Prevalence and Clinical Associations of 10 Defined Autoantibodies in Autoimmune Polyendocrine Syndrome Type I

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

Clinical Variation of Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy (APECED) in a Series of 68 Patients

1990 • 1,041 citations

The PHD finger: Implications for chromatin-mediated transcriptional regulation

1995 • 857 citations

Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli.

1991 • 547 citations

Autoimmune Polyglandular Syndromes

1980 • 467 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

21-hydroxylase, a major autoantigen in idiopathic Addison's disease

1992 • 403 citations

Autoimmune type 1 diabetes: resolved and unresolved issues

2001 • 306 citations

Identification of protein tyrosine phosphatase-like IA2 (islet cell antigen 512) as the insulin-dependent diabetes-related 37/40K autoantigen and a target of islet-cell antibodies.

1995 • 239 citations

APS-I/APECED: the clinical disease and therapy

2002 • 236 citations

Autoantibodies to the extracellular domain of the calcium sensing receptor in patients with acquired hypoparathyroidism.

1996 • 236 citations

Autoantibodies to steroidogenic enzymes in autoimmune polyglandular syndrome, Addison's disease, and premature ovarian failure.

1996 • 214 citations

Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease.

1993 • 203 citations

Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17α-hydroxylase

1992 • 201 citations

Identification of tryptophan hydroxylase as an intestinal autoantigen

1998 • 190 citations

Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease.

1994 • 182 citations

A vision of cell death: insights into immune privilege

1997 • 177 citations

Localization of the APECED protein in distinct nuclear structures

1999 • 154 citations

The Transcription Factors SOX9 and SOX10 Are Vitiligo Autoantigens in Autoimmune Polyendocrine Syndrome Type I

2001 • 148 citations

High diagnostic accuracy for idiopathic Addison's disease with a sensitive radiobinding assay for autoantibodies against recombinant human 21-hydroxylase.

1995 • 142 citations

Expression of a calcium-sensing receptor in a human medullary thyroid carcinoma cell line and its contribution to calcitonin secretion.

1996 • 133 citations

Autoantibodies against Aromatic<scp>l</scp>-Amino Acid Decarboxylase in Autoimmune Polyendocrine Syndrome Type I¹

1997 • 124 citations

Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with autoimmune polyendocrine syndrome type I.

1996 • 120 citations

Hepatic autoantigens in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy

2001 • 120 citations

Two cytochromes P450 are major hepatocellular autoantigens in autoimmune polyglandular syndrome type 1

1998 • 117 citations

21-hydroxylase autoantibodies in adult patients with endocrine autoimmune diseases are highly specific for Addison's disease

1997 • 113 citations

Gastrointestinal motility disorders and bacterial overgrowth

1995 • 103 citations

Identification of the main gonadal autoantigens in patients with adrenal insufficiency and associated ovarian failure.

1995 • 101 citations

Identification of Tyrosine Hydroxylase as an Autoantigen in Autoimmune Polyendocrine Syndrome Type I

2000 • 101 citations

Cytochrome P450IA2 and aromatic <scp>l</scp>‐amino acid decarboxylase are hepatic autoantigens in autoimmune polyendocrine syndrome type I

1997 • 85 citations

β-Cell Autoantibodies, Human Leukocyte Antigen II Alleles, and Type 1 Diabetes in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy*

2000 • 83 citations

GABA, Glutamic Acid Decarboxylase, and GABA Transaminase Levels in the Myenteric Plexus in the Intestine of Humans and Other Mammals

1983 • 74 citations

Regulated expression of cytochrome P-450scc (cholesterol-side-chain cleavage enzyme) in cultured cell lines detected by antibody against bacterially expressed human protein

1991 • 67 citations

Radioimmunoassay Detects the Frequent Occurrence of Autoantibodies to the Mr 65,000 Isoform of Glutamic Acid Decarboxylase in Japanese Insulin-Dependent Diabetes

1994 • 66 citations

Adrenal and ovarian autoimmunity

1998 • 66 citations

Autoantibodies against Aromatic l-Amino Acid Decarboxylase Identifies a Subgroup of Patients with Addison’s Disease1

2000 • 57 citations

Immunoprecipitation of steroidogenic enzyme autoantigens with autoimmune polyglandular syndrome type I (APS I) sera; further evidence for independent humoral immunity to P450c17 and P450c21

1997 • 56 citations

Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme

1992 • 52 citations

Antibodies to the Tyrosine Phosphatase-like Protein IA-2 are highly associated with IDDM, but not with Autoimmune Endocrine Diseases or Stiff Man Syndrome

1997 • 33 citations

Glutamic acid decarboxylase antibodies, autonomic nerve antibodies and autonomic neuropathy in diabetic patients

1994 • 25 citations