Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerization and filopodium formation

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Actin-Based Cell Motility and Cell Locomotion

1996 • 1,536 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes.

1989 • 1,268 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

1998 • 933 citations

Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization

1996 • 873 citations

Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association

1998 • 849 citations

Controlling Signal Transduction with Synthetic Ligands

1993 • 815 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

1990 • 699 citations

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.

1996 • 667 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

1998 • 656 citations

Bni1p, a Yeast Formin Linking Cdc42p and the Actin Cytoskeleton During Polarized Morphogenesis

1997 • 654 citations

Actin polymerization is induced by Arp 2/3 protein complex at the surface of Listeria monocytogenes

1997 • 598 citations

Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity.

1990 • 560 citations

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.

1995 • 547 citations

A humanized system for pharmacologic control of gene expression

1996 • 533 citations

How profilin promotes actin filament assembly in the presence of thymosin β4

1993 • 532 citations

The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.

1995 • 479 citations

Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages

1997 • 415 citations

A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family

1997 • 414 citations

Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott–Aldrich syndrome

1996 • 397 citations

Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42.

1995 • 386 citations

WIP, a protein associated with Wiskott–Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells

1997 • 376 citations

The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts.

1992 • 374 citations

Rho- and Rac-dependent Assembly of Focal Adhesion Complexes and Actin Filaments in Permeabilized Fibroblasts: An Essential Role for Ezrin/Radixin/Moesin Proteins

1997 • 303 citations

Interactions of Listeria monocytogenes with mammalian cells during entry and actin-based movement: bacterial factors, cellular ligands and signaling

1998 • 302 citations

Patterns of bud-site selection in the yeast Saccharomyces cerevisiae.

1995 • 298 citations

Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts

1994 • 282 citations

A focal adhesion factor directly linking intracellularly motile Listeria monocytogenes and Listeria ivanovii to the actin-based cytoskeleton of mammalian cells.

1995 • 272 citations

Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase Acts as a Cdc42 Effector in Promoting Cytoskeletal Reorganization

1998 • 269 citations

Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity.

1993 • 256 citations

Fc receptor-mediated phagocytosis requires CDC42 and Rac1

1998 • 254 citations

The essential role of profilin in the assembly of actin for microspike formation

1998 • 237 citations

Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42.

1996 • 229 citations

Corequirement of Specific Phosphoinositides and Small GTP-binding Protein Cdc42 in Inducing Actin Assembly in Xenopus Egg Extracts

1998 • 219 citations

Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins

1997 • 212 citations

Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway

1995 • 209 citations

Identification, purification, and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator-stimulated phosphoprotein).

1995 • 185 citations

Regulation of Actin Polymerization in Cell-free Systems by GTPγS and Cdc42

1997 • 160 citations

Cytokinesis arrest and redistribution of actin-cytoskeleton regulatory components in cells expressing the Rho GTPase CDC42Hs

1996 • 141 citations

Actin-based movement of Listeria monocytogenes: actin assembly results from the local maintenance of uncapped filament barbed ends at the bacterium surface.

1995 • 141 citations

The small GTP-binding proteins, Rac and Rho, regulate cytoskeletal organization and exocytosis in mast cells by parallel pathways.

1996 • 130 citations

Structural and functional similarities between the human cytoskeletal protein zyxin and the ActA protein of Listeria monocytogenes

1997 • 84 citations

Mechanism of Cdc42-induced Actin Polymerization in Neutrophil Extracts

1998 • 71 citations

Genghis Khan (Gek) as a putative effector forDrosophilaCdc42 and regulator of actin polymerization

1997 • 71 citations

Selective control of membrane ruffling and actin plaque assembly by the Rho GTPases Rac1 and CDC42 in FcεRI-activated rat basophilic leukemia (RBL-2H3) cells

1997 • 63 citations

Guanine nucleotide-induced polymerization of actin in electropermeabilized human neutrophils.

1989 • 63 citations

Exploitation of microfilament proteins byListeria monocytogenes: microvillus-like composition of the comet tails and vectorial spreading in polarized epithelial sheets

1994 • 46 citations

Tension generation by actomyosin thread from a non-muscle system

1980 • 33 citations

Actin Polymerization Induced by GTPγS in Permeabilized Neutrophils Is Induced and Maintained by Free Barbed Ends

1995 • 28 citations