Breakdown of self-tolerance in anergic B lymphocytes

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

The clonal selection theory of acquired immunity

1959 • 2,008 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

The clonal selection theory of acquired immunity

1959 • 1,576 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Induction of self-tolerance in mature peripheral B lymphocytes

1989 • 525 citations

Cellular Mechanisms of Immunologic Tolerance

1983 • 521 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

A Nondeletional Mechanism of Thymic Self Tolerance

1989 • 322 citations

A systemic lupus erythematosus (SLE)‐like disease in mice induced by abnormal T‐B cell cooperation. Preferential formation of autoantibodies characteristic of SLE

1982 • 267 citations

Analysis of Autoimmunity through Experimental Models of Thyroiditis and Allergic Encephalomyelitis

1980 • 253 citations

T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I–E

1989 • 238 citations

A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus.

1986 • 197 citations

Features of systemic lupus erythematosus in mice injected with bacterial lipopolysaccharides: identificantion of circulating DNA and renal localization of DNA-anti-DNA complexes.

1977 • 194 citations

Induction of murine autoimmune disease by chronic polyclonal B cell activation.

1983 • 171 citations

A role for clonal inactivation in T cell tolerance to Mis-1a

1990 • 166 citations

Characterization of self-reactive B cells by polyclonal B-cell activators.

1977 • 125 citations

Intrinsic B-cell hyporesponsiveness accounts for self-tolerance in lysozyme/anti-lysozyme double-transgenic mice.

1990 • 92 citations

Self-tolerance to transgenic γδ T cells by intrathymic inactivation

1990 • 87 citations

Diseases caused by reactions of T lymphocytes to in compatible structures of the major histocompatibility complex. I. Autoimmune hemolytic anemia

1976 • 21 citations