The molecular dissection of Fc gamma receptor mediated phagocytosis

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications

1993 • 706 citations

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

1994 • 678 citations

Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells.

1990 • 501 citations

Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis

1991 • 449 citations

Co-association of CD3ζ with a receptor (CD16) for IgG Fc on human natural killer cells

1989 • 412 citations

Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides

1991 • 391 citations

The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal haemoglobinuria

1988 • 387 citations

Differential control of the tyrosine kinases Lyn and Syk by the two signaling chains of the high affinity immunoglobulin E receptor.

1994 • 367 citations

Sequence requirements for induction of cytolysis by the T cell antigenFc receptor ζ chain

1992 • 333 citations

Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain.

1993 • 318 citations

Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.

1989 • 300 citations

Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor.

1992 • 287 citations

A macrophage Fcγ receptor and the mast cell receptor for IgE share an identical subunit

1989 • 268 citations

Phagocytosis mediated by three distinct Fc gamma receptor classes on human leukocytes.

1990 • 254 citations

Tyrosine phosphorylation of the gamma subunit of Fc gamma receptors, p72syk, and paxillin during Fc receptor-mediated phagocytosis in macrophages.

1994 • 244 citations

Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells.

1992 • 231 citations

The B-cell antigen receptor complex

1991 • 213 citations

Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling.

1994 • 212 citations

Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages.

1993 • 201 citations

Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor.

1994 • 200 citations

Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.

1993 • 198 citations

Cocapping of the leukoadhesin molecules complement receptor type 3 and lymphocyte function-associated antigen-1 with Fc gamma receptor III on human neutrophils. Possible role of lectin-like interactions.

1993 • 192 citations

Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain.

1992 • 184 citations

Tyrosine-containing motif that transduces cell activation signals also determines internalization and antigen presentation via type III receptors for IgG

1992 • 173 citations

Activation of Fc gamma RII induces tyrosine phosphorylation of multiple proteins including Fc gamma RII.

1992 • 172 citations

Impaired Function of Macrophage Fcγ Receptors and Bacterial Infection in Alcoholic Cirrhosis

1994 • 165 citations

Regulation of Phagocytosis and [Ca ²⁺ ] _i Flux by Distinct Regions of an Fc Receptor

1991 • 150 citations

Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity.

1994 • 145 citations

Fc gamma receptor III induces actin polymerization in human neutrophils and primes phagocytosis mediated by Fc gamma receptor II.

1991 • 143 citations

Phosphatidylinositol-linked FcRIII mediates exocytosis of neutrophil granule proteins, but does not mediate initiation of the respiratory burst.

1990 • 142 citations

Fc receptor endocytosis is controlled by a cytoplasmic domain determinant that actively prevents coated pit localization.

1992 • 142 citations

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.

1993 • 142 citations

A subunit common to an IgG Fc receptor and the T-cell receptor mediates assembly through different interactions.

1991 • 141 citations

Human Fc gamma RII, in the absence of other Fc gamma receptors, mediates a phagocytic signal.

1991 • 140 citations

Involvement of p72syk, a protein-tyrosine kinase, in Fc gamma receptor signaling

1993 • 137 citations

Impaired Function of Macrophage Fc_γReceptors in End-Stage Renal Disease

1990 • 134 citations

The glycosyl phosphatidylinositol-linked FcγRIII(PMN) mediates transmembrane signaling events distinct from FcγRII

1990 • 125 citations

Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed mutation.

1991 • 121 citations

Stimulation of macrophage Fc gamma RIIIA activates the receptor-associated protein tyrosine kinase Syk and induces phosphorylation of multiple proteins including p95Vav and p62/GAP-associated protein.

1994 • 117 citations

Characterization of the family of dimers associated with Fc receptors (Fc epsilon RI and Fc gamma RIII).

1991 • 114 citations

Differential expression of Fcγ RIIA, Fcγ RIIB and Fcγ RIIC in hematopoietic cells: Analysis of transcripts

1993 • 113 citations

Reconstitution of antibody-dependent phagocytosis in fibroblasts expressing Fc gamma receptor IIIB and the complement receptor type 3.

1994 • 111 citations

Induction of phagocytosis by a protein tyrosine kinase

1995 • 106 citations

Regulation of D‐3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens

1992 • 103 citations

Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction.

1994 • 99 citations

Phagocytic chimeric receptors require both transmembrane and cytoplasmic domains from the mannose receptor.

1992 • 92 citations

Lectin-like inhibition of immune complex receptor-mediated stimulation of neutrophils. Effects on cytosolic calcium release and superoxide production.

1993 • 90 citations

Substitutions and deletions in the cytoplasmic domain of the phagocytic receptor Fc gamma RIIA: effect on receptor tyrosine phosphorylation and phagocytosis [published erratum appears in Blood 1994 Nov 1;84(9):3252]

1994 • 88 citations

Generation of an active protein-tyrosine kinase from lymphocytes by proteolysis.

1988 • 86 citations

Divergent regulation of phosphatidylinositol 3-kinase P85 alpha and P85 beta isoforms upon T cell activation

1993 • 84 citations

Protein tyrosine phosphorylation induced via the IgG receptors Fc gamma Ri and Fc gamma RII in the human monocytic cell line THP-1.

1992 • 75 citations

Association of all three types of Fc gamma R (CD64, CD32, and CD16) with a gamma-chain homodimer in cultured human monocytes.

1993 • 74 citations

Interaction of Fcγ receptor type IIIB with complement receptor type 3 in fibroblast transfectants: Evidence from lateral diffusion and resonance energy transfer studies

1995 • 70 citations

Human low-affinity IgG receptor Fc gamma RIIa (CD32) introduced into mouse fibroblasts mediates phagocytosis of sensitized erythrocytes

1992 • 67 citations

The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI.

1994 • 64 citations

Conserved cytoplasmic tyrosine residues of the gamma subunit are required for a phagocytic signal mediated by Fc gamma RIIIA.

1993 • 58 citations

In the absence of other Fc receptors, Fc gamma RIIIA transmits a phagocytic signal that requires the cytoplasmic domain of its gamma subunit.

1993 • 57 citations

Tyrosine-containing activation motif-dependent phagocytosis in mast cells.

1994 • 52 citations

Surface expression of mutated subunits of the high affinity mast cell receptor for IgE.

1990 • 52 citations

Determinants of the phagocytic signal mediated by the type IIIA Fc gamma receptor, Fc gamma RIIIA: sequence requirements and interaction with protein-tyrosine kinases.

1995 • 47 citations

Transfection of an Fc gamma receptor cDNA induces T cells to become phagocytic.

1994 • 34 citations

Fc gamma RIIA-mediated phagocytosis and receptor phosphorylation in cells deficient in the protein tyrosine kinase Src.

1993 • 34 citations

Insertion of cytoplasmic tyrosine sequences into the nonphagocytic receptor Fc gamma RIIB establishes phagocytic function

1994 • 34 citations

Structural requirements of the cytoplasmic domains of the human macrophage Fcγ receptor IIa and B cell Fcγ receptor IIb2 for the endocytosis of immune complexes

1991 • 31 citations

Receptor specific probes for the study of Fcγ receptor specific function

1992 • 29 citations

Distribution, inducibility and biological function of the cloned and expressed human βFc receptor II

1990 • 28 citations

Prolonged survival of MRL-lpr/lpr mice treated with Tripterygium Wilfordii Hook-F

1992 • 25 citations

Biological advances and clinical applications of Fc receptors for IgG.

1994 • 23 citations

Tyrosine phosphorylation of a gamma-chain homodimer associated with Fc gamma RIII (CD16) in cultured human monocytes.

1993 • 22 citations

Fcγ receptors: Gene structure and receptor function

1992 • 19 citations

Calcium Signalling by the High Affinity Macrophage Fcγ Receptor Requires the Cytosolic Domain

1992 • 14 citations