Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

1994 • 299 citations

Levels of Peripheral T Cell Tolerance Induced by Different Doses of Tolerogen

1994 • 229 citations

The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens

1989 • 219 citations

Requirement for Cotolerogenic Gene Products in the Clonal Deletion of I-E Reactive T Cells

1990 • 193 citations

Transcription of T cell receptor beta-chain genes is controlled by a downstream regulatory element.

1988 • 185 citations

T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.

1989 • 182 citations

Positive and Negative Selection in Transgenic Mice Expressing a T-Cell Receptor Specific for Influenza Nucleoprotein and Endogenous Superantigen

1993 • 181 citations

Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development.

1997 • 164 citations

Cassette vectors directing expression of T cell receptor genes in transgenic mice

1995 • 159 citations

Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition.

1992 • 159 citations

Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection

1989 • 147 citations

Inefficient positive selection of T cells directed by haematopoietic cells

1992 • 132 citations

Role of chain pairing for the production of functional soluble IA major histocompatibility complex class II molecules.

1996 • 88 citations

Engineered secreted T-cell receptor alpha beta heterodimers.

1991 • 78 citations

T cell receptor α-chain pairing determines the specificity of residue 262 within the K^b-restricted, ovalbumin_257–264 determinant

1992 • 66 citations

Both intrathymic and peripheral selection modulate the differential expression of V beta 5 among CD4+ and CD8+ T cells.

1992 • 54 citations

TCR alpha-chain usage can determine antigen-selected TCR beta-chain repertoire diversity.

1996 • 32 citations