Thymic microenvironments for T cell differentiation and selection

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro

2002 • 1,095 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

TOWARD AN UNDERSTANDING OF NKT CELL BIOLOGY: Progress and Paradoxes

2005 • 1,013 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

Development of a Human Adaptive Immune System in Cord Blood Cell-Transplanted Mice

2004 • 955 citations

CHEMOKINES, SPHINGOSINE-1-PHOSPHATE, AND CELL MIGRATION IN SECONDARY LYMPHOID ORGANS

2004 • 840 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients

2005 • 772 citations

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

2005 • 743 citations

Chemokines in tissue-specific and microenvironment-specific lymphocyte homing

2000 • 643 citations

The Cellular Mechanism of Aire Control of T Cell Tolerance

2005 • 622 citations

A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells

1990 • 611 citations

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

2005 • 540 citations

Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes.

1995 • 517 citations

Central Tolerance to Tissue-specific Antigens Mediated by Direct and Indirect Antigen Presentation

2004 • 474 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Lymphostromal interactions in thymic development and function

2001 • 461 citations

Expression of the Sphingosine 1-Phosphate Receptor, S1P1, on T-cells Controls Thymic Emigration

2004 • 436 citations

Mapping Precursor Movement through the Postnatal Thymus Reveals Specific Microenvironments Supporting Defined Stages of Early Lymphoid Development

2001 • 394 citations

Regulation of NKT cell development by SAP, the protein defective in XLP

2005 • 388 citations

CCR7 Signals Are Essential for Cortex–Medulla Migration of Developing Thymocytes

2004 • 381 citations

Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR

2003 • 361 citations

Self-representation in the thymus: an extended view

2004 • 339 citations

Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product

2005 • 338 citations

Chemokines in the systemic organization of immunity

2003 • 335 citations

A Role for CCR9 in T Lymphocyte Development and Migration

2002 • 321 citations

The generation and fate of thymocytes.

1990 • 309 citations

T-cell development made simple

2004 • 299 citations

Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor γδ+ gut intraepithelial lymphocytes

2001 • 291 citations

Dynamics of Thymocyte-Stromal Cell Interactions Visualized by Two-Photon Microscopy

2002 • 278 citations

Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses

2005 • 278 citations

Dependence of Self-Tolerance on TRAF6-Directed Development of Thymic Stroma

2005 • 272 citations

TCR Signal Strength Influences αβ/γδ Lineage Fate

2005 • 262 citations

Developing a new paradigm for thymus organogenesis

2004 • 242 citations

Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment

2005 • 235 citations

Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1

2005 • 232 citations

Critical Role for CXCR4 Signaling in Progenitor Localization and T Cell Differentiation in the Postnatal Thymus

2003 • 229 citations

Attenuation of γδTCR Signaling Efficiently Diverts Thymocytes to the αβ Lineage

2005 • 227 citations

Role for CCR7 Ligands in the Emigration of Newly Generated T Lymphocytes from the Neonatal Thymus

2002 • 218 citations

Chemokines define distinct microenvironments in the developing thymus

2000 • 218 citations

Thymic T Cell Development and Progenitor Localization Depend on CCR7

2004 • 217 citations

NK1.1+ T Cells in the Liver Arise in the Thymus and Are Selected by Interactions with Class I Molecules on CD4+CD8+ Cells

2000 • 217 citations

The Importation of Hematogenous Precursors by the Thymus Is a Gated Phenomenon in Normal Adult Mice

2001 • 213 citations

Regulatory T cells and autoimmune disease

2005 • 208 citations

NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner

2004 • 207 citations

Lymphotoxin pathway directs thymic Aire expression

2003 • 193 citations

Regulation of Thymus Size by Competition for Stromal Niches among Early T Cell Progenitors

2004 • 192 citations

Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus

2003 • 186 citations

Functional Human T Lymphocyte Development from Cord Blood CD34+ Cells in Nonobese Diabetic/Shi-scid, IL-2 Receptor γ Null Mice

2002 • 174 citations

A Role of CXC Chemokine Ligand 12/Stromal Cell-Derived Factor-1/Pre-B Cell Growth Stimulating Factor and Its Receptor CXCR4 in Fetal and Adult T Cell Development in Vivo

2003 • 173 citations

CCR7 Directs the Migration of Thymocytes into the Thymic Medulla

2004 • 173 citations

Cutting Edge: Signaling Lymphocytic Activation Molecule-Associated Protein Controls NKT Cell Functions

2005 • 171 citations

Directed Migration of Positively Selected Thymocytes Visualized in Real Time

2005 • 169 citations

Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes

2005 • 163 citations

Efficient generation of human T cells from a tissue-engineered thymic organoid

2000 • 152 citations

A potential role for CD69 in thymocyte emigration

2002 • 144 citations

Lymphotoxin-Mediated Regulation of γδ Cell Differentiation by αß T Cell Progenitors

2004 • 143 citations

The role of CCL21 in recruitment of T-precursor cells to fetal thymi

2004 • 137 citations

The inter-relatedness and interdependence of mouse T cell receptor γδ+ and αβ+ cells

2003 • 127 citations

An Alternate Pathway for CD4 T Cell Development: Thymocyte-Expressed MHC Class II Selects a Distinct T Cell Population

2005 • 119 citations

Homing of immature thymocytes to the subcapsular microenvironment within the thymus is not an absolute requirement for T cell development

2004 • 115 citations

Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial differentiation

2002 • 111 citations

Thymocyte-Thymocyte Interaction for Efficient Positive Selection and Maturation of CD4 T Cells

2005 • 110 citations

Thymocyte emigration is mediated by active movement away from stroma-derived factors

2002 • 104 citations

Regulation of an extrathymic T-cell development pathway by oncostatin M

1996 • 102 citations

Dynamic Behavior of T Cells and Thymocytes in Lymphoid Organs as Revealed by Two-Photon Microscopy

2004 • 99 citations

Human skin cells support thymus-independent T cell development

2005 • 95 citations

Systematic mutagenesis of the functional domains of AIRE reveals their role in intracellular targeting

2002 • 94 citations

Controlling the thymic microenvironment

2005 • 92 citations

Thymocyte emigration is mediated by active movement away from stroma-derived factors

2002 • 89 citations

Notch signaling in lymphocyte development and function

2004 • 71 citations

Signaling for NKT cell development

2005 • 69 citations

Up-Regulation of IL-7, Stromal-Derived Factor-1α, Thymus-Expressed Chemokine, and Secondary Lymphoid Tissue Chemokine Gene Expression in the Stromal Cells in Response to Thymocyte Depletion: Implication for Thymus Reconstitution

2005 • 62 citations

Linking signalling pathways, thymic stroma integrity and autoimmunity

2005 • 60 citations

T Cell Development in Mice Expressing CD1d Directed by a Classical MHC Class II Promoter

2003 • 57 citations

T-cell generation by lymph node resident progenitor cells

2005 • 46 citations

An Organized Medullary Epithelial Structure in the Normal Thymus Expresses Molecules of Respiratory Epithelium and Resembles the Epithelial Thymic Rudiment of Nude Mice

2005 • 39 citations

Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells

1999 • 38 citations

Impaired migration of NOD mouse thymocytes: a fibronectin receptor‐related defect

2004 • 35 citations

Murine T cells with invariant gamma delta antigen receptors: origin, repertoire, and specificity.

1991 • 33 citations

Phosphatidylinositol 3-Kinase Regulates Thymic Exit

2005 • 31 citations

Thymocytes Positively Select Thymocytes in Human System

1997 • 27 citations

Deleted Work

1955 • 0 citations