Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease.

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

Molecular Biology of Steroid Hormone Synthesis*

1988 • 1,387 citations

Clinical Variation of Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy (APECED) in a Series of 68 Patients

1990 • 1,041 citations

Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli.

1991 • 547 citations

Autoimmune Polyglandular Syndromes

1980 • 467 citations

Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis.

1990 • 443 citations

21-hydroxylase, a major autoantigen in idiopathic Addison's disease

1992 • 403 citations

Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases

1985 • 364 citations

Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta.

1986 • 359 citations

Determination of functional effects of mutations in the steroid 21-hydroxylase gene (CYP21) using recombinant vaccinia virus.

1990 • 257 citations

Autoantibodies in pathology and cell biology

1991 • 250 citations

Major parietal cell antigen in autoimmune gastritis with pernicious anemia is the acid-producing H+,K+-adenosine triphosphatase of the stomach.

1988 • 227 citations

Molecular cloning and nucleotide sequence of cDNA for mRNA of mitochondrial cytochrome P-450(SCC) of bovine adrenal cortex.

1984 • 208 citations

Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17α-hydroxylase

1992 • 201 citations

STUDIES OF THE ADRENAL ANTIGENS AND ANTIBODIES IN ADDISON'S DISEASE*

1963 • 176 citations

Inherited Susceptibility to Autoimmune Addison's Disease Is Linked to Juman Leukocyte Antigens-DR3 and/or DR4, except when Associated with Type I Autoimmune Poluglandular Syndrome*

1986 • 155 citations

Polyglandular autoimmune syndromes

1984 • 127 citations

A clinical and immunological study of adrenocortical insufficiency (Addison's disease).

1967 • 118 citations

Clinical and Genetic Heterogeneity in Idiopathic Addison's Disease and Hypoparathyroidism

1968 • 110 citations

Evidence for Defective Immunoregulation in the Syndrome of Familial Candidiasis Endocrinopathy

1979 • 109 citations

Properties of an adrenal cytochrome P-450 (P-450scc) for the side chain cleavage of cholesterol

1978 • 104 citations

Gonadal Autoantibodies in Patients with Hypogonadism and/or Addison's Disease*

1981 • 102 citations

CANDIDIASIS: STUDIES PERTAINING TO ITS ASSOCIATION WITH ENDOCRINOPATHIES AND PERNICIOUS ANEMIA

1968 • 98 citations

High-Glucose Stimulation of 64,000-Mr Islet Cell Autoantigen Expression

1989 • 98 citations

Mitochondrial w-Hydroxylation of Cholesterol Side Chain

1974 • 94 citations

The Expression of Autoimmune Polyglandular Disease Type I Appears Associated With Several HLA-A Antigens But Not With HLA-DR*

1988 • 93 citations

ADRENAL ANTIBODIES IN ADDISON'S DISEASE

1962 • 92 citations

Regulated expression of cytochrome P-450scc (cholesterol-side-chain cleavage enzyme) in cultured cell lines detected by antibody against bacterially expressed human protein

1991 • 67 citations

The regulation of adrenocortical function by control of growth and structure

1985 • 66 citations

Autoantibodies and antigens in liver diseases — updated

1989 • 62 citations

Adrenal autoantibodies and Addison disease in insulin-dependent diabetes mellitus

1980 • 59 citations

Immunohistochemical analysis of cytochrome P-450 17α-hydroxylase in pig adrenal cortex, testis and ovary

1989 • 36 citations

For Debate: Enzymes as Targets for Autoantibodies in Human Autoimmune disease: Relevance to Pathogenesis?

1991 • 25 citations

Preparation and Properties of Microsomal Membranes from Isozonal Cells of Beef Adrenal Cortex

1974 • 24 citations

A novel technique for assay of side-chain cleavage of exogenous and endogenous cholesterol in adrenal mitochondrial and submitochondrial preparations

1975 • 13 citations

Hypoparathyroidism and liver disease – evidence for a vitamin D hydroxylation defect A case report

1984 • 8 citations

Adrenal Antibodies in Addison's Disease

1963 • 4 citations