Lipid peroxidation and peroxynitrite in retinal ischemia-reperfusion injury.

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

1979 • 27,693 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Cell death and control of cell survival in the oligodendrocyte lineage

1992 • 1,331 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamide.

1979 • 907 citations

Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury.

1994 • 599 citations

Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes.

1993 • 334 citations

Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines.

1994 • 260 citations

A reinvestigation of the fatty acid content of bovine, rat and frog retinal rod outer segments

1979 • 232 citations

A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress

1994 • 221 citations

Ischemia and reperfusion-induced histologic changes in the rat retina. Demonstration of a free radical-mediated mechanism.

1991 • 213 citations

Path detection and the uncertainty principle

1994 • 159 citations

Biochemistry of reoxygenation injury

1988 • 152 citations

Reactive oxygen species and the neurodegenerative disorders.

1997 • 141 citations

Oxidative protein damage in human diabetic eye: evidence of a retinal participation

1997 • 137 citations

Leukocyte – endothelial cell adhesion induced by ischemia and reperfusion

1993 • 113 citations

Dynamic Changes in the Composition of the AP‐1 Transcription Factor DNA‐binding Activity in Rat Brain Following Kainate‐induced Seizures and Cell Death

1994 • 111 citations

Apoptosis in ocular disease: a molecular overview

1996 • 108 citations

Peroxynitrite and oxidative damage in experimental autoimmune uveitis.

1997 • 103 citations

Neuroprotection by glial cells through adult T cell leukemia-derived factor/human thioredoxin (ADF/TRX)

1994 • 93 citations

Expression of cell cycle-related genes in dying cells in retinal ischemic injury.

1998 • 78 citations

Free Radical-Mediated Effects in Reperfusion Injury: A Histologic Study with Superoxide Dismutase and EGB 761 in Rat Retina

1991 • 69 citations

Ocular ischemia and the effects of allopurinol on functional recovery in the retina of the arterially perfused cat eye.

1993 • 64 citations

How do Ca2+ and 5-aminolevulinic acid-derived oxyradicals promote injury to isolated mitochondria?

1995 • 64 citations

Sodium nitroprusside inhibits N-methyl-D-aspartate-evoked calcium influx via a nitric oxide- and cGMP-independent mechanism.

1992 • 60 citations

Selective c-Jun overexpression is associated with ionizing radiation-induced apoptosis in the developing cerebellum of the rat

1996 • 56 citations

Free Radicals in Rabbit Retina Under Ocular Hyperpressure and Functional Consequences

1997 • 52 citations

Increased cyclin A and decreased cyclin D levels in adenovirus 5 E1A-transformed rodent cell lines.

1993 • 49 citations

Role of nitric oxide in retinal cell death.

1997 • 47 citations

Hydroxyl Radical Generation in the Cat Retina During Reperfusion Following Ischemia

1993 • 47 citations

Protective effect of adult T-cell leukemia-derived factor on retinal ischemia-reperfusion injury in the rat.

1998 • 39 citations

Free radicals and antioxidant supplementation: a review of their roles in age-related macular degeneration.

1993 • 21 citations