Metabolic activation of nitrofurantoin—possible implications for carcinogenesis

DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION

1949 • 16,078 citations

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

1970 • 1,464 citations

Microsomal Triphosphopyridine Nucleotide-Cytochrome c Reductase of Liver

1962 • 909 citations

Carbon Tetrachloride Hepatotoxicity: An Example of Lethal Cleavage

1973 • 729 citations

Evidence for the Clara cell as a site of cytochrome P450-dependent mixed-function oxidase activity in lung

1977 • 359 citations

Biochemical Mechanisms of Drug Toxicity

1974 • 337 citations

The role of catalytic superoxide formation in the O2 inhibition of nitroreductase

1975 • 306 citations

Xanthine oxidase type D (dehydrogenase) in the intestine and other organs of the rat

1972 • 201 citations

Mechanism of microsomal and mitochondrial nitroreductase. Electron spin resonance evidence for nitroaromatic free radical intermediates

1975 • 195 citations

Mode of Action of Nitrofurazone

1970 • 193 citations

The enzymatic reduction of the N-hydroxy derivatives of 2-acetylaminofluorene and related carcinogens by tissue preparations.

1965 • 156 citations

Relationships between the carcinogenic and mutagenic or DNA-modifying effects of nitrofuran derivatives, including 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, a food additive.

1974 • 143 citations

2,3-Dihydro-2,3-dihydroxy-aflatoxin B1: An acid hydrolysis product of an RNA-aflatoxin B1 adduct formed by hamster and rat liver microsomes in vitro

1973 • 128 citations

Nitroreduction of 5-nitrofuran derivatives by rat liver xanthine oxidase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase

1974 • 124 citations

Nitroreductase activity of mammalian liver aldehyde oxidase.

1973 • 121 citations

Activation of nitrofurantoin to a mutagen by rat liver nitroreductase

1976 • 120 citations

On the interaction of N-2-fluorenylhydroxylamine with nucleic acids in, vitro

1965 • 117 citations

The Role of the Gut Flora in the Metabolism of Prontosil and Neoprontosil in the Rat

1971 • 110 citations

The carcinogenic activity of some 5-nitrofuran derivatives in the rat.

1969 • 107 citations

Hepatic necrosis caused by furosemide

1974 • 101 citations

Role of metabolic activation in the pathogenesis of chemically induced pulmonary disease: mechanism of action of the lung-toxic furan, 4-ipomeanol.

1976 • 77 citations

On the metabolic activation of N-hydroxy-N-2-acethylamino-fluorene☆☆☆II. Simultaneous formation of 2-nitrosofluorene and N-acetoxy-N-2-acetylaminofluorene from N-hydroxy-N-2-acetylaminofluorenevia a free radical intermediate

1971 • 76 citations

Reduction of niridazole by rat liver xanthine oxidase

1971 • 74 citations

The possible involvement of cytochrome b5 in the oxidation of lauric acid by microsomes from kidney cortex and liver of rats

1974 • 67 citations

Mutagen screening with bacteria: Niridazole and nitrofurans

1975 • 64 citations

Metabolic Degradation of the Nitrofurans

1960 • 60 citations

METABOLISM OF THE NITROFURANS

1951 • 58 citations

Enhancement of the Antitumor Effect of 1,3-Bis(2-Chloroethyl)- 1-Nitrosourea by Chlorpromazine and Caffeine2

1973 • 57 citations

“Activation” of nitrofurazone in animal tissues

1971 • 56 citations

Activation and inactivation of chemical carcinogens and mutagens in the mammal.

1974 • 51 citations

Reductive metabolism of nitrofurantoin in the rat.

1978 • 51 citations

Reduction of nitrofuran derivatives by xanthine oxidase and microsomes

1976 • 48 citations

Distribution, excretion, and binding of radioactivity in the rat after intraperitoneal administration of the lung-toxic furan, 614C94-ipomeanol*1

1975 • 47 citations

Mechanism of stimulation of mammalian nitro reductase by flavins

1963 • 46 citations

Mutagenic activity of carcinogenic and noncarcinogenic nitrofurans and of urine of rats fed these compounds

1976 • 31 citations

Comparative carcinogenicity in the rat of 2-hydrazinothiazoles with nitrofuryl, nitrophenyl, or aminophenyl substituents in the 4-position.

1970 • 28 citations

Comparative studies of rat liver and lung NADPH-cytochrome c reductase

1975 • 28 citations

Enzyme-catalysed reactions between some 2-substituted 5-nitrofuran derivatives and glutathione

1970 • 27 citations

Metabolism of Drugs. LXXX. The Metabolic Fate of Nitrofuran Derivatives.(3). Studies on Enzymes in Small Intestinal Mucosa of Rat Catalyzing Degradation of Nitrofuran Derivatives

1973 • 21 citations

Metabolism and disposition of N-(4-(5-nitro-2-furyl)-(2-14-C)thiazolyl)acetamide in the rat.

1975 • 16 citations