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1995 • 448 citations

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes

1997 • 445 citations

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Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages.

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SHIP Modulates Immune Receptor Responses by Regulating Membrane Association of Btk

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Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott–Aldrich syndrome

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The molecular dissection of Fc gamma receptor mediated phagocytosis

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Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.

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Src family protein tyrosine kinases and cellular signal transduction pathways

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Dynamin 2 Is Required for Phagocytosis in Macrophages

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A contractile activity that closes phagosomes in macrophages

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Fc receptor-mediated phagocytosis requires CDC42 and Rac1

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The Rab5 Effector EEA1 Interacts Directly with Syntaxin-6

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Fcγ Receptor–Mediated Phagocytosis in Macrophages Lacking the Src Family Tyrosine Kinases Hck, Fgr, and Lyn

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A Rab11-containing rapidly recycling compartment in macrophages that promotes phagocytosis

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Myosin X is a downstream effector of PI(3)K during phagocytosis

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Intracellular Free Calcium Localization in Neutrophils During Phagocytosis

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A Requirement for ARF6 in Fcγ Receptor-mediated Phagocytosis in Macrophages

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Fcγ Receptor Iib–Deficient Mice Develop Goodpasture's Syndrome upon Immunization with Type IV Collagen

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Control of Actin Dynamics in Cell Motility

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Evidence for a molecular complex consisting of Fyb/SLAP, SLP-76, Nck, VASP and WASP that links the actin cytoskeleton to Fcγ receptor signalling during phagocytosis

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Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells.

1994 • 198 citations

Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis

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Signal transduction by immunoglobulin Fc receptors

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Fc receptor-mediated phagocytosis occurs in macrophages at exceedingly low cytosolic Ca2+ levels.

1988 • 193 citations

Phagosome dynamics and function

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Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG

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Differential Requirement for Classic and Novel PKC Isoforms in Respiratory Burst and Phagocytosis in RAW 264.7 Cells

2000 • 180 citations

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Phosphatidylinositol 3-phosphate is generated in phagosomal membranes

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Rho is Required for the Initiation of Calcium Signaling and Phagocytosis by Fcγ Receptors in Macrophages

1997 • 170 citations

Dichotomy of Ca2+ Signals Triggered by Different Phospholipid Pathways in Antigen Stimulation of Human Mast Cells

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Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.

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Myosin motors: missing structures and hidden springs

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v-SNARE-dependent secretion is required for phagocytosis

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Modular components of phagocytosis

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Human Fc gamma RII, in the absence of other Fc gamma receptors, mediates a phagocytic signal.

1991 • 140 citations

Clustered syk tyrosine kinase domains trigger phagocytosis.

1996 • 140 citations

Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.

1993 • 139 citations

Regulated Expression and Inhibitory Function of FcγRIIb in Human Monocytic Cells

2002 • 135 citations

Membrane trafficking along the phagocytic pathway

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The Role of Dynamin and Its Binding Partners in Coated Pit Invagination and Scission

2001 • 127 citations

Cutting Edge: The Wiskott-Aldrich Syndrome Protein Is Required for Efficient Phagocytosis of Apoptotic Cells

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The glycosyl phosphatidylinositol-linked FcγRIII(PMN) mediates transmembrane signaling events distinct from FcγRII

1990 • 125 citations

Selective in vivo recruitment of the phosphatidylinositol phosphatase SHIP by phosphorylated FcγRIIB during negative regulation of IgE-dependent mouse mast cell activation

1996 • 125 citations

Vav Regulates Activation of Rac but Not Cdc42 during FcγR-mediated Phagocytosis

2002 • 124 citations

Immunoglobulin-mediated phagocytosis by human monocytes requires protein kinase C activation. Evidence for protein kinase C translocation to phagosomes.

1992 • 123 citations

Immunoreceptor tyrosine-based activation motif (ITAM), a unique module linking antigen and Fc receptors to their signaling cascades

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A class VII unconventional myosin is required for phagocytosis

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Rho proteins, PI 3‐kinases, and monocyte/macrophage motility

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Stimulation of macrophage Fc gamma RIIIA activates the receptor-associated protein tyrosine kinase Syk and induces phosphorylation of multiple proteins including p95Vav and p62/GAP-associated protein.

1994 • 117 citations

A WASp-VASP complex regulates actin polymerization at the plasma membrane

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Phagosome-lysosome fusion is a calcium-independent event in macrophages.

1996 • 115 citations

The Fc gamma RI receptor signals through the activation of hck and MAP kinase.

1995 • 114 citations

Differential expression of Fcγ RIIA, Fcγ RIIB and Fcγ RIIC in hematopoietic cells: Analysis of transcripts

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Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides.

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Stimulation of Fc gamma RIIIA results in phospholipase C-gamma 1 tyrosine phosphorylation and p56lck activation.

1992 • 108 citations

Induction of phagocytosis by a protein tyrosine kinase

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ARF6 Is Required for Growth Factor- and Rac-Mediated Membrane Ruffling in Macrophages at a Stage Distal to Rac Membrane Targeting

1999 • 106 citations

Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils

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Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion.

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Syk Tyrosine Kinase Is Required for Immunoreceptor Tyrosine Activation Motif-dependent Actin Assembly

1996 • 100 citations

Src kinase-mediated signaling in leukocytes

2000 • 100 citations

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2000 • 98 citations

Syk Activation Initiates Downstream Signaling Events During Human Polymorphonuclear Leukocyte Phagocytosis

1999 • 98 citations

Structural Features of LIM Kinase That Control Effects on the Actin Cytoskeleton

1999 • 96 citations

Involvement of Group VI Ca2+-independent Phospholipase A2 in Protein Kinase C-dependent Arachidonic Acid Liberation in Zymosan-stimulated Macrophage-like P388D1 Cells

1999 • 96 citations

The Small M_rRas-like GTPase Rap1 and the Phospholipase C Pathway Act to Regulate Phagocytosis inDictyostelium discoideum

1999 • 94 citations

ITIMs and ITAMs

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Contrasting requirements for ubiquitylation during Fc receptor-mediated endocytosis and phagocytosis

2002 • 94 citations

Dynamics of rab5 activation in endocytosis and phagocytosis

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Molecular Basis of the Recruitment of the SH2 Domain-containing Inositol 5-Phosphatases SHIP1 and SHIP2 by FcγRIIB

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Convergence of Fcγ Receptor IIA and Fcγ Receptor IIIB Signaling Pathways in Human Neutrophils

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Actin dynamics in human neutrophils during adhesion and phagocytosis is controlled by changes in intracellular free calcium.

1993 • 88 citations

Role of Src kinases and Syk in Fcγ receptor-mediated phagocytosis and phagosome-lysosome fusion

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Rab7 regulates phagosome maturation in Dictyostelium

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Signal transduction by neutrophil immunoglobulin G Fc receptors. Dissociation of intracytoplasmic calcium concentration rise from inositol 1,4,5-trisphosphate.

1992 • 82 citations

Dictyostelium myosin IK is involved in the maintenance of cortical tension and affects motility and phagocytosis

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Inhibition of Fcγ Receptor-Mediated Phagocytosis by a Nonphagocytic Fcγ Receptor

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Tyrosine phosphorylation and Fcγ receptor‐mediated phagocytosis

1997 • 79 citations

Selective Inhibition of IgG-Mediated Phagocytosis in Gelsolin-Deficient Murine Neutrophils

2000 • 79 citations

Amphiphysin IIm, a Novel Amphiphysin II Isoform, Is Required for Macrophage Phagocytosis

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Activation of Protein Kinase C by Phosphatidylinositol 3,4,5-Trisphosphate

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Membrane dynamics in phagocytosis

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Plasma gelsolin caps and severs actin filaments

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Two mechanisms for IgG Fc-receptor-mediated phagocytosis by human neutrophils.

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Fc-receptor-mediated phagocytosis occurs in macrophages without an increase in average [Ca++]i.

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Fcγ Receptor-mediated Mitogen-activated Protein Kinase Activation in Monocytes Is Independent of Ras

1998 • 69 citations

Arachidonic acid is essential for IgG Fc receptor-mediated phagocytosis by human monocytes.

1991 • 68 citations

Human low-affinity IgG receptor Fc gamma RIIa (CD32) introduced into mouse fibroblasts mediates phagocytosis of sensitized erythrocytes

1992 • 67 citations

FcγRII-mediated Adhesion and Phagocytosis Induce L-Plastin Phosphorylation in Human Neutrophils

1996 • 66 citations

The Requirement of Both Extracellular Regulated Kinase and p38 Mitogen-activated Protein Kinase for Stimulation of Cytosolic Phospholipase A2 Activity by Either FcγRIIA or FcγRIIIB in Human Neutrophils

2000 • 65 citations

A molecular switch changes the signalling pathway used by the FcγRI antibody receptor to mobilise calcium

1998 • 65 citations

The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI.

1994 • 64 citations

Phosphatidylinositol 3-kinase and extracellular signal-regulated kinase are recruited for Fc receptor-mediated phagocytosis during monocyte-to-macrophage differentiation

2002 • 64 citations

The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of FcγRIIB in B cells under negative signaling

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Studies on molecular regulation of phagocytosis and activation of the NADPH oxidase in neutrophils. IgG- and C3b-mediated ingestion and associated respiratory burst independent of phospholipid turnover and Ca2+ transients.

1990 • 63 citations

Protein kinase C activation precedes arachidonic acid release during IgG-mediated phagocytosis.

1995 • 60 citations

Fc gamma RIIIA-mediated signaling involves src-family lck in human natural killer cells.

1993 • 60 citations

Phosphatidylinositol 3-kinase and ERK are required for NF-kappaB activation but not for phagocytosis.

2001 • 60 citations

Correlations among tyrosine phosphorylation of Shc, p72syk, PLC-gamma 1, and [Ca2+]i flux in Fc gamma RIIA signaling.

1994 • 59 citations

Signal Transduction by Human-Restricted FcγRIIa Involves Three Distinct Cytoplasmic Kinase Families Leading to Phagocytosis

2001 • 58 citations

In the absence of other Fc receptors, Fc gamma RIIIA transmits a phagocytic signal that requires the cytoplasmic domain of its gamma subunit.

1993 • 57 citations

Phosphatidylinositol 3-kinase mediates integrin-dependent NF-κB and MAPK activation through separate signaling pathways

2001 • 57 citations

Mitogen-activated protein kinase activation during IgG-dependent phagocytosis in human neutrophils: inhibition by ceramide.

1997 • 56 citations

Bromophenacyl bromide binding to the actin-bundling protein l-plastin inhibits inositol trisphosphate-independent increase in Ca2+ in human neutrophils.

1994 • 56 citations

Expression of the Protein Kinase C Substrate Pleckstrin in Macrophages: Association with Phagosomal Membranes

1999 • 55 citations

Dynamic Ca2+changes in neutrophil phagosomes A source for intracellular Ca2+during phagolysosome formation?

2000 • 55 citations

Requirement for N-Ethylmaleimide-sensitive Factor Activity at Different Stages of Bacterial Invasion and Phagocytosis

2001 • 55 citations

The Ca2+ Dependence of Human Fcγ Receptor-initiated Phagocytosis

1995 • 55 citations

Pag3/Papα/Kiaa0400, a Gtpase-Activating Protein for Adp-Ribosylation Factor (Arf), Regulates Arf6 in Fcγ Receptor–Mediated Phagocytosis of Macrophages

2001 • 55 citations

Phospholipase A2 inhibition results in sequestration of plasma membrane into electronlucent vesicles during IgG-mediated phagocytosis

1997 • 52 citations

Protein Kinase C-α Participates in FcγR-Mediated Phagocytosis in Macrophages

2000 • 52 citations

Complement Receptors, Adhesion, and Phagocytosis

2008 • 52 citations

A role for N‐WASP in invasin‐promoted internalisation

2001 • 52 citations

Phosphatidylinositol 3-kinase and ERK are required for NF-κB activation but not for phagocytosis

2001 • 51 citations

Protein-tyrosine Phosphatase MEG2 Is Expressed by Human Neutrophils

2002 • 50 citations

Immunoglobulin G-mediated phagocytosis activates a calcium-independent, phosphatidylethanolamine-specific phospholipase

1993 • 48 citations

Regulation by CD45 of the tyrosine phosphorylation of high affinity IgE receptor beta- and gamma-chains.

1995 • 44 citations

Control of actin dynamics in cell motility

1999 • 43 citations

Phagocytic and macropinocytic activity in MARCKS-deficient macrophages and fibroblasts

1999 • 43 citations

Differential Mitogen-Activated Protein Kinase Stimulation by Fcγ Receptor IIa and Fcγ Receptor IIIb Determines the Activation Phenotype of Human Neutrophils

2000 • 42 citations

Insufficient Phosphorylation Prevents FcγRIIB from Recruiting the SH2 Domain-containing Protein-tyrosine Phosphatase SHP-1

2001 • 42 citations

Herbimycin A inhibits both dephosphorylation and translocation of cofilin induced by opsonized zymosan in macrophagelike U937 cells

1999 • 42 citations

The Role of Tyrosine Phosphorylation and Ca2+ Accumulation in Fcγ-Receptor-Mediated Phagocytosis of Human Neutrophils1

1995 • 42 citations

Diversity in phagocytic signalling

2001 • 39 citations

Differentiation‐dependent switch in protein kinase C isoenzyme activation by FcγRI, the human high‐affinity receptor for immunoglobulin G

1999 • 39 citations

Mitogen-activated protein kinase is activated during IgG-mediated phagocytosis, but is not required for target ingestion.

1998 • 38 citations

Phospholipase D mediates Fcγ receptor activation of neutrophils and provides specificity between high-valency immune complexes and fMLP signaling pathways

1997 • 37 citations

Protein kinase C and a calcium-independent phospholipase are required for IgG-mediated phagocytosis by Mono-Mac-6 cells

1999 • 36 citations

Phagosomal Proteins of Dictyostelium discoideum

1997 • 35 citations

The cytoplasmic domain of FcγRIIA (CD32) participates in phagolysosome formation

2001 • 34 citations

Fc gamma RIIA-mediated phagocytosis and receptor phosphorylation in cells deficient in the protein tyrosine kinase Src.

1993 • 34 citations

Sphingosine Blocks Human Polymorphonuclear Leukocyte Phagocytosis Through Inhibition of Mitogen-Activated Protein Kinase Activation

1999 • 29 citations

Recent advances in our understanding of Wiskott-Aldrich syndrome

1999 • 25 citations

Indirect Role for COPI in the Completion of Fcγ Receptor-mediated Phagocytosis

2001 • 24 citations

Fcγ Receptors Differ in Their Structural Requirements for Interaction with the Tyrosine Kinase Syk in the Initial Steps of Signaling for Phagocytosis

2001 • 23 citations

FcγRI activation of phospholipase Cγ1 and protein kinase C in dibutyryl cAMP‐differentiated U937 cells is dependent solely on the tyrosine‐kinase activated form of phosphatidylinositol‐3‐kinase

1999 • 23 citations

Role of arachidonate in monocyte/macrophage function

1996 • 2 citations

Deleted Work

1955 • 0 citations