Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides.

Antisense Oligonucleotides as Therapeutic Agents—Is the Bullet Really Magical?

1993 • 1,306 citations

Fc Receptors

1991 • 1,220 citations

Gene inhibition using antisense oligodeoxynucleotides

1994 • 746 citations

Current concepts in antisense drug design

1993 • 566 citations

Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms.

1991 • 468 citations

Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis

1991 • 449 citations

Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines

1993 • 405 citations

Biology of Human Immunoglobulin G Fc Receptors

1991 • 403 citations

The molecular dissection of Fc gamma receptor mediated phagocytosis

1995 • 309 citations

Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.

1989 • 300 citations

Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor.

1992 • 298 citations

Phagocytosis mediated by three distinct Fc gamma receptor classes on human leukocytes.

1990 • 254 citations

Tyrosine phosphorylation of the gamma subunit of Fc gamma receptors, p72syk, and paxillin during Fc receptor-mediated phagocytosis in macrophages.

1994 • 244 citations

Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells.

1992 • 231 citations

Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.

1993 • 198 citations

Effect of corticosteroids on the human monocyte IgG and complement receptors.

1975 • 182 citations

Activation of Fc gamma RII induces tyrosine phosphorylation of multiple proteins including Fc gamma RII.

1992 • 172 citations

Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII).

1987 • 150 citations

Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex.

1994 • 148 citations

Tyrosine phosphorylation of phospholipase C-gamma 1 induced by cross-linking of the high-affinity or low-affinity Fc receptor for IgG in U937 cells.

1992 • 145 citations

Involvement of p72syk, a protein-tyrosine kinase, in Fc gamma receptor signaling

1993 • 137 citations

Molecular cloning of a human immunoglobulin G Fc receptor.

1988 • 130 citations

Stimulation of macrophage Fc gamma RIIIA activates the receptor-associated protein tyrosine kinase Syk and induces phosphorylation of multiple proteins including p95Vav and p62/GAP-associated protein.

1994 • 117 citations

Differential expression of Fcγ RIIA, Fcγ RIIB and Fcγ RIIC in hematopoietic cells: Analysis of transcripts

1993 • 113 citations

Induction of phagocytosis by a protein tyrosine kinase

1995 • 106 citations

Stimulation of tyrosine phosphorylation and calcium mobilization by Fc gamma receptor cross-linking. Regulation by the phosphotyrosine phosphatase CD45.

1993 • 92 citations

Substitutions and deletions in the cytoplasmic domain of the phagocytic receptor Fc gamma RIIA: effect on receptor tyrosine phosphorylation and phagocytosis [published erratum appears in Blood 1994 Nov 1;84(9):3252]

1994 • 88 citations

Protein tyrosine phosphorylation induced via the IgG receptors Fc gamma Ri and Fc gamma RII in the human monocytic cell line THP-1.

1992 • 75 citations

Tyrosine phosphorylation and association of Syk with FcγRII in monocytic THP-1 cells

1995 • 74 citations

The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI.

1994 • 64 citations

Conserved cytoplasmic tyrosine residues of the gamma subunit are required for a phagocytic signal mediated by Fc gamma RIIIA.

1993 • 58 citations

In the absence of other Fc receptors, Fc gamma RIIIA transmits a phagocytic signal that requires the cytoplasmic domain of its gamma subunit.

1993 • 57 citations

Tyrosine phosphorylation provides an obligatory early signal for Fc gamma RII-mediated endocytosis in the monocytic cell line THP-1.

1994 • 53 citations

Transfection of an Fc gamma receptor cDNA induces T cells to become phagocytic.

1994 • 34 citations

Cloning of the cDNA for the Deleted Syk Kinase Homologous to ZAP-70 from Human Basophilic Leukemia Cell Line (KU812)

1994 • 34 citations

Insertion of cytoplasmic tyrosine sequences into the nonphagocytic receptor Fc gamma RIIB establishes phagocytic function

1994 • 34 citations

Fc gamma RIIA-mediated phagocytosis and receptor phosphorylation in cells deficient in the protein tyrosine kinase Src.

1993 • 34 citations

Receptor specific probes for the study of Fcγ receptor specific function

1992 • 29 citations

Biological advances and clinical applications of Fc receptors for IgG.

1994 • 23 citations

Monocyte Fc gamma receptor recognition of cell-bound and aggregated IgG

1989 • 19 citations

Characterization of Fc gamma receptors on a human erythroleukemia cell line (HEL).

1992 • 7 citations