Role of arachidonate in monocyte/macrophage function

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Human cyclooxygenase-2 cDNA.

1992 • 1,493 citations

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

1990 • 940 citations

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

1990 • 777 citations

Advances in prostaglandin, thromboxane, and leukotriene research

1985 • 759 citations

Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2.

1989 • 741 citations

Interfacial Catalysis: the Mechanism of Phospholipase A ₂

1990 • 693 citations

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

1990 • 650 citations

The Annexins and Exocytosis

1992 • 549 citations

Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid.

1992 • 546 citations

Prostaglandins modulate macrophage Ia expression

1982 • 545 citations

Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.

1993 • 521 citations

Metabolism of [14C]arachidonic acid by human platelets

1976 • 453 citations

Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2

1991 • 447 citations

A calcium-dependent mechanism for associating a soluble arachidonoyl-hydrolyzing phospholipase A2 with membrane in the macrophage cell line RAW 264.7.

1990 • 447 citations

Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase).

1988 • 431 citations

Purification of a 110-kilodalton cytosolic phospholipase A2 from the human monocytic cell line U937.

1990 • 428 citations

Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin

1984 • 418 citations

The Ca2(+)-sensitive cytosolic phospholipase A2 is a 100-kDa protein in human monoblast U937 cells.

1991 • 413 citations

Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice.

1990 • 404 citations

Arachidonic Acid and Other Fatty Acids Directly Activate Potassium Channels in Smooth Muscle Cells

1989 • 353 citations

Potassium Channels in Cardiac Cells Activated by Arachidonic Acid and Phospholipids

1989 • 329 citations

Dietary enrichment with the polyunsaturated fatty acid eicosapentaenoic acid prevents proteinuria and prolongs survival in NZB x NZW F1 mice.

1981 • 328 citations

Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. Mechanism-based discrimination between calcium-dependent and -independent phospholipases A2.

1991 • 306 citations

A fish oil diet rich in eicosapentaenoic acid reduces cyclooxygenase metabolites, and suppresses lupus in MRL-lpr mice.

1985 • 304 citations

Leukotriene B: a potential mediator of inflammation

1980 • 303 citations

Interleukin 1 activates phospholipase A2 in rabbit chondrocytes: a possible signal for IL 1 action.

1986 • 259 citations

Evidence for two sources of arachidonic acid for oxidative metabolism by mouse peritoneal macrophages.

1982 • 247 citations

Lipids of alveolar macrophages, polymorphonuclear leukocytes, and their phagocytic vesicles

1972 • 241 citations

Three distinct forms of rat brain protein kinase C: Differential response to unsaturated fatty acids

1987 • 239 citations

Arachidonic acid metabolism by human monocytes. Studies with platelet-depleted cultures.

1983 • 238 citations

Macrophage-mediated tumor cell killing: regulation of expression of cytolytic activity by prostaglandin E.

1981 • 238 citations

Adherence of neutrophils to cultured human microvascular endothelial cells. Stimulation by chemotactic peptides and lipid mediators and dependence upon the Mac-1, LFA-1, p150,95 glycoprotein family.

1989 • 238 citations

Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7

1988 • 236 citations

Purification and characterization of canine myocardial cytosolic phospholipase A2. A calcium-independent phospholipase with absolute f1-2 regiospecificity for diradyl glycerophospholipids.

1990 • 234 citations

Dietary fish oil modulates macrophage fatty acids and decreases arthritis susceptibility in mice.

1985 • 215 citations

Bacterial lipopolysaccharides prime macrophages for enhanced release of arachidonic acid metabolites.

1986 • 211 citations

Fc receptor-mediated phagocytosis occurs in macrophages at exceedingly low cytosolic Ca2+ levels.

1988 • 193 citations

Selective activation of the γ‐subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites

1989 • 188 citations

Modulation of vitronectin receptor binding by membrane lipid composition.

1990 • 180 citations

In vitro fusion of endosomes following receptor-mediated endocytosis.

1988 • 175 citations

Ca(2+)-independent F-actin assembly and disassembly during Fc receptor-mediated phagocytosis in mouse macrophages.

1991 • 175 citations

Integrin modulating factor-1: A lipid that alters the function of leukocyte integrins

1992 • 163 citations

Response of endocytosis to altered fatty acyl composition of macrophage phospholipids.

1977 • 159 citations

The diminished production of arachidonic acid oxygenation products by elicited mouse peritoneal macrophages: possible mechanisms.

1980 • 157 citations

Stimulation of Phospholipase C-γ1 Membrane Association by Epidermal Growth Factor

1990 • 153 citations

Intercompartmental transport in the Golgi complex is a dissociative process: facile transfer of membrane protein between two Golgi populations.

1984 • 149 citations

Growth factor stimulation of phospholipase C-gamma 1 activity. Comparative properties of control and activated enzymes.

1992 • 148 citations

Synthesis of leukotriene C and other arachidonic acid metabolites by mouse pulmonary macrophages.

1982 • 146 citations

Prevention of Glomerulonephritis and Prolonged Survival in New Zealand Black/New Zealand White F1 Hybrid Mice Fed an Essential Fatty Acid-deficient Diet

1981 • 145 citations

Polyunsaturated free fatty acids stimulate an increase in cytosolic Ca2+ by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in T cells through a mechanism independent of phosphoinositide turnover.

1990 • 144 citations

Arachidonic acid metabolites regulate interleukin-1 production

1985 • 137 citations

An 100‐kDa arachidonate‐mobilizing phospholipase A₂ in mouse spleen and the macrophage cell line J774

1991 • 136 citations

Leukotriene A3. A poor substrate but a potent inhibitor of rat and human neutrophil leukotriene A4 hydrolase.

1985 • 131 citations

Paradoxical conservation of cardiac and renal arachidonate content in essential fatty acid deficiency.

1985 • 127 citations

Platelet-activating factor and leukotriene biosynthesis is inhibited in polymorphonuclear leukocytes depleted of arachidonic acid.

1986 • 126 citations

Purification of a phospholipase A2 from human monocytic leukemic U937 cells. Calcium-dependent activation and membrane association.

1990 • 125 citations

Regulation of Prostaglandin H Synthase mRNA Levels and Prostaglandin Biosynthesis by Platelet-derived Growth Factor

1989 • 124 citations

The receptors for ATP and fMetLeuPhe are independently coupled to phospholipases C and A2 via G-protein(s). Relationship between phospholipase C and A2 activation and exocytosis in HL60 cells and human neutrophils

1989 • 123 citations

Calcium-Independent Activation of Hypothalamic Type I Protein Kinase C by Unsaturated Fatty Acids

1988 • 120 citations

[Identification and characterization of two phospholipase A2 activities in resident mouse peritoneal macrophages.]

1981 • 118 citations

Solubilization, purification, and characterization of a membrane-bound phospholipase A2 from the P388D1 macrophage-like cell line.

1988 • 114 citations

Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate.

1992 • 112 citations

Inhibition Studies on the Membrane-associated Phospholipase A2 in vitro and Prostaglandin E2 Production in vivo of the Macrophage-like P388D1 Cell

1989 • 107 citations

The protective effect of dietary fish oil on murine lupus

1985 • 103 citations

Transport of protein between cytoplasmic membranes of fused cells: correspondence to processes reconstituted in a cell-free system.

1984 • 103 citations

Arachidonic acid acts as an intracellular activator of NADPH-oxidase in Fc gamma receptor-mediated superoxide generation in macrophages.

1987 • 98 citations

Histamine-stimulated and GTP-binding proteins-mediated phospholipase A2 activation in rabbit platelets.

1990 • 97 citations

ATP-dependent regulation of rabbit myocardial cytosolic calcium-independent phospholipase A2

1991 • 97 citations

Calcium ionophore enables soluble agonists to stimulate macrophage 5-lipoxygenase.

1985 • 96 citations

Glomerular tumor necrosis factor and interleukin 1 during acute aminonucleoside nephrosis. An immunohistochemical study.

1991 • 95 citations

Cyclooxygenase gene expression is down-regulated by heparin-binding (acidic fibroblast) growth factor-1 in human endothelial cells.

1991 • 83 citations

LYSOSOMAL PHOSPHOLIPASES A1 AND A2 OF NORMAL AND BACILLUS CALMETTE GUERIN-INDUCED ALVEOLAR MACROPHAGES

1973 • 82 citations

Different patterns of arachidonate metabolism in autologous human blood monocytes and alveolar macrophages.

1989 • 80 citations

Mobilization of arachidonic acid between diacyl and ether phospholipids in rabbit alveolar macrophages

1984 • 80 citations

The antiinflammatory effects of essential fatty acid deficiency in experimental glomerulonephritis. The modulation of macrophage migration and eicosanoid metabolism.

1989 • 79 citations

The functional significance of the regulation of macrophage Ia expression by endogenous arachidonate metabolites in vitro.

1986 • 78 citations

Leukotriene A 5 is a substrate and an inhibitor of rat and human neutrophil LTA 4 hydrolase

1985 • 77 citations

Regulation of 5-lipoxygenase and 5-lipoxygenase-activating protein expression in HL-60 cells

1993 • 73 citations

Regulation of intracellular membrane transport

1992 • 73 citations

The epidermal growth factor receptor is coupled to a phospholipase A2-specific pertussis toxin-inhibitable guanine nucleotide-binding regulatory protein in cultured rat inner medullary collecting tubule cells.

1990 • 71 citations

Phosphorylation-dependent regulation of phospholipase A2 by G-proteins and Ca2+ in HL60 granulocytes.

1992 • 70 citations

Fc-receptor-mediated phagocytosis occurs in macrophages without an increase in average [Ca++]i.

1986 • 69 citations

Arachidonic acid is essential for IgG Fc receptor-mediated phagocytosis by human monocytes.

1991 • 68 citations

Evidence of GTP-binding protein regulation of phospholipase A2 activity in isolated human platelet membranes

1989 • 64 citations

Reduced exudation and increased tissue proliferation during chronic inflammation in rats deprived of endogenous prostaglandin precursors

1977 • 64 citations

Essential fatty acid deficiency inhibits the in vivo generation of leukotriene B4 and suppresses levels of resident and elicited leukocytes in acute inflammation.

1988 • 62 citations

Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes.

1990 • 61 citations

Metabolic and functional alterations in macrophages induced by essential fatty acid deficiency.

1987 • 59 citations

Free fatty acid enhancement of cation-induced fusion of liposomes: synergism with synexin and other promoters of vesicle aggregation

1988 • 59 citations

A guanine nucleotide-binding protein participates in IgE receptor-mediated activation of endogenous and reconstituted phospholipase A2 in a permeabilized cell system.

1990 • 57 citations

Thromboxane synthase is preferentially conserved in activated mouse peritoneal macrophages.

1985 • 57 citations

Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors

1990 • 57 citations

Stimulation of arachidonic acid release by guanine nucleotide in saponin-permeabilized neutrophils: Evidence for involvement of GTP-binding protein in phospholipase A2 activation

1988 • 56 citations

Arachidonic acid activates Ca2+ extrusion in macrophages.

1990 • 56 citations

Essential fatty acid deficiency during acute puromycin nephrosis ameliorates late renal injury

1989 • 55 citations

Essential fatty acid deficiency ameliorates acute renal dysfunction in the rat after the administration of the aminonucleoside of puromycin.

1990 • 53 citations

Essential fatty acid deficiency depletes rat glomeruli of resident macrophages and inhibits angiotensin II-induced eicosanoid synthesis.

1987 • 52 citations

Human myocardial cytosolic Ca2+-independent phospholipase A2 is modulated by ATP. Concordant ATP-induced alterations in enzyme kinetics and mechanism-based inhibition

1991 • 52 citations

Glomerular macrophages and the mesangial proliferative response in the experimental nephrotic syndrome.

1992 • 49 citations

Calcium ionophore synergizes with bacterial lipopolysaccharides in activating macrophage arachidonic acid metabolism.

1988 • 48 citations

Immunoglobulin G-mediated phagocytosis activates a calcium-independent, phosphatidylethanolamine-specific phospholipase

1993 • 48 citations

Arachidonate activation of the neutrophil NADPH-oxidase. Synergistic effects of protein phosphatase inhibitors compared with protein kinase activators.

1991 • 45 citations

Studies on enzymes related to diacylglycerol production in activated platelets II. Subcellular distribution, enzymatic properties and positional specificity of diacylglycerol- and monoacylglycerol-lipases

1984 • 44 citations

Essential fatty acid deficiency impairs macrophage spreading and adherence. Role of arachidonate in cell adhesion.

1991 • 42 citations

Reduction of prostaglandin-phase in hind-paw inflammation and partial failure of indomethacin to exert anti-inflammatory effect in rats on essential fatty acid deficient diet

1974 • 41 citations

Monocyte migration explains the changes in macrophage arachidonate metabolism during the immune response.

1986 • 40 citations

Calcium-independent activation of two plant leaf calcium-regulated protein kinases by unsaturated fatty acids

1987 • 38 citations

Manipulation of the acute inflammatory response by dietary polyunsaturated fatty acid modulation.

1990 • 35 citations

Essential fatty acid deficiency prevents multiple low-dose streptozotocin-induced diabetes in CD-1 mice.

1988 • 33 citations

Ca²⁺‐induced reversible translocation of phospholipase A₂ between the cytosol and the membrane fraction of rat liver macrophages

1991 • 33 citations

A selective defect in arachidonic acid release from macrophage membranes in high potassium media.

1984 • 32 citations

Correlation between phospholipase A₂ activity and intra‐Golgi protein transport reconstituted in a cell‐free system

1993 • 31 citations

Phospholipases, Enzymes That Share a Substrate Class

1990 • 30 citations

Phospholipase activation during monocyte adherence and spreading.

1992 • 30 citations

Alveolar macrophages have greater amounts of the enzyme 5-lipoxygenase than do monocytes

1992 • 29 citations

Mechanisms underlying the anti-inflammatory effects of essential fatty acid deficiency in experimental glomerulonephritis. Inhibited release of a monocyte chemoattractant by glomeruli.

1990 • 28 citations

Function of intracellular phospholipase a2 in vectorial transport of apoproteins from er to golgi

1992 • 26 citations

Murine glomerular leukotriene B4 synthesis. Manipulation by (n-6) fatty acid deprivation and cellular origin.

1988 • 25 citations

Phospholipase C and diacylglycerol lipase activities associated with plasma membranes of chromaffin cells isolated from bovine adrenal medulla

1986 • 23 citations

Indomethacin in vivo increases the sensitivity to Listeria infection in mice. A possible role for macrophage thromboxane A2 synthesis.

1987 • 23 citations

Soluble Phospholipase A2 in Human Pathology: Clinical-Laboratory Interface

1990 • 20 citations

Calcium is sufficient but not necessary for activation of sheep platelet cytosolic phospholipase A₂

1991 • 19 citations

[5] Reconstitution of endosome fusion: Identification of factors necessary for fusion competency

1992 • 16 citations

Prostaglandin and thromboxane biosynthesis in isolated platelet-free human monocytes

1989 • 16 citations

Macrophage Phospholipase A2 Activity and Eicosanoid Production: Studies with Phospholipase A2 Inhibitors in P388D1 Cells

1990 • 15 citations

[15] Assays for measuring arachidonic acid release from phospholipids

1991 • 14 citations

Paradoxical exacerbation of leukocyte-mediated glomerulonephritis with cyclooxygenase inhibition

1992 • 13 citations

Essential fatty acid deficiency reduces the inflammatory cell invasion in rabbit hydronephrosis resulting in suppression of the exaggerated eicosanoid production.

1988 • 11 citations

Modification of the arachidonic acid cascade through phospholipase A2 dependent mechanisms.

1990 • 10 citations

Characterization of several phospholipase activities and diacylglycerol/2-monoacylglycerol lipases in rat alveolar macrophages

1991 • 10 citations

Essential fatty acid deficiency inhibits early but not late leukocyte infiltration in rabbit myocardial infarcts

1989 • 8 citations

The reconstitution of intracellular protein transport in cell-free systems.

1990 • 8 citations

Differential turnover of enzymes involved in human monocyte eicosanoid metabolism

1992 • 6 citations

Lung injury caused by cobra venom factor is reduced in rats raised on an essential fatty acid-deficient diet

1989 • 6 citations

Comparative Anatomy of Phospholipase A2 Structures

1990 • 5 citations

FMLP-induced arachidonic acid release, phospholipid metabolism, and calcium mobilization in human monocytes

1988 • 4 citations