Lipid Peroxidation and Mechanisms of Toxicity

Free radicals in biology and medicine

1991 • 17,840 citations

Superoxide Dismutase

1969 • 12,578 citations

Selenium: Biochemical Role as a Component of Glutathione Peroxidase

1973 • 7,616 citations

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

GLUTATHIONE

1983 • 5,487 citations

Glutathione peroxidase activity in selenium-deficient rat liver

1976 • 3,413 citations

[44] Glutathione peroxidase

1981 • 2,990 citations

[59] Glutathione reductase

1985 • 2,854 citations

Fenton's reagent revisited

1975 • 2,778 citations

The catalytic decomposition of hydrogen peroxide by iron salts

1934 • 2,483 citations

β-Carotene: an Unusual Type of Lipid Antioxidant

1984 • 2,147 citations

Free Radicals in Biology

1976 • 1,879 citations

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.

1973 • 1,717 citations

Peroxisomes (microbodies and related particles).

1966 • 1,635 citations

The Liver: Biology and Pathobiology.

1983 • 1,628 citations

Free-radical mechanisms in tissue injury

1984 • 1,518 citations

Direct observation of a free radical interaction between vitamin E and vitamin C

1979 • 1,460 citations

Formation of Malonaldehyde from Phospholipid Arachidonate during Microsomal Lipid Peroxidation

1968 • 1,421 citations

Glutathione peroxidase: A selenoenzyme

1973 • 1,358 citations

Free Radicals in Biology and Medicine

1986 • 1,339 citations

Mechanisms of lipid peroxide formation in animal tissues

1966 • 1,291 citations

The Glutathione Status of Cells

1978 • 1,218 citations

Effect of Dietary Selenium on Erythrocyte and Liver Glutathione Peroxidase in the Rat

1974 • 1,205 citations

Superoxide Radical: An Endogenous Toxicant

1983 • 1,176 citations

Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.

1973 • 1,174 citations

Methods in enzymology, vol. 127

1987 • 1,134 citations

Adriamycin: The Role of Lipid Peroxidation in Cardiac Toxicity and Tumor Response

1977 • 1,116 citations

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

1980 • 1,094 citations

Deuterium-isotope Effects in the Autoxidation of Aralkyl Hydrocarbons. Mechanism of the Interaction of PEroxy Radicals¹

1957 • 1,082 citations

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.

1984 • 1,050 citations

The Biochemistry of the Carotenoids

1984 • 1,006 citations

Carbon tetrachloride hepatotoxicity.

1967 • 980 citations

Glutathione: Metabolism and function

1978 • 971 citations

Superoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system.

1975 • 969 citations

The Generation of Hydrogen Peroxide, Superoxide Radical, and Hydroxyl Radical by 6-Hydroxydopamine, Dialuric Acid, and Related Cytotoxic Agents

1974 • 894 citations

Superoxide Dismutase

1973 • 887 citations

Molecular Mechanisms of Oxygen Activation

1974 • 879 citations

[16] Vitamin E analysis methods for animal tissues

1984 • 857 citations

Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site.

1984 • 849 citations

Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay

1983 • 844 citations

Formation of a thiobarbituric‐acid‐reactive substance from deoxyribose in the presence of iron salts

1981 • 830 citations

The thiobarbituric acid reaction and the autoxidations of polyunsaturated fatty acid methyl esters

1962 • 823 citations

LIPID PEROXIDATION, OXYGEN RADICALS, CELL DAMAGE, AND ANTIOXIDANT THERAPY

1984 • 820 citations

Oxidases and Related Redox Systems

1982 • 818 citations

Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides

1982 • 779 citations

HEMOGLOBIN CATABOLISM

1957 • 774 citations

Mechanisms of Photosensitized Oxidation

1968 • 753 citations

Enzymatic Defenses of the Mouse Heart Against Reactive Oxygen Metabolites

1980 • 711 citations

Evidence that Peroxidation of Lysosomal Membranes Is Initiated by Hydroxyl Free Radicals Produced during Flavin Enzyme Activity

1973 • 663 citations

Toxic drug effects associated with oxygen metabolism: Redox cycling and lipid peroxidation

1981 • 650 citations

A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

1978 • 645 citations

Enzymac characterization and lipid composition of rat liver subcellular membranes

1971 • 643 citations

Chemistry of singlet oxygen. VII. Quenching by .beta.-carotene

1968 • 636 citations

Biological Reactive Intermediates

1977 • 597 citations

Functions of glutathione. Biochemical, physiological, toxicological and clinical aspects

1984 • 595 citations

The Biochemistry of the Carotenoids

1980 • 594 citations

Vitamin E as the Biological Lipid Antioxidant

1962 • 581 citations

An enzyme from rat liver catalysing conjugations with glutathione

1961 • 563 citations

Generation of Superoxide Free Radical during the Autoxidation of Thiols

1974 • 558 citations

Paraquat: model for oxidant-initiated toxicity.

1984 • 556 citations

Superoxide- and singlet oxygen-catalyzed lipid peroxidation as a possible mechanism for paraquat (methyl viologen) toxicity

1974 • 540 citations

The stimulatory effects of carbon tetrachloride and other halogenoalkanes on peroxidative reactions in rat liver fractions in vitro. General features of the systems used

1971 • 538 citations

Interaction of ascorbic acid and mitochondrial lipides

1959 • 537 citations

Acute liver necrosis following overdose of paracetamol.

1966 • 525 citations

Mechanisms and Consequences of Lipid Peroxidation in Biological Systems

1985 • 520 citations

Cellular mechanisms of oxygen toxicity.

1968 • 515 citations

ADP-activated lipid peroxidation coupled to the TPNH oxidase system of microsomes

1963 • 512 citations

Liposome oxidation and erythrocyte lysis by enzymically generated superoxide and hydrogen peroxide.

1977 • 509 citations

Swelling and Lysis of Rat Liver Mitochondria Induced by Ferrous Ions

1963 • 491 citations

Autoxidation in Food and Biological Systems

1980 • 487 citations

[40] Spectrophotometric detection of lipid conjugated dienes

1984 • 485 citations

Free Radical Mechanisms of Lipid Damage and Consequences for Cellular Membranes

1976 • 465 citations

Superoxide dismutase and pulmonary oxygen toxicity

1974 • 462 citations

Necrogenic Action of Carbon Tetrachloride in the Rat: A Speculative Mechanism Based on Activation

1966 • 457 citations

Cytosolic factors which affect microsomal lipid peroxidation in lung and liver

1981 • 455 citations

An intracellular GSH-peroxidase with a lipid peroxide substrate

1968 • 450 citations

Ethane Evolution: A New Index of Lipid Peroxidation

1974 • 449 citations

Status of the mitochondrial pool of glutathione in the isolated hepatocyte.

1982 • 440 citations

TREATMENT OF PARACETAMOL (ACETAMINOPHEN) POISONING WITH N-ACETYLCYSTEINE

1977 • 439 citations

The Inhibition of Mitochondrial Peroxidation by Ubiquinone and Ubiquinol

1966 • 433 citations

Relative susceptibility of microsomes from lung, heart, liver, kidney, brain and testes to lipid peroxidation: Correlation with vitamin E content

1980 • 408 citations

CHARACTERIZATION OF THE RED PIGMENT FORMED IN THE 2‐THIOBARBITURIC ACID DETERMINATION OF OXIDATIVE RANCIDITY^a,b

1958 • 403 citations

Hepatic lipid peroxidation in vivo in rats with chronic iron overload.

1983 • 399 citations

Inactivation of ribonuclease and other enzymes by peroxidizing lipids and by malonaldehyde

1969 • 399 citations

Measurement of fluorescent lipid peroxidation products in biological systems and tissues

1973 • 390 citations

The mechanism of NADPH-dependent lipid peroxidation. The propagation of lipid peroxidation.

1979 • 390 citations

Isolation from adrenal cortex of a nonheme iron protein and a flavoprotein functional as a reduced triphosphopyridine nucleotide-cytochrome P-450 reductase

1966 • 379 citations

Purification and properties of human erythrocyte glutathione peroxidase.

1975 • 361 citations

Early onset of lipoperoxidation in rat liver after carbon tetrachloride administration

1968 • 360 citations

Glutathione peroxidase activity of glutathione-S-transferases purified from rat liver

1977 • 360 citations

Lipoperoxidation as a vector in carbon tetrachloride hepatotoxicity.

1966 • 358 citations

Mutagenicity of Malonaldehyde, a Decomposition Product of Peroxidized Polyunsaturated Fatty Acids

1976 • 356 citations

Sensitive fluorometric method for tissue tocopherol analysis

1976 • 352 citations

Functions of Glutathione in Liver and Kidney

1978 • 352 citations

Mechanism of Action of N-Acetylcysteine in the Protection Against the Hepatotoxicity of Acetaminophen in Rats In Vivo

1983 • 351 citations

An enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone‐exposed rats

1972 • 350 citations

Lipid Peroxidation in Mitochondrial Membrane

1980 • 348 citations

The pigments and color of living human skin

1939 • 343 citations

On an Autoxidisable Constituent of the Cell

1921 • 343 citations

Glutathione Peroxidase, V. The kinetic mechanism

1972 • 337 citations

The effect of chronic ethanol ingestion on hepatic lipid peroxide, glutathione, glutathione peroxidase and glutathione transferase in rats

1985 • 337 citations

Microsomal Electron Transport

1973 • 327 citations

Unified mechanism for polyunsaturated fatty acid autoxidation. Competition of peroxy radical hydrogen atom abstraction, .beta.-scission, and cyclization

1981 • 313 citations

Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo

1979 • 298 citations

Evidence for energy-dependent accumulation of paraquat into rat lung

1974 • 294 citations

The isozymes of glutathion transferase

1985 • 293 citations

Liver Necrosis and Lipid Peroxidation in the Rat as the Result of Paraquat and Diquat Administration

1980 • 284 citations

[62] Glutathione transferases from human liver

1985 • 281 citations

[15] High-performance liquid chromatography methods for vitamin E in tissues

1984 • 280 citations

Mechanistic aspects of enhanced lipid peroxidation following glutathione depletion in vivo

1981 • 276 citations

Lipid peroxide formation in microsomes. The role of non-haem iron

1969 • 276 citations

Reviews in biochemical toxicology

1979 • 274 citations

Formation of α-tocopherol radical and recycling of α-tocopherol by ascorbate during peroxidation of phosphatidylcholine liposomesAn electron paramagnetic resonance study

1984 • 270 citations

Comparison of superoxide with other reducing agents in the biological production of hydroxyl radicals

1979 • 268 citations

UNSATURATED LIPIDE OXIDATION CATALYZED BY HEMATIN COMPOUNDS

1955 • 268 citations

Glutathione contents of tissues in the aging mouse

1980 • 268 citations

Evidence for the involvement of iron in the ADP-activatedperoxidation of lipids in microsomes and mitochondria

1964 • 267 citations

Hydroperoxide‐Metabolizing Systems in Rat Liver

1975 • 266 citations

Selenium Distribution and Human Cancer Mortality

1971 • 266 citations

The mechanism of the oxidation of unsaturated fatty acids catalyzed by hematin compounds

1953 • 263 citations

Effect of glutathione peroxidase activity on lipid peroxidation in biological membranes

1976 • 262 citations

Relationship of Selenium to Cancer. I. Inhibitory Effect of Selenium on Carcinogenesis

1970 • 259 citations

Mechanisms of Nitrogen Dioxide Reactions: Initiation of Lipid Peroxidation and the Production of Nitrous Acid

1981 • 256 citations

Inhibition of lipide peroxidation in mitochondria by vitamin E

1959 • 256 citations

A mechanism of paraquat toxicity in mice and rats

1976 • 253 citations

Lipoperoxidation of Lung Lipids in Rats Exposed to Nitrogen Dioxide

1968 • 251 citations

Reduction of carbon tetrachloride in vivo and reduction of carbon tetrachloride and chloroform in vitro by tissues and tissue constituents.

1961 • 249 citations

[38] Detection of malonaldehyde by high-performance liquid chromatography

1984 • 247 citations

Studies of the mechanism of vitamin E action. IV. Lipide peroxidation in the vitamin E-deficient rabbit

1960 • 242 citations

Hepatic Cytosolic Non Selenium-Dependent Glutathione Peroxidase Activity: Its Nature and the Effect of Selenium Deficiency

1978 • 240 citations

SUCCESSFUL TREATMENT OF SEVERE PARACETAMOL OVERDOSAGE WITH CYSTEAMINE

1974 • 237 citations

The glutathione peroxidase activity of glutathione S-transferases

1980 • 235 citations

The influence of phospholipase A2 and glutathione peroxidase on the elimination of membrane lipid peroxides

1983 • 235 citations

The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron

1983 • 234 citations

Cadmium toxicity and lipid peroxidation in isolated rat hepatocytes

1980 • 231 citations

Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine.

1980 • 231 citations

Reactions of the carbon tetrachloride-related peroxy free radical (CCl3O2.) with amino acids : Pulse radiolysis evidence

1978 • 230 citations

Increased chemiluminescence and superoxide production in the liver of chronically ethanol-treated rats

1983 • 224 citations

Reduced Triphosphopyridine Nucleotide Oxidase-catalyzed Alterations of Membrane Phospholipids

1971 • 223 citations

Drug-induced lipid peroxidation in mice—I Modulation by monooxegenase activity, glutathione and selenium status

1981 • 222 citations

Protective role of the glutathione redox cycle against adriamycin-mediated toxicity in isolated hepatocytes

1981 • 221 citations

[32] Chemistry of lipid peroxidation

1984 • 219 citations

Effect of phytyl side chain of vitamin E on its antioxidant activity.

1985 • 218 citations

Alcohol ingestion, liver glutathione and lipoperoxidation: Metabolic interrelations and pathological implications

1982 • 215 citations

Lipid peroxide formation in microsomes. Relationship of hydroxylation to lipid peroxide formation

1969 • 215 citations

ON A NEW AEROBIC METABOLITE WHOSE PRODUCTION BY BRAIN IS INHIBITED BY APOMORPHINE, EMETINE, ERGOTAMINE, EPINEPHRINE, AND MENADIONE

1944 • 215 citations

Release of enzymes from lysosomes by irradiation and the relation of lipid peroxide formation to enzyme release

1966 • 213 citations

Antioxidants and Cancer. IV. Initiating Activity of Malonaldehyde as a Carcinogen

1974 • 213 citations

[34] Chemical methods for the detection of lipid hydroperoxides

1984 • 210 citations

Mechanism of adriamycin cardiotoxicity: Evidence for oxidative stress

1981 • 210 citations

CYSTEAMINE, METHIONINE, AND PENICILLAMINE IN THE TREATMENT OF PARACETAMOL POISONING

1976 • 206 citations

The measurement of lipid peroxidation in isolated hepatocytes

1982 • 206 citations

Effect of dietary vitamin E on expiration of pentane and ethane by the rat

1977 • 206 citations

The role of superoxide and singlet oxygen in lipid peroxidation promoted by xanthine oxidase

1973 • 206 citations

Comparison of the biochemical alterations elicited in livers from rats treated with carbon tetrachloride, chloroform, 1,1,2-trichloroethaneand 1,1,1-trichloroethane

1969 • 205 citations

A Correlation between Glutathione Levels and Cellular Damage in Isolated Hepatocytes

1977 • 204 citations

Glutathione-dependent protection by rat liver microsomal protein against lipid peroxidation

1983 • 202 citations

Evidence for superoxide-dependent reduction of Fe3+ and its role in enzyme-generated hydroxyl radical formation

1976 • 201 citations

NADH- and NADPH-dependent lipid peroxidation in bovine heart submitochondrial particles. Dependence on the rate of electron flow in the respiratory chain and an antioxidant role of ubiquinol

1980 • 200 citations

Free-Radical Intermediates in the Metabolism of Toxic Chemicals

1982 • 197 citations

Reduction of linolenic acid hydroperoxide by a glutathione peroxidase

1969 • 197 citations

[59] Glutathione disulfide (GSSG) efflux from cells and tissues

1984 • 197 citations

Response of Glutathione Peroxidase to Dietary Selenium in Rats

1974 • 196 citations

The accumulation of malonyldialdehyde, a product of fatty acid peroxidation, can disturb aminophospholipid organization in the membrane bilayer of human erythrocytes.

1984 • 196 citations

Paraquat toxicity: proposed mechanism of action involving lipid peroxidation.

1976 • 196 citations

Calcium uptake of a rat liver microsomal subcellular fraction in response to in vivo administration of carbon tetrachloride.

1976 • 192 citations

Oxygen and oxy-radicals in chemistry and biology

1981 • 191 citations

Inhibition of the TPNH-linked lipid peroxidation of liver microsomes by drugs undergoing oxidative demethylation

1964 • 191 citations

Effect of Superoxide Generation and Dismutation on Hydroxylation Reactions Catalyzed by Liver Microsomal Cytochrome P-450

1971 • 189 citations

Paraquat

1976 • 187 citations

SELENIUM AND GLUTATHIONE PEROXIDASE IN DEVELOPING RAT BRAIN¹

1976 • 183 citations

Glutathione dependent control of protein disulfide-sulfhydryl content by subcellular fractions of hepatic tissue

1977 • 182 citations

Excessive accumulation of autofluorescent lipofuscin in the liver during hepatocarcinogenesis by methyl clofenapate and other hypolipidemic peroxisome proliferators.

1982 • 182 citations

Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen

1982 • 180 citations

NADPH-dependent lipid peroxidation catalyzed by purified NADPH-cytochrome c reductase from rat liver microsomes

1972 • 179 citations

Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by adriamycin and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)

1983 • 177 citations

Inhibition of ATP-dependent microsomal Ca2+ sequestration during oxidative stress and its prevention by glutathione.

1983 • 176 citations

Free radicals and singlet oxygen scavengers: Reaction of a peroxy-radical with β-carotene, diphenyl furan and 1,4-diazobicyclo(2,2,2)-octane

1981 • 175 citations

Lipid Peroxidation in Vivo during Vitamin E and Selenium Deficiency in the Rat as Monitored by Ethane Evolution

1977 • 175 citations

Protection against lipid peroxidation by a microsomal glutathione‐dependent labile factor

1983 • 174 citations

Interaction of DNA with Bifunctional Aldehydes

1968 • 171 citations

Non‐reactivity of the selenoenzyme glutathione peroxidase with enzymatically hydroperoxidized phospholipids

1983 • 171 citations

Production of active oxygen species (1O2 and O2⨪) by psoralens and ultraviolet radiation (320–400 nm)

1984 • 170 citations

Glutathione Depletion in Isolated Hepatocytes: Its Relation to Lipid Peroxidation and Cell Damage

1979 • 168 citations

Activation of microsomal glutathione S-transferase activity by sulfhydryl reagents

1979 • 168 citations

Singlet oxygen production associated with enzyme-catalyzed lipid peroxidation in liver microsomes

1975 • 167 citations

Spin-trapping studies on the free-radical products formed by metabolic activation of carbon tetrachloride in rat liver microsomal fractions isolated hepatocytes and in vivo in the rat

1982 • 167 citations

Peroxide removal by selenium-dependent and selenium-independent glutathione peroxidases in hemoglobin-free perfused rat liver.

1978 • 167 citations

Superoxide dismutase is a prophylactic against alloxan diabetes

1981 • 166 citations

Stimulation by adriamycin of rat heart and liver microsomal NADPH-dependent lipid peroxidation

1981 • 166 citations

Confirmation of assignment of the trichloromethyl radical spin adduct detected by spin trapping during 13C-carbon tetrachloride metabolism , , , ,

1980 • 165 citations

Reduction of paraquat toxicity by superoxide dismutase

1974 • 165 citations

Differential effect of lipid peroxidation on membrane fluidity as determined by electron spin resonance probes

1983 • 165 citations

Low Level Chemiluminescence of Liver Microsomal Fractions Initiated by tert‐Butyl Hydroperoxide

1982 • 165 citations

Ozone and Lipid Peroxidation

1969 • 164 citations

Effect of ethanol on glutathione concentration in isolated hepatocytes

1980 • 164 citations

The Nature and Distribution of Enzymes Catalyzing the Conjugation of Glutathione with Foreign Compounds

1974 • 163 citations

Studies on the mechanism of the lung toxicity of paraquat: Comparison of tissue distribution and some biochemical parameters in rats and rabbits

1974 • 163 citations

THE ROLE OF SUPEROXIDE AND SINGLET OXYGEN IN LIPID PEROXIDATION

1978 • 163 citations

Peroxidation of lipids in tissue homogenates as related to vitamin E

1960 • 162 citations

Inhibition by polyamines of lipid peroxide formation in rat liver microsomes

1979 • 162 citations

Studies on Adrenal Steroid Hydroxylases

1973 • 161 citations

The effect of diet on the toxicity of paracetamol and the safety of paracetamol-methionine mixtures

1975 • 161 citations

Evidence for carbon tetrachloride- and ethanol-induced lipid peroxidation in Vivo demonstrated by ethane production in mice and rats

1977 • 160 citations

Liver glutathione depletion induced by bromobenzene, iodobenzene, and diethylmaleate poisoning and its relation to lipid peroxidation and necrosis.

1985 • 159 citations

An investigation into the role of hydroxyl radical in xanthine oxidase-dependent lipid peroxidation

1982 • 159 citations

Maintenance of glutathione content is isolated hepatocyctes

1978 • 158 citations

Isolation of chick renal mitochondrial ferredoxin active in the 25-hydroxyvitamin D3-1alpha-hydroxylase system.

1976 • 156 citations

Lipid Peroxidation of Rat‐Liver Microsomes

1973 • 156 citations

Acute toxicity of cephaloridine, an antibiotic derived from cephalosporin C

1966 • 154 citations

Polynuclear complexes of iron and their biological implications

2008 • 153 citations

Free malonaldehyde determination in tissues by high-performance liquid chromatography

1984 • 153 citations

Hydroxyl radical production involved in lipid peroxidation of rat liver microsomes

1977 • 151 citations

[41] Fluorescent damage products of lipid peroxidation

1984 • 150 citations

Cytotoxic aldehydes originating from the peroxidation of liver microsomal lipids

1984 • 150 citations

Hydroxyl radical production and DNA damage induced by anthracycline‐iron complex

1984 • 149 citations

Formation of malonaldehyde from lipid oxidation products

1983 • 149 citations

Oxygen species in paraquat toxicity: the crypto‐OH radical

1981 • 149 citations

Protection Against Carbon Tetrachloride-Induced Lipid Peroxidation in the Rat by Dietary Vitamin E, Selenium, and Methionine as Measured by Ethane Evolution

1977 • 148 citations

Cytochrome P-450-dependent oxygenation of arachidonic acid to hydroxyicosatetraenoic acids.

1982 • 147 citations

Role of alcohol dehydrogenase activity and the acetaldehyde in ethanol- induced ethane and pentane production by isolated perfused rat liver

1982 • 146 citations

Glutathione peroxidase and the destruction of hydrogen peroxide in animal tissues

1960 • 145 citations

Regulatory role of glutathione and soluble sulfhydryl groups in the toxicity of adriamycin.

1980 • 145 citations

Microsomal lipid peroxidation causes an increase in the order of the membrane lipid domain

1982 • 145 citations

Silymarin protection against hepatic lipid peroxidation induced by acute ethanol intoxication in the rat

1985 • 145 citations

Reduced Triphosphopyridine Nucleotide Oxidase-catalyzed Alterations of Membrane Phospholipids

1968 • 144 citations

Biochemical mechanisms of liver injury

1970 • 144 citations

Evidence for the occurrence of selenium-independent glutathione peroxidase activity in rat liver microsomes

1981 • 139 citations

Cellular toxicity and lipid peroxidation in response to mercury

1982 • 136 citations

The role of superoxide and hydroxyl radicals in phospholipid peroxidation catalysed by iron salts

1982 • 136 citations

Toxicity of paraquat to rats and its effect on rat lungs

1970 • 136 citations

The mechanism of liver microsomal lipid peroxidation

1975 • 136 citations

Mechanisms of cell injury in the killing of cultured hepatocytes by bromobenzene.

1982 • 135 citations

Peroxisome proliferation and lipid peroxidation in rat liver.

1986 • 132 citations

Comparison of the mutagenicities of malondialdehyde and the side products formed during its chemical synthesis.

1980 • 132 citations

The inhibitory effect of reduced glutathione on the lipid peroxidation of the microsomal fraction and mitochondria

1968 • 129 citations

Positive evidence of acceleration of lipoperoxidation in rat liver by carbon tetrachloride: experiments

1965 • 129 citations

Dose-rate and Oxygen Effects in Models of Lipid Membranes: Linoleic Acid

1977 • 128 citations

Inhibition of microsomal lipid peroxidation by glutathione and glutathione transferases B and AA. Role of endogenous phospholipase A2

1984 • 128 citations

The biochemistry of the eye

1934 • 127 citations

Mechanism of action of paracetamol protective agents in mice in vivo

1984 • 127 citations

Effect of acute ethanol intoxication on the content of reduced glutathione of the liver in relation to its lipoperoxidative capacity in the rat

1980 • 126 citations

Spin trapping and its application in the study of lipid peroxidation and free radical production with liver microsomes

1977 • 126 citations

Direct demonstration that ferrous ion complexes of di- and triphosphate nucleotides catalyze hydroxyl free radical formation from hydrogen peroxide

1983 • 125 citations

Mechanism of phospholipid peroxidation induced by ferric ion-ADP-adriamycin-co-ordination complex

1982 • 125 citations

Destruction of liver microsomal calcium pump activity by carbon tetrachloride and bromotrichloromethane

1981 • 123 citations

Drug-induced lipid peroxidation in mice—II

1982 • 122 citations

The Role of Free Radicals in the Toxicity of Air Pollutants (Nitrogen Oxides and Ozone)

1976 • 121 citations

No chemical evidence of hepatic lipid peroxidation in acute ethanol toxicity

1968 • 121 citations

Quantitative determination of organic solvent soluble lipofuscin pigments in tissues

1976 • 120 citations

Lipid peroxidation: A possible mechanism of cephaloridine-induced nephrotoxicity

1983 • 119 citations

Pathology of oxygen

1982 • 118 citations

Lipid peroxidation of rat liver microsomes

1980 • 118 citations

Increase in hepatic mixed disulphide and glutathione disulphide levels elicited by paraquat

1982 • 118 citations

Lipid Peroxidation in Isolated Hepatocytes

1975 • 118 citations

Lipid oxidation in biological membranes

1970 • 117 citations

[64] Glutathione transferase from rat testis

1985 • 117 citations

Acetaminophen and its toxicity

1983 • 117 citations

INTERACTIONS OF VITAMIN E AND SELENIUM WITH MERCURY AND SILVER

1980 • 117 citations

The distribution of glutathione in the rat liver lobule

1979 • 115 citations

In vitro stimulation by paraquat of reactive oxygen-mediated lipid peroxidation in rat lung microsomes

1981 • 115 citations

Effect of Ozone on Lipid Peroxidation in the Red Blood Cell.

1967 • 114 citations

SUPEROXIDE DISMUTASE

1974 • 114 citations

Carbon tetrachloride hepatotoxicity:status quo and future prospects

1983 • 113 citations

Microsomal metabolism of hydroxyl radical scavenging agents: Relationship to the microsomal oxidation of alcohols

1980 • 113 citations

Influence of vitamin E and selenium on glutathione-dependent protection against microsomal lipid peroxidation

1984 • 112 citations

Prevention of the acute ethanol-induced fatty liver by the simultaneous administration of antioxidants

1964 • 112 citations

The formation of mercapturic acids. 1. Formation of mercapturic acid and the levels of glutathione in tissues

1959 • 112 citations

Inhibition of Lipid Peroxidation in Microsomes by Vitamin E

1960 • 112 citations

An improved and simple method for determining diene conjugation in autoxidized polyunsaturated fatty acids

1983 • 112 citations

Metabolism of epoxidized phosphatidylcholine by phospholipase A₂ and epoxide hydrolase

1981 • 111 citations

The effect of vitamin C on in vivo lipid peroxidation in guinea pigs as measured by pentane and ethane production

1983 • 111 citations

Lipid peroxidation increases the molecular order of microsomal membranes

1984 • 111 citations

Inhibition of the ethanol and carbon tetrachloride induced fatty liver by antioxidants

1965 • 111 citations

Effect of vitamin E against adriamycin-induced toxicity in rabbits.

1980 • 111 citations

The identification, solubilization, and characterization of microsome-associated glutathione S-transferases.

1979 • 110 citations

Effects of replacement of the hydroxyl group of cholesterol and tocopherol on the thermotropic behavior of phospholipid membranes

1985 • 110 citations

Effects of dietary vitamin E, selenium, and polyunsaturated fats on in vivo lipid peroxidation in the rat as measured by pentane production

1978 • 110 citations

Destruction of sympathetic nerve terminals by 6-hydroxydopamine: protection by 1-phenyl-3-(2-thiazolyl)-2-thiourea, diethyldithiocarbamate, methimazole, cysteamine, ethanol and n-butanol.

1976 • 110 citations

Effects of 4-hydroxynonenal on isolated hepatocytes. Studies on chemiluminescence response, alkane production and glutathione status

1983 • 109 citations

In vivo studies on the relationship between target organ alkylation and the pulmonary toxicity of a chemically reactive metabolite of 4-ipomeanol.

1978 • 107 citations

Permeability of bilayer lipid membranes for superoxide (O2−) radicals

1984 • 107 citations

Reactive metabolites of phenacetin and acetaminophen: a review

1983 • 107 citations

A possible protective role for sulphydryl compounds in acute alcoholic liver injury

1977 • 106 citations

The Risk of Suicide in Mental Cases

1926 • 106 citations

A possible mechanism for the peroxidation of lipids due to chronic ethanol ingestion

1975 • 106 citations

Ozone and Vitamin E

1970 • 105 citations

Effect of antioxidants on lipid peroxidation in iron‐loaded rats

1984 • 104 citations

Mitochondrial iron not bound in heme and iron-sulfur centers. Estimation, compartmentation and redox state

1980 • 104 citations

Effect of in vivo and in vitro ethanol administration on liver lipid peroxidation.

1967 • 103 citations

Competition between transport of glutathione disulfide (GSSG) and glutathione S‐conjugates from perfused rat liver into bile

1982 • 100 citations

Role of vitamin E in glutathione-induced oxidant stress: methemoglobin, lipid peroxidation, and hemolysis

1977 • 100 citations

Depletion of renal glutathione content and nephrotoxicity of cephaloridine in rabbits, rats, and mice

1982 • 99 citations

Production of hydroxyl radicals from paraquat radicals and H₂O₂

1981 • 98 citations

Dissociation of cell death from covalent binding of paracetamol by flavones in a hepatocyte system

1982 • 98 citations

A function for α‐tocopherol: Stabilization of the microsomal membrane from radical attack during TPNH‐dependent oxidations

1971 • 98 citations

Acetaminophen hepatotoxicity

1983 • 96 citations

The oxidation of ferrous perchlorate by molecular oxygen

1954 • 96 citations

The role of lipid peroxidation and biological antioxidants in the function of the adrenal cortex. Part 1: A background review

1983 • 96 citations

The relevance of pentose phosphate pathway stimulation in rat lung to the mechanism of paraquat toxicity

1976 • 95 citations

Ethane production and liver necrosis in rats after administration of drugs and other chemicals

1979 • 95 citations

Halothane Hepatotoxicity: Relation Between Metabolic Activation, Hypoxia, Covalent Binding, Lipid Peroxidation and Liver Cell Damage

1983 • 94 citations

An Intracellular Transit Iron Pool

1977 • 94 citations

Chemistry of superoxide ion. 4. Singlet oxygen is not a major product of dismutation

1980 • 93 citations

Studies on peroxidized lipids. V. Formation and characterization of 1,4‐dihydropyridine‐3,5‐dicarbaldehydes as model of fluorescent components in lipofuscin

1984 • 93 citations

Oxygen-mediated cell injury in the killing of cultured hepatocytes by acetaminophen

1985 • 93 citations

Glutathione S‐Conjugate Transport Using Inside‐Out Vesicles from Human Erythrocytes

1982 • 93 citations

The hemolytic effect of primaquine. III. A study of primaquine-sensitive erythrocytes.

1954 • 92 citations

Paracetamol-induced hepatic necrosis in the mouse—Relationship between covalent binding, hepatic glutathione depletion and the protective effect of α-mercaptopropionylglycine

1977 • 92 citations

Protective Effect of β-Carotene against Lethal Photosensitization by Hæmatoporphyrin

1964 • 92 citations

Age-dependent changes in rat liver microsomal and mitochondrial NADPH-dependent lipid peroxidation

1977 • 91 citations

Membranes and their cellular functions

1974 • 91 citations

Paracetamol-stimulated lipid peroxidation in isolated rat and mouse hepatocytes

1983 • 91 citations

Cellular mixed disulphides between thiols and proteins, and their possible implication for radiation protection

1968 • 91 citations

Chelated iron-catalyzed OH. formation from paraquat radicals and H2O2: Mechanism of formate oxidation

1984 • 91 citations

Lipid peroxidation and paraquat toxicity

1979 • 90 citations

Effect of acute and chronic ethanol ingestion on the content of reduced glutathione of various tissues of the rat

1981 • 89 citations

Varying effects of sulfhydryl nucleophiles on acetaminophen oxidation and sulfhydryl adduct formation

1979 • 89 citations

The reaction of dna with lipid oxidation products, metals and reducing agents

1984 • 88 citations

Drug metabolism and drug toxicity

1984 • 88 citations

Tolerance Mechanisms

1967 • 87 citations

Superoxide, hydrogen peroxide, and oxygen toxicity in two free-living nematode species

1983 • 87 citations

Ueber die nach Einführung von Brombenzol und Chlorbenzol im Organismus entstehenden schwefelhaltigen Säuren

1879 • 87 citations

Differential effects of anthracycline drugs on rat heart and liver microsomal reduced nicotinamide adenine dinucleotide phosphate-dependent lipid peroxidation.

1982 • 86 citations

Inhibition of microsomal oxidation of alcohols and of hydroxyl-radical-scavenging agents by the iron-chelating agent desferrioxamine

1983 • 86 citations

The effect of inorganic iron on the thiobarbituric acid method for the determination of lipid peroxides

1964 • 86 citations

Carbon tetrachloride, bromotrichloromethane and ethanol acute intoxication. New chemical evidence for lipid peroxidation in rat tissue microsomes

1983 • 86 citations

Ueber Bromphenylmercaptursäure

1879 • 85 citations

Alteration of inner-membrane components and damage to electron-transfer activities of bovine heart submitochondrial particles induced by NADPH-dependent lipid peroxidation

1982 • 85 citations

Metabolic activation of nitrofurantoin—possible implications for carcinogenesis

1979 • 85 citations

The subcellular localization of aldehyde dehydrogenase in rat liver

1975 • 85 citations

Lipid peroxidation: A mechanism involved in acute ethanol toxicity as demonstrated by in vivo pentane production in the rat

1978 • 85 citations

Biochemical changes in the tissues of animals injected with iron. 3. Lipid peroxidation

1962 • 84 citations

Evidence for the production of hydroxyl radicals from the adriamycin semiquinone and H₂O₂

1981 • 83 citations

Lipid Peroxidation in Iron-Overloaded Spleens

1981 • 83 citations

The formation of mercapturic acids. 2. The possible role of glutathionase

1959 • 83 citations

Effect of hydroxyl radical scavengers on microsomal oxidation of alcohols and on associated microsomal reactions

1978 • 82 citations

Hepatotoxic metabolic activation of paracetamol and its derivatives phenacetin and benorilete: Oxygenation or electron transfer?

1981 • 82 citations

Mechanism of reactions involving singlet oxygen and the superoxide anion

1977 • 82 citations

Studies on the irreversible binding of 14CCCl4 to microsomal lipids in rats under varying experimental conditions

1972 • 81 citations

Carbon tetrachloride-induced lipid peroxidation of rat liver microsomes in vitro

1977 • 81 citations

Lipid peroxidation as a possible cause of TCDD toxicity

1983 • 81 citations

Studies on paracetamol-induced lipid peroxidation

1982 • 81 citations

The occurrence of protein-bound mixed disulfides in rat tissues

1973 • 81 citations

Spin trapping of free radicals during hepatic microsomal lipid peroxidation.

1981 • 81 citations

Glutathione-dependent inhibition of lipid peroxidation by a soluble, heat-labile factor in animal tissues

1980 • 80 citations

On the mechanism of paraquat action on microsomal oxygen reduction and its relation to lipid peroxidation

1979 • 80 citations

Species differences in carbon tetrachloride-induced hepatotoxicity: The role of CCl4 activation and of lipid peroxidation

1975 • 79 citations

ORAL METHIONINE IN THE TREATMENT OF SEVERE PARACETAMOL (ACETAMINOPHEN) OVERDOSE

1976 • 79 citations

Treating Acute Acetaminophen Poisoning With Acetylcysteine

1977 • 78 citations

Decrease of reduced glutathione in isolated rat hepatocytes caused by acrolein, acrylonitrile, and the thermal degradation products of styrene copolymers

1980 • 78 citations

Paraquat and NADPH-dependent lipid peroxidation in lung microsomes.

1981 • 77 citations

The non-protein thiol of rat liver mitochondria

1974 • 77 citations

The effect of paraquat on microsomal lipid peroxidation in vitro and in vivo

1980 • 77 citations

Generation of hydroxyl radicals during the enzymatic reductions of the Fe3+-ADP-Phosphate-adriamycin and Fe3+-ADP-EDTA systems

1983 • 76 citations

Studies on the microsomal formation of arylating metabolites of acetaminophen and phenacetin.

1977 • 76 citations

Studies on in vitro peroxidation of liver lipids in ethanol‐treated rats

1973 • 76 citations

Membranes and their cellular functions

1975 • 75 citations

Reduced Triphosphopyridine Nucleotide Oxidase-catalyzed Alterations of Membrane Phospholipids

1972 • 75 citations

THE ROLE OF ALCOHOLISM IN HEPATIC IRON STORAGE DISEASE*

1975 • 74 citations

Effects of N-acetylcysteine on the disposition and metabolism of acetaminophen in mice.

1985 • 74 citations

Biology of vitamin E

1983 • 74 citations

[61] Glutathione transferases: An overview

1985 • 74 citations

Effects of Ferrous Chloride and Iron-Dextran on Lipid Peroxidation in Vivo in Vitamin E and Selenium Adequate and Deficient Rats

1981 • 73 citations

The formation of mixed disulphides in rat lung following paraquat administration Correlation with changes in intermediary metabolism

1982 • 73 citations

Effects of vitamin E, ascorbic acid and mannitol on alloxan-induced lipid peroxidation in rats

1982 • 73 citations

Studies on vitamin E. 5. Lipid peroxidation in dialuric acid-induced haemolysis of vitamin E-deficient erythrocytes

1960 • 72 citations

Superoxide and hydrogen peroxide-dependent lipid peroxidation in intact and Triton-dispersed erythrocyte membranes

1984 • 72 citations

Selenium and drug metabolism—I

1983 • 72 citations

The role of lipid peroxidation in CCl4-induced damage to liver microsomal enzymes: Comparative studies in vitro using microsomes and isolated liver cells

1981 • 71 citations

The role of lipid peroxidation in the toxicity of foreign compounds to liver cells

1983 • 71 citations

Self-catalysed, O2-independent inactivation of nadph- or dithionite-reduced microsomal cytochrome P-450 by carbon tetrachloride

1981 • 70 citations

Lipid peroxidation induced by some halomethanes as measured by in vivo pentane production in the rat

1979 • 70 citations

Pigments in Pathology.

1969 • 69 citations

GSH‐dependent inhibition of lipid peroxidation: Properties of a potent cytosolic system which protects cell membranes

1985 • 69 citations

Some Factors Affecting the Release of Iron from Reticuloendothelial Cells

1971 • 69 citations

Potentiation of acute paraquat toxicity by vitamin E deficiency

1979 • 69 citations

Peroxidation of Liver Lipids in the Pathogenesis of the Ethanol-Induced Fatty Liver

1966 • 68 citations

Formation of age pigment-like fluorescent substances during peroxidation of lipids in model membranes.

1984 • 68 citations

Nitrofurantoin: Evidence for the Oxidant Injury of Lung Parenchymal Cells^1,2

1983 • 68 citations

Effect of acute ethanol ingestion on lipoperoxidation and on the activity of the enzymes related to peroxide metabolism in rat liver

1980 • 67 citations

Hepatic Microsomal Lipoperoxidation and Inhalation Anesthetics

1972 • 67 citations

Effects of thallium, nickel, and cobalt administration on the lipid peroxidation in different regions of the rat brain

1981 • 66 citations

Hepatic mitochondrial cytochrome P -450: Isolation and functional characterization

1977 • 66 citations

Inhibition of protein synthesis by carbonyl compounds (4-hydroxyalkenals) originating from the peroxidation of liver microsomal lipids

1981 • 65 citations

The role of iron in the paracetamol- and CCl4-induced lipid peroxidation and hepatotoxicity

1985 • 65 citations

Hydroperoxide-supported cytochrome P-450-linked fatty acid hydroxylation in liver microsomes

1975 • 65 citations

Protective role of S-adenosyl-l-methionine against acetaminophen induced mortality and hepatotoxicity in mice

1979 • 65 citations

Singlet oxygen formation during hemoprotein catalyzed lipid peroxide decomposition

1977 • 65 citations

Effect of hydrogen peroxide on the initiation of microsomal lipid peroxidation

1983 • 65 citations

ANTIOXIDANTS

1947 • 65 citations

The autoxidation of ferrous ions in aqueous solution

1953 • 65 citations

Mitochondrial electron transport and energy conservation

1972 • 65 citations

Mitochondrial lipid peroxidation by cumene hydroperoxide and its prevention by succinate

1982 • 64 citations

Enzymatic defenses against oxygen toxicity in the hydrothermal vent animals Riftia pachyptila and Calyptogena magnifica

1984 • 64 citations

Studies on the in vitro interaction of mitomycin C, nitrofurantoin and paraquat with pulmonary microsomes

1982 • 63 citations

Effect of ferrous ions on microsomal phospholipid peroxidation and related light emission

1974 • 63 citations

Lipid peroxidation as a mechanism of injury in cardiac myocytes.

1982 • 62 citations

Selenium and drug metabolism—II Independence of glutathione peroxidase and reversibility of hepatic enzyme modulations in deficient mice

1984 • 62 citations

Erythrocyte Glutathione-Peroxidase Deficiency

1970 • 62 citations

An in vitro model of liver injury using Paracetamol treatment of liver slices and prevention of injury by some antioxidants

1978 • 62 citations

The role of superoxide in xanthine oxidase-induced autooxidation of linoleic acid.

1982 • 62 citations

Influence of vitamin E and nitrogen dioxide on lipid peroxidation in rat lung and liver microsomes

1982 • 61 citations

The role of lipid peroxidation and antioxidants in ethanol-induced lipid alterations

1968 • 61 citations

Ethane exhalation as an index of in vivo lipid peroxidation: Concentrating ethane from a breath collection chamber

1982 • 60 citations

Liver cytosol catalyzed conjugation of reduced glutathione with a reactive metabolite of acetaminophen

1979 • 60 citations

The metabolism of acetophenetidine. Isolation and characterization of S-(1-acetamido-4-hydroxyphenyl)-cysteine, a metabolite of acetophenetidine

1964 • 60 citations

The Influence of Vitamin E on the Lung Fatty Acids of Rats Exposed to Ozone

1972 • 60 citations

Electron pin resonane of chromanoxy free radicals from α-, ζ2-, β-, γ-, δ-tocopherol and tocol

1971 • 59 citations

Effect of α-tocopherol upon lipid peroxidation and drug metabolism in hepatic microsomes

1966 • 59 citations

Dietary antioxidants and the biochemical response to oxidant inhalation

1982 • 58 citations

Drug Reactions and the Liver

1981 • 58 citations

SINGLET OXYGEN: A POSSTBLE SOURCE OF THE ORIGINAL HYDROPEROXIDES IN FATTY ACIDS

1970 • 58 citations

Decompostion of unsaturated phospholipid by iron-ADP-adriamycin co-ordination complex

1981 • 58 citations

Formation of age pigment-like fluorescent substances during peroxidation of lipids in model membranes

1984 • 57 citations

Some effects of ethanol and carbon tetrachloride on lipoperoxidation in rat liver

1969 • 56 citations

Carbon tetrachloride and bromotrichloromethane toxicity

1983 • 56 citations

Biochemical basis for the in vitro pro-oxidant action of carbon tetrachloride

1969 • 56 citations

Enhanced lung toxicity of paraquat in selenium-deficient rats

1978 • 56 citations

Electron spin resonance of chromanoxy free radicals from alpha, zeta, beta, gamma, delta-tocopherol and tocol.

1971 • 56 citations

Respective role of superoxide and hydroxyl radical in the activity of the reconstituted microsomal ethanol-oxidizing system

1978 • 56 citations

The effects of unsaturated fatty acids on hepatic microsomal drug metabolism and cytochrome P-450

1969 • 56 citations

Liver lipoperoxidative pressure and glutathione status following acetaldehyde and aliphatic alcohols pretreatments in the rat

1982 • 55 citations

Inhibition of hepatic microsomal lipid peroxidation by drug substrates without drug metabolism

1980 • 55 citations

Lack of evidence for N-hydroxyacetaminophen as a reactive metabolite of acetaminophen in vitro

1980 • 55 citations

Rainbow trout liver microsomal lipid peroxidation the effect of purified glutathione peroxidase, glutathione S-transferase and other factors

1984 • 54 citations

Effects of Vitamin E and Selenium on Copper-Induced Lipid Peroxidation in Vivo and on Acute Copper Toxicity

1982 • 54 citations

Lipid peroxidation and the concept of antioxygenic potential: Vitamin E changes in acute experimental CCl4-, BrCCl3-, and ethanol-induced liver injury

1977 • 54 citations

Studies of the mechanism of vitamin E action. V. Selenite and tocopherol inhibition of lipid peroxidation in the chick

1960 • 52 citations

[63] Glutathione transferase isoenzymes from rat liver cytosol

1985 • 52 citations

Role of glutathione depletion in the cytotoxicity of acetaminophen in a primary culture system of rat hepatocytes

1985 • 52 citations

Protection against Iron Toxicity in Vitamin E-deficient Piglets and Mice by Vitamin E and Synthetic Antioxidants

1964 • 52 citations

Some Physicochemical Aspects of Iron Metabolism

1977 • 51 citations

Release of ethane and pentane from rat tissue slices: Effect of vitamin E, halogenated hydrocarbons and iron overload

1984 • 51 citations

The mechanism of bromobenzene-induced cytotoxicity studied with isolated hepatocytes

1980 • 51 citations

A reaction between the superoxide free radical and lipid hydroperoxide in sodium linoleate micelles

1982 • 50 citations

Formaldehyde Dehydrogenase from Bakers' Yeast

1962 • 50 citations

Lipid peroxidation in chronic ethanol treated rats: In vitro uncoupling of peroxidation from reduced nicotine adenosine dinucleotide phosphate oxidation

1974 • 50 citations

Effects of Dietary Selenium and Vitamin E on Hepatic Mixed-Function Oxidase Activities and In Vivo Covalent Binding of Aflatoxin B1 in Rats

1982 • 50 citations

[36] Concentrating ethane from breath to monitor lipid peroxidation in vivo

1984 • 49 citations

The role of lipoperoxidation in the pathogenesis of fatty livers induced by phosphorus poisoning in rats.

1969 • 49 citations

Studies on glutathione transport utilizing inside-out vesicle prepared from human erythrocytes

1981 • 49 citations

The effects of antioxidants on high pressure oxygen toxicity

1964 • 49 citations

Oxidation of reduced glutathione by subcellular fractions of rat liver

1966 • 49 citations

Glutathione-dependent protection against oxidative damage of the human red cell membrane

1984 • 48 citations

Cadmium, methylmercury, mercury, and lead inhibition of calf liver glutathione S-transferase exhibiting selenium-independent glutathione peroxidase activity*1

1981 • 48 citations

Hepatic lipid peroxidation and mitochondrial susceptibility to peroxidative attacks during ethanol inhalation and withdrawal

1983 • 48 citations

Glutathione depletion increases chemiluminescence emission and lipid peroxidation in the heart

1984 • 47 citations

Mutagenicity tests of lipid oxidation products in Salmonella typhimurium: Monohydroperoxides and secondary oxidation products of methyl linoleate and methyl linolenate

1985 • 47 citations

Mechanism of lipid peroxide formation in polychlorinated biphenyls (PCB) and dichlorodiphenyltrichloroethane (DDT)-poisoned rats

1984 • 47 citations

Rapid depression of rat liver microsomal calcium pump activity after administration of carbon tetrachloride or bromotrichloromethane and lack of effect after ethanol

1981 • 47 citations

The protective effect of tinoridine against carbon tetrachloride hepatotoxicity

1980 • 47 citations

Inhibition of cephaloridine-induced lipid peroxidation

1985 • 46 citations

LIVER PARENCHYMAL CELL INJURY

1969 • 45 citations

Mitomycin C‐induced deoxyribose degradation inhibited by superoxide dismutase

1984 • 45 citations

Evidence for carbon tetrachloride-induced lipid peroxidation in mouse liver

1982 • 45 citations

Measurement of oxidized glutathione and total glutathione in the perfused rat heart

1970 • 45 citations

Direct Protection Against Acetaminophen Hepatotoxicity by Propylthiouracil

1981 • 45 citations

Iron nucleotides in human and rat red cells

1976 • 45 citations

Effect of Dietary Level of Ascorbic Acid on the Growth, Hepatic Lipid Peroxidation, and Serum Lipids in Guinea Pigs Fed Polychlorinated Biphenyls

1981 • 44 citations

Nitrofuran enhancement of microsomal electron transport, superoxide anion production and lipid peroxidation

1981 • 44 citations

Detection and measurement by high-performance liquid chromatography of malondialdehyde crosslinks in DNA

1984 • 44 citations

Loss of latent activity of liver microsomal membrane enzymes evoked by lipid peroxidation. Studies of nucleoside diphosphatase, glucose-6-phosphatase, and UDP glucuronyltransferase

1985 • 43 citations

Metabolism of acetanilides and anisoles with rat liver microsomes

1970 • 43 citations

Die Thiobarbitursäurezahl als Maß für den Oxydationsgrad von Nahrungsfetten

1959 • 42 citations

Chloroform-induced glutathione depletion and toxicity in freshly isolated hepatocytes

1980 • 42 citations

Evidence for lipid peroxidation by paraquat in the perfused rat lung.

1983 • 41 citations

Isolation from bovine liver mitochondria of a soluble ferredoxin active in a reconstituted steroid hydroxylation reaction

1977 • 41 citations

Selenium interactions with carcinogens

1983 • 40 citations

The effect of cysteine and N-acetyl cysteine on rat liver glutathione (GSH)

1983 • 40 citations

Metabolism of [p-18O]-phenacetin: the mechanism of activation of phenacetin to reactive metabolites in hamsters.

1979 • 40 citations

Kinetik des Malondialdehydes im Organismus

1965 • 39 citations

[37] Assay of ethane and pentane from isolated organs and cells

1984 • 39 citations

Protection against alloxan-induced diabetes by various urea derivatives: relationship between protective effects and reactivity with the hydroxyl radical.

1979 • 38 citations

Interactions of some acceptors with superoxide anion radicals formed by the NADPH-specific flavoprotein in rat liver microsomal fractions

1976 • 38 citations

Interrelation between alpha-tocopherol and protein metabolism; the protective effect of vitamin E and certain nitrogenous compounds against CCl4 poisoning in rats.

1948 • 38 citations

Ethylene Formation in Rat Liver Microsomes

1966 • 38 citations

Reduced Nicotinamide Adenine Dinucleotide Phosphate-dependent Lipid Peroxidation by Beef Heart Submitochondrial Particles1

1975 • 38 citations

Adrenal Gland in Vitamin E Deficiency

1968 • 38 citations

Ethane production of isolated perfused rat liver

1981 • 37 citations

Lipid peroxidation and the reduction of ADP-Fe3+ chelate by NADH-ubiquinone reductase preparation from bovine heart mitochondria

1980 • 37 citations

Dimethylurea: A radical scavenger that protects isolated pancreatic islets from the effects of alloxan and dihydroxyfumarate exposure

1980 • 37 citations

Anti-Vitamin E Stress Factors as Related to Lipid Peroxides

1955 • 37 citations

Cytotoxic Effects of N‐Hydroxyparacetamol in Suspensions of Isolated Rat Hepatocytes

1982 • 37 citations

Glutathione depletion by methyl chloride and association with lipid peroxidation in mice and rats

1984 • 36 citations

On the nature of cardio-active substances from ganglia

1969 • 36 citations

The effect of chronic alcohol feeding on lipid peroxidation in microsomes: Lack of relationship to hydroxyl radical generation

1984 • 36 citations

Lowered Resistance to Iron in Vitamin-E Deficient Piglets and Mice

1962 • 36 citations

Evidence for covalent binding of adriamycin to rat liver microsomal proteins

1981 • 35 citations

Nature of Aliphatic C-Nitroso Compounds. I. Study of the Rate of Dissociation of the Aliphatic C-Nitroso Dimer in Various Solvents

1957 • 35 citations

Evidence of peroxidative damage to the erythrocyte membrane in iron deficiency

1983 • 35 citations

Mechanism of the protective effect of propylthiouracil against acetaminophen (tylenol) toxicity in the rat

1980 • 35 citations

Hepatic free radical levels in ethanol-treated and carbon tetrachloride-treated rats

1971 • 35 citations

Interactive hepatotoxicity of chloroform and carbon tetrachloride

1982 • 35 citations

Toxicity of 1,2-dibromoethane in isolated hepatocytes: Role of lipid peroxidation

1984 • 34 citations

Lipid peroxidation, protein synthesis, and protection by calcium EDTA in paracetamol injury to isolated hepatocytes

1985 • 34 citations

Effect of Dietary Selenium Dioxide, Cystine, Ethoxyquin and Vitamin E on Lipid Autoxidation in Chick Tissues

1961 • 33 citations

Elevation of serum lipid peroxide level associated with doxorubicin toxicity and its amelioration by [dl]-?-tocopheryl acetate or coenzyme Q10 in mouse (doxorubicin, toxicity, lipid peroxide, tocopherol, coenzyme Q10)

1979 • 33 citations

Protection by gsh against lipid peroxidation induced by ascorbate and iron in rat liver microsomes

1982 • 33 citations

Adriamycin stimulates only the iron ion-induced, NADPH-dependent microsomal alkane formation

1982 • 32 citations

NADPH-driven lipid peroxidation in rat liver nuclei and nuclear membranes

1980 • 32 citations

Protective effect of propylthiouracil independent of its hypothyroid effect on acetaminophen toxicity in the rat.

1982 • 32 citations

Experimental acetaminophen-induced hepatic necrosis: biochemical and electron microscopic study of cysteamine protection.

1978 • 32 citations

Reaction of biological phenolic antioxidants with superoxide generated by cytochrome P-450 model system

1983 • 31 citations

Effect of vitamin E on carbon tetrachloride-induced lipid peroxidation as demonstrated by in vivo pentane production

1978 • 31 citations

Formation of lipid peroxides in isolated rat liver microsomes by singlet molecular oxygen

1977 • 31 citations

Controlled trial of cysteamine and dimercaprol after paracetamol overdose.

1977 • 31 citations

Vitamin E Protection of the Liver from Paracetamol in the Rat

1974 • 30 citations

Lipid peroxidation and cell damage in isolated hepatocytes due to bromotrichloromethane

1978 • 30 citations

Increased lipoperoxide content of orotic acid-induced fatty liver

1967 • 30 citations

Mitochondrial metabolism of aldehydes

1970 • 30 citations

OXIDATION OF PHOSPHOLIPID CATALYZED BY IRON COMPOUNDS WITH ASCORBIC ACID

1944 • 29 citations

Properties of Glutathione Disulfide (GSSG) and Glutathione-S-Conjugate Release from Perfused Rat Liver

1978 • 28 citations

Effect of Selenium and Vitamin E Deficiency on Nitrofurantoin Toxicity in the Chick

1982 • 28 citations

Ageing of Neurospora crassa. VIII. Lethality and mutagenicity of ferrous ions, ascorbic acid, and malondialdehyde

1979 • 28 citations

Alkane formation during liver microsomal lipid peroxidation

1982 • 28 citations

Production of volatile hydrocarbons by isolated hepatocytes: An in vitro model for lipid peroxidation studies

1981 • 28 citations

Membrane-bound glutathione peroxidase-like activity in mitochondria

1980 • 28 citations

Rat liver mitocrondrial cytochrome P‐450 active in a reconstituted steroid hydroxylation reaction

1978 • 27 citations

Drug-induced lipid peroxidation in mice—IV

1983 • 27 citations

Effect of substituents on in vitro metabolism and covalent binding of substituted bromobenzenes

1979 • 27 citations

Paracetamol Metabolism in the Rat: Relationship to Covalent Binding and Hepatic Damage

1976 • 27 citations

The microsomal metabolism of the organometallic derivatives of the group-IV elements, germanium, tin and lead

1981 • 27 citations

Reduction of ferricytochrome c, methemoglobin and metmyoglobin by hydroxyl and alcohol radicals

1979 • 26 citations

Lipid peroxidation in isolated rat hepatocytes measured by ethane and n-pentane formation

1982 • 26 citations

Microsomal (μS) lipid peroxidation, drug oxidations and chemiluminescence (CL): Mechanisms

1974 • 25 citations

Elevation of thiobarbituric acid values in the rat liver intoxicated by T-2 toxin

1984 • 25 citations

The influence of selenium intake on chronic adriamycin toxicity and lipid peroxidation in rats

1983 • 25 citations

Protective role of dietary butylated hydroxyanisole against chemical-induced acute liver damage in mice

1983 • 25 citations

Production of hydroxyl radicals and their role in the oxidation of ethanol by a reconstituted microsomal system containing cytochrome P-450 purified from phenobarbital-treated rats

1979 • 25 citations

An iron sulfur protein in the mitochondrial outer membrane, reducible by NADH and NADPH

1973 • 25 citations

Manipulation of mouse organ glutathione contents I: Enhancement by oral administration of butylated hydroxyanisole and butylated hydroxytoluene

1985 • 24 citations

The metabolism and toxicity of some organotin compounds in isolated rat hepatocytes

1982 • 24 citations

On the inhibition of microsomal drug metabolism by SKF 525-A

1972 • 23 citations

Evidence that lipid peroxidation in microsomal membranes of epidermis is associated with generation of hydrogen peroxide and singlet oxygen

1982 • 23 citations

The Toxicity of Parenteral Iron Preparations in the Rabbit and Pig with a Comparison of the Clinical and Biochemical Responses to Iron‐dextrose in 2 Days old and 8 Days old Piglets

1971 • 23 citations

Do the soluble glutathione S-transferases have direct access to membrane-bound substrates?

1983 • 22 citations

A comparison of NADPH and cumene hydroperoxide-stimulated lipid peroxidation in mouse hepatic microsomes

1981 • 22 citations

CYTOTOXIC ASPECTS OF THE INTERACTION OF ASCORBIC ACID WITH ALLOXAN AND 6‐HYDROXYDOPAMINE

1975 • 22 citations

Subcellular localization of adrenal cortical glutathione peroxidase and protective role of the mitochondrial enzyme against lipid peroxidative damage.

1985 • 22 citations

Turnover of Glutathione in Rat Liver

1978 • 22 citations

Oxidation of Reduced Nicotinamide-Adenine Dinucleotide Phosphate in Rat Liver Microsomes

1963 • 22 citations

Interactions of iron with biogenic amines and ATP

1976 • 21 citations

Effect of an Acute Dose of Ethanol on Lipid Peroxidation and on the Activity of Microsomal Glutathione S‐Transferase in Rat Liver

1983 • 21 citations

Enzyme-Generated Free Radicals as Initiators of Lipid Peroxidation in Biological Membranes

1976 • 21 citations

Fluorescent products and polyunsaturated fatty acids of human testes

1975 • 20 citations

NADPH-cytochrome c reductase in outer membrane of kidney mitochondria

1979 • 19 citations

Effects of sulphur-containing compounds on paracetamol activation and covalent binding in a mouse hepatic microsomal system

1980 • 19 citations

Determination of N,N'-Diphenyl-p-Phenylenediamine in Animal Tissues.

1960 • 18 citations

Influence of dietary vitamin E on the red cells of ozone-exposed rats

1979 • 18 citations

A kinetic assay of TPNH-dependent microsomal lipid peroxidation by changes in difference spectra

1973 • 18 citations

Singlet oxygen production associated with hydroperoxide induced lipid peroxidation in liver microsomes

1978 • 17 citations

Early events in guinea pig reticulocyte iron uptake

1981 • 17 citations

THE EFFECTS OF DRUGS ON ERYTHROCYTES in vitro: HEINZ BODY FORMATION, GLUTATHIONE PEROXIDASE INHIBITION AND CHANGES IN MECHANICAL FRAGILITY

1974 • 17 citations

In Vivo Incorporation of ⁶⁹Fe into Nonhem Iron and Hemoglobin of Red Blood Cells

1962 • 17 citations

Vitamin E Deficiency in Rats Given Succinyl Sulfathiazole in Purified Diets

1943 • 16 citations

Effect of alcohol on the liver of rats. 3. The role of lipid peroxidation and sulfhydryl compounds in ethanol-induced liver injury.

1970 • 16 citations

Glutathione Turnover in Isolated Hepatocytes

1978 • 16 citations

Lipid Peroxidation in Human Erythrocytes in Tocopherol Deficiency

1975 • 16 citations

Drug-induced Lipid Peroxidation in Mouse Liver

1978 • 16 citations

Ethane formation of isolated rat hepatocytes due to carbon tetrachloride

1981 • 16 citations

Formation of ethane in vitro by rat liver homogenates following glutathione depletion in vivo

1983 • 15 citations

BIOCHEMICAL CHANGES IN LUNGS EXPOSED TO PARAQUAT

1977 • 15 citations

OXYGEN POISONING AND VITAMIN E DEFICIENCY

1973 • 15 citations

The Relation of Pyridine Toxicity in Rats to Dietary Vitamin E

1953 • 15 citations

Functions of Glutathione in Liver and Kidney. Herausgegeben von H. SIES und A. WENDEL. 212 Seiten, 94 Abb. Springer-Verlag, Berlin, Heidelberg, New York 1978. Preis: 58,- DM; 31,90 $

1980 • 14 citations

A comparison of the protective effects of N-acetylcysteine and S-carboxymethylcysteine against paracetamol-induced hepatotoxicity

1983 • 14 citations

Chemically induced antioxidant‐sensitive respiration

1984 • 14 citations

Relationship between reduced nicotinamide adenine dinucleotide phosphate-dependent lipid peroxidation and drug hydroxylation in rat liver inicrosomes

1974 • 13 citations

Cocaine-Induced Hepatotoxicity: Lipid Peroxidation as a Possible Mechanism

1984 • 13 citations

Studies on lipid peroxidation using whole liver cells: Influence of damaged cells on the prooxidant effect of ADP-Fe3+ and CCl4

1981 • 13 citations

Iron induced oxidations in brain and other tissues

1941 • 13 citations

Chloroacetamide hepatotoxicity: Hydropic degeneration and lipid peroxidation

1980 • 13 citations

Carbon tetrachloride-induced lipid peroxidaton: Simultaneous in vivo measurements of pentane and chloroform exhaled by the rat

1981 • 12 citations

Changes in oxygen consumption induced by t-butyl hydroperoxide in perfused rat liver. Effect of free-radical scavengers

1984 • 12 citations

A sub-population of rat liver membrane-bound ribosomes that are detached in vitro by carcinogens and centrifugation

1978 • 12 citations

The effect of ionic strength on the lipid peroxidation of porcine intestinal brush-border membrane vesicles

1985 • 11 citations

Modification of Paracetamol Hepatotoxicity by Anti-Oxidants

1976 • 11 citations

Influence of paracetamol (acetaminophen) on cadmium-induced lipid peroxidation in hepatocytes from starved rats

1983 • 10 citations

Destruction of Microsomal Calcium Pump Activity: A Possible Secondary Mechanism in BrCCl3 and CCl4 Liver Cell Injury

1982 • 10 citations

Diverse effects of antioxidants on carbon tetrachloride hepatotoxicity

1975 • 9 citations

Pulmonary reactions to inhalation of methylene chloride: Effects on lipid peroxidation in rats

1981 • 8 citations

Regulation of the Hepatic Concentration of Reduced Glutathione

1978 • 8 citations

Organophosphate pesticide dichlorvos-induced increase in the rate of lipid peroxidation in the different regions of the rat brain: supporting ultrastructural findings.

1981 • 8 citations

ENHANCEMENT OF NADPH-DEPENDENT LIPID PEROXIDATION ACTIVITY BY ETHYLENE-DIAMINETETRAACETIC ACID (EDTA) IN THE PRESENCE OF FERROUS ION IN RABBIT LIVER MICROSOMES

1977 • 8 citations

Glutathione Peroxidase Deficiency with Increased Susceptibility to Erythrocyte Heinz Body Formation

1974 • 8 citations

Inhibitory action of macrocyclic polyamines on lipid peroxidation in rat liver microsomes

1982 • 7 citations

Development of the cytosolic defence system against microsomal lipid peroxidation in rat liver

1983 • 7 citations

Modification of Paracetamol Toxicity by Antioxidants

1976 • 6 citations

Modulation of N‐Hydroxyparacetamol Cytotoxicity in Suspensions of Isolated Rat Hepatocytes

1982 • 6 citations

Prevention of acetaminophen hepatotoxicity by propylthiouracil in the glutathione depleted rat

1983 • 6 citations

Influence of a low-selenium diet on erythrocyte glutathione peroxidase and alkane production in exhaled air of rats as a measure of lipid peroxidation in vivo during growth

1982 • 5 citations

LIPID PEROXIDATION IN MODEL AND NATURAL MEMBRANES

1979 • 5 citations

Cytosol-dependent control of lipid peroxidation

1982 • 4 citations

Untersuchungen über autoxydable Substanzen und autoxydable Systeme von physiologischem Interesse

1911 • 3 citations