The Requirement of Both Extracellular Regulated Kinase and p38 Mitogen-activated Protein Kinase for Stimulation of Cytosolic Phospholipase A2 Activity by Either FcγRIIA or FcγRIIIB in Human Neutrophils

The MAPK signaling cascade

1995 • 3,300 citations

cPLA2 is phosphorylated and activated by MAP kinase

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Isolation of Lymphocytes, Granulocytes and Macrophages

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Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

F<scp>c</scp>RECEPTOR BIOLOGY

1997 • 1,219 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

Neutrophils, host defense, and inflammation: a double-edged sword

1994 • 807 citations

Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte

1980 • 645 citations

Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors

1997 • 454 citations

The Syk Protein Tyrosine Kinase Is Essential for Fcγ Receptor Signaling in Macrophages and Neutrophils

1998 • 378 citations

CR3 (Mac-1, alpha M beta 2, CD11b/CD18) and Fc gamma RIII cooperate in generation of a neutrophil respiratory burst: requirement for Fc gamma RIII and tyrosine phosphorylation.

1994 • 332 citations

Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.

1997 • 311 citations

Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway

1996 • 310 citations

Activation of a Novel Calcium-dependent Protein-tyrosine Kinase

1996 • 256 citations

Phagocytosis mediated by three distinct Fc gamma receptor classes on human leukocytes.

1990 • 254 citations

Activation of multiple proline-directed kinases by bacterial lipopolysaccharide in murine macrophages.

1996 • 215 citations

Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants.

1994 • 212 citations

Immunoglobulin G–mediated Inflammatory Responses Develop Normally in Complement-deficient Mice

1996 • 209 citations

Essential Requirement of Cytosolic Phospholipase A2for Activation of the Phagocyte NADPH Oxidase

1998 • 199 citations

Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.

1993 • 198 citations

The 40-kDa Fc gamma receptor (FcRII) on human neutrophils is essential for the IgG-induced respiratory burst and IgG-induced phagocytosis.

1989 • 191 citations

Identification of a C3bi-specific membrane complement receptor that is expressed on lymphocytes, monocytes, neutrophils, and erythrocytes

1982 • 176 citations

Tyrosine Phosphorylation of Pyk2 Is Selectively Regulated by Fyn During TCR Signaling

1997 • 165 citations

Vertebrate non‐receptor protein–tyrosine kinase families

1996 • 154 citations

Regulation of Phagocytosis and [Ca ²⁺ ] _i Flux by Distinct Regions of an Fc Receptor

1991 • 150 citations

Formyl peptide receptors are coupled to multiple mitogen-activated protein kinase cascades by distinct signal transduction pathways: role in activation of reduced nicotinamide adenine dinucleotide oxidase.

1997 • 149 citations

G-Protein-coupled Receptors and Fcγ-receptors Mediate Activation of Akt/Protein Kinase B in Human Phagocytes

1997 • 146 citations

Phosphorylation and Activation of Cytosolic Phospholipase A₂ by 38‐kDa Mitogen‐Activated Protein Kinase in Collagen‐Stimulated Human Platelets

1997 • 146 citations

Tyrosine phosphorylation of phospholipase C-gamma 1 induced by cross-linking of the high-affinity or low-affinity Fc receptor for IgG in U937 cells.

1992 • 145 citations

Fc gamma receptor III induces actin polymerization in human neutrophils and primes phagocytosis mediated by Fc gamma receptor II.

1991 • 143 citations

Phosphatidylinositol-linked FcRIII mediates exocytosis of neutrophil granule proteins, but does not mediate initiation of the respiratory burst.

1990 • 142 citations

Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.

1993 • 139 citations

Identification of a New Pyk2 Isoform Implicated in Chemokine and Antigen Receptor Signaling

1998 • 137 citations

Activation of p38 Mitogen-activated Protein Kinase by PYK2/Related Adhesion Focal Tyrosine Kinase-dependent Mechanism

1999 • 133 citations

Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF

1999 • 131 citations

Tumour necrosis factor-α-induced phosphorylation and activation of cytosolic phospholipase A2 are abrogated by an inhibitor of the p38 mitogen-activated protein kinase cascade in human neutrophils

1996 • 126 citations

The glycosyl phosphatidylinositol-linked FcγRIII(PMN) mediates transmembrane signaling events distinct from FcγRII

1990 • 125 citations

The glycosylphosphatidylinositol‐linked Fcγ receptor III represents the dominant receptor structure for immune complex activation of neutrophils

1992 • 110 citations

Fc gamma receptor cross-linking activates p42, p38, and JNK/SAPK mitogen-activated protein kinases in murine macrophages: role for p42MAPK in Fc gamma receptor-stimulated TNF-alpha synthesis.

1997 • 104 citations

Distinct Tyrosine Kinase Activation and Triton X-100 Insolubility upon FcγRII or FcγRIIIB Ligation in Human Polymorphonuclear Leukocytes.

1995 • 98 citations

Stimulation of tyrosine phosphorylation and calcium mobilization by Fc gamma receptor cross-linking. Regulation by the phosphotyrosine phosphatase CD45.

1993 • 92 citations

Fc gamma R-dependent mitogen-activated protein kinase activation in leukocytes: a common signal transduction event necessary for expression of TNF-alpha and early activation genes.

1996 • 91 citations

Cytosolic phospholipase A2 and its mode of activation in human neutrophils by opsonized zymosan: Correlation between 42/44 kDa mitogen-activated protein kinase, cytosolic phospholipase A2 and NADPH oxidase

1997 • 88 citations

Modulation of Fc gamma and complement receptor function by the glycosyl-phosphatidylinositol-anchored form of Fc gamma RIII.

1994 • 85 citations

Phosphorylation of Cytosolic Phospholipase A2 and the Release of Arachidonic Acid in Human Neutrophils

1999 • 80 citations

5-Lipoxygenase Products Modulate the Activity of the 85-kDa Phospholipase A2 in Human Neutrophils

1995 • 75 citations

Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway

1998 • 75 citations

Tyrosine phosphorylation and association of Syk with FcγRII in monocytic THP-1 cells

1995 • 74 citations

Activation of Several MAP Kinases upon Stimulation of Rat Alveolar Macrophages: Role of the NADPH Oxidase

1999 • 67 citations

Signal transduction events and Fc gamma R engagement in human neutrophils stimulated with immune complexes.

1991 • 60 citations

Effect of 1,25-dihydroxyvitamin D3, lipopolysaccharide, or lipoteichoic acid on the expression of NADPH oxidase components in cultured human monocytes.

1991 • 60 citations

Activation of Protein-tyrosine Kinase Pyk2 Is Downstream of Syk in FcεRI Signaling

1997 • 58 citations

Heterotypic FcγR Clusters Evoke a Synergistic Ca2+ Response in Human Neutrophils

1995 • 55 citations

Tyrosine phosphorylation provides an obligatory early signal for Fc gamma RII-mediated endocytosis in the monocytic cell line THP-1.

1994 • 53 citations

Role for a Glycan Phosphoinositol Anchor in Fcγ Receptor Synergy

1997 • 52 citations

Tyrosine phosphorylation-dependent activation of phosphatidylinositide 3-kinase occurs upstream of Ca2+-signalling induced by Fcγ receptor cross-linking in human neutrophils

1997 • 49 citations

A Role for Shc, Grb2, and Raf-1 in FcγRI Signal Relay

1996 • 43 citations

CD28 Ligation Induces Tyrosine Phosphorylation of Pyk2 but Not Fak in Jurkat T Cells

1999 • 34 citations

Functional capacity of Fcγ receptor III (CD16) on human neutrophils

1992 • 32 citations

Selective binding of shc-SH2 domain to tyrosine-phosphorylated zeta but not gamma-chain upon CD16 ligation on human NK cells.

1997 • 29 citations

Signal transduction pathways in normal human monocytes stimulated by cytokines and mediators

1999 • 28 citations

IgM monoclonal antibodies recognizing FcαR but not FcγRIII trigger a respiratory burst in neutrophils although both trigger an increase in intracellular calcium levels and degranulation

1995 • 26 citations

The anti-FcγRIII MAb 3G8 induces neutrophil activation via a cooperative action of FcγRIIIb and FcγRIIa

1997 • 25 citations

Regulation of cytosolic phospholipase A2 by phosphorylation

1998 • 24 citations

Tyrosine phosphorylation induced by cross-linking of Fc γ-receptor type II in human neutrophils

1995 • 16 citations

Human Neutrophil FcαR And FcγRIIa But Not FcγRIIIb Generate Intracellular Calcium Signals Which Trigger The Respiratory Burst

1997 • 9 citations

Calcium Signaling Initiated by CR-1 (CD35) Crosslinking Is Mediated by Phagocyte Fcγ Receptors in cis

1995 • 8 citations