptake in lymphocytes stimulated by mitogens

1974 • 24 citations

The Use of Allogeneic T Lymphocytes and Bacterial Lipopolysaccharide to Induce Immune Responses to Monovalent Haptens in Vitro

1974 • 16 citations

Mechanisms of clonal abortion tolerogenesis. IV. Verification of the hypothesis in living mice.

1980 • 15 citations

A Chemical Approach to the Mechanism of B‐Lymphocyte Activation

1978 • 8 citations

A Chemical Approach to the Mechanism of B‐Lymphocyte Activation

1978 • 8 citations