Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

A CENTRAL ROLE FOR CENTRAL TOLERANCE

2006 • 730 citations

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

2005 • 540 citations

Central Tolerance to Tissue-specific Antigens Mediated by Direct and Indirect Antigen Presentation

2004 • 474 citations

RANK signals from CD4+3− inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla

2007 • 463 citations

Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells

2006 • 443 citations

Gene Dosage–limiting Role ofAirein Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity

2004 • 291 citations

Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells

2002 • 290 citations

Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin

2007 • 207 citations

Analysis of thymic stromal cell populations using flow cytometry

2002 • 206 citations

The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells

2006 • 205 citations

Aire-Dependent Alterations in Medullary Thymic Epithelium Indicate a Role for Aire in Thymic Epithelial Differentiation

2007 • 126 citations

Major Histocompatibility Complex Class II Molecules Can Protect from Diabetes by Positively Selecting T Cells with Additional Specificities

1998 • 109 citations

Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells.

1992 • 98 citations

Contrasting models of promiscuous gene expression by thymic epithelium

2005 • 67 citations

The quantitative assessment of MHC II on thymic epithelium: implications in cortical thymocyte development

2006 • 51 citations