Fc receptor-mediated phagocytosis requires CDC42 and Rac1

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

Glucosylation of Rho proteins by Clostridium difficile toxin B

1995 • 1,025 citations

A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages.

1996 • 946 citations

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

1997 • 802 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 725 citations

CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae.

1990 • 605 citations

PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase

1995 • 542 citations

A Critical Role for Syk in Signal Transduction and Phagocytosis Mediated by Fcγ Receptors on Macrophages

1997 • 495 citations

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes

1997 • 445 citations

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

1994 • 439 citations

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

1995 • 437 citations

Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin

1995 • 437 citations

Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages

1997 • 415 citations

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

1992 • 361 citations

Phagocytosis by zippers and triggers

1995 • 314 citations

The molecular dissection of Fc gamma receptor mediated phagocytosis

1995 • 309 citations

The pleckstrin homology domain: An intriguing multifunctional protein module

1996 • 285 citations

Functional and Physical Interactions of Syk Family Kinases with the Vav Proto-Oncogene Product

1996 • 281 citations

Effects of cytochalasin B on polymorphonuclear leucocyte locomotion, phagocytosis and glycolysis

1972 • 258 citations

Tyrosine phosphorylation of the gamma subunit of Fc gamma receptors, p72syk, and paxillin during Fc receptor-mediated phagocytosis in macrophages.

1994 • 244 citations

Membrane and cytoskeletal changes associated with IgE-mediated serotonin release from rat basophilic leukemia cells.

1985 • 224 citations

Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages.

1993 • 201 citations

Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells.

1994 • 198 citations

Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.

1993 • 198 citations

Signal transduction of phagocytosis

1995 • 190 citations

Ca(2+)-independent F-actin assembly and disassembly during Fc receptor-mediated phagocytosis in mouse macrophages.

1991 • 175 citations

Rho is Required for the Initiation of Calcium Signaling and Phagocytosis by Fcγ Receptors in Macrophages

1997 • 170 citations

PSTPIP: A Tyrosine Phosphorylated Cleavage Furrow–associated Protein that Is a Substrate for a PEST Tyrosine Phosphatase

1997 • 169 citations

Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn.

1994 • 148 citations

The Negative Signaling Molecule SH2 Domain-containing Inositol-Polyphosphate 5-Phosphatase (SHIP) Binds to the Tyrosine-phosphorylated β Subunit of the High Affinity IgE Receptor

1997 • 143 citations

Clustered syk tyrosine kinase domains trigger phagocytosis.

1996 • 140 citations

Tyrosine Phosphorylation Regulates the SH3-mediated Binding of the Wiskott-Aldrich Syndrome Protein to PSTPIP, a Cytoskeletal-associated Protein

1998 • 137 citations

Stimulation of macrophage Fc gamma RIIIA activates the receptor-associated protein tyrosine kinase Syk and induces phosphorylation of multiple proteins including p95Vav and p62/GAP-associated protein.

1994 • 117 citations

Syk Tyrosine Kinase Is Required for Immunoreceptor Tyrosine Activation Motif-dependent Actin Assembly

1996 • 100 citations

Src family‐selective tyrosine kinase inhibitor, PP1, inhibits both FcεRI‐ and Thy‐1‐mediated activation of rat basophilic leukemia cells

1997 • 84 citations

Focal Adhesion and Stress Fiber Formation Is Regulated by Tyrosine Phosphatase Activity

1996 • 81 citations

Protein-tyrosine kinase p72syk in Fc gamma RI receptor signaling

1994 • 64 citations

Selective control of membrane ruffling and actin plaque assembly by the Rho GTPases Rac1 and CDC42 in FcεRI-activated rat basophilic leukemia (RBL-2H3) cells

1997 • 63 citations

Monoclonal antibodies to the leukocyte common antigen (CD45) inhibit IgE-mediated histamine release from human basophils.

1991 • 61 citations

Tyrosine-containing activation motif-dependent phagocytosis in mast cells.

1994 • 52 citations

Signal transduction through the conserved motifs of the high affinity IgE receptor FcεRI

1995 • 52 citations

Distinct intracytoplasmic sequences are required for endocytosis and phagocytosis via murine FcγRII in mast cells

1993 • 46 citations

Characterization of a Monoclonal Antibody Specific for the Ras-Related GTP-Binding Protein Rho A

1993 • 35 citations

Tension generation by actomyosin thread from a non-muscle system

1980 • 33 citations

Protein tyrosine phosphatase activity associates with the high affinity IgE receptor and dephosphorylates the receptor subunits, but not Lyn or Syk.

1995 • 30 citations

Identification of a Novel Polyproline Recognition Site in the Cytoskeletal Associated Protein, Proline Serine Threonine Phosphatase Interacting Protein

1998 • 29 citations

Protein-tyrosine kinase activity tightly associated with human type II Fc gamma receptors.

1994 • 26 citations