Free Radical Mechanisms of Lipid Damage and Consequences for Cellular Membranes

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Carbon tetrachloride hepatotoxicity.

1967 • 980 citations

Oxygen Poisoning and X-irradiation: A Mechanism in Common

1954 • 917 citations

The thiobarbituric acid reaction and the autoxidations of polyunsaturated fatty acid methyl esters

1962 • 823 citations

Evidence that Peroxidation of Lysosomal Membranes Is Initiated by Hydroxyl Free Radicals Produced during Flavin Enzyme Activity

1973 • 663 citations

THE REACTION BETWEEN THIOBARBITURIC ACID AND THE OXIDATION PRODUCTS OF CERTAIN LIPIDES

1948 • 635 citations

The stimulatory effects of carbon tetrachloride and other halogenoalkanes on peroxidative reactions in rat liver fractions in vitro. General features of the systems used

1971 • 538 citations

Lipid peroxide formation in microsomes. General considerations

1969 • 528 citations

Cellular mechanisms of oxygen toxicity.

1968 • 515 citations

Present Knowledge in Nutrition

2020 • 513 citations

ADP-activated lipid peroxidation coupled to the TPNH oxidase system of microsomes

1963 • 512 citations

VITAMIN E AND FREE RADICAL PEROXIDATION OF LIPIDS*

1972 • 471 citations

An enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone‐exposed rats

1972 • 350 citations

Free Radical Theory of Aging: Effect of Free Radical Reaction Inhibitors on the Mortality Rate of Male LAF1 Mice

1968 • 339 citations

Rate And Magnitude Of Age Pigment Accumulation In The Human Myocardium

1959 • 336 citations

Mechanisms of lipid peroxide formation in tissues Role of metals and haematin proteins in the catalysis of the oxidation of unsaturated fatty acids

1965 • 293 citations

Will antioxidant nutrients slow aging processes?

1968 • 279 citations

Lipoperoxidation of Lung Lipids in Rats Exposed to Nitrogen Dioxide

1968 • 251 citations

Damage to proteins, enzymes, and amino acids by peroxidizing lipids

1966 • 214 citations

Fluorescent products of lipid peroxidation of mitochondria and microsomes

1971 • 208 citations

Peroxidation of Subcellular Organelles: Formation of Lipofuscinlike Fluorescent Pigments

1969 • 201 citations

Cytochrome P-450 as a microsomal peroxidase utilizing a lipid peroxide substrate

1971 • 200 citations

Peroxidation of Body Fat in Vitamin E Deflciency

1945 • 194 citations

Inhibition of the TPNH-linked lipid peroxidation of liver microsomes by drugs undergoing oxidative demethylation

1964 • 191 citations

Free Radicals in Biological Systems

1970 • 174 citations

Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450

1974 • 173 citations

Oxidation of Unsaturated Fatty Acids by Ozone and Nitrogen Dioxide

1971 • 162 citations

Peroxidation of lipids in tissue homogenates as related to vitamin E

1960 • 162 citations

Reduced Triphosphopyridine Nucleotide Oxidase-catalyzed Alterations of Membrane Phospholipids

1968 • 144 citations

Oxidation by Molecular Oxygen. II. The Oxygen Atom Transfer Mechanism for Mixed-Function Oxidases and the Model for Mixed-Function Oxidases

1964 • 130 citations

Die Fluoreszenz tierischer Gewebe in ultraviolettem Licht

1911 • 128 citations

Lipid oxidation in biological membranes

1970 • 117 citations

Toxicity of Air-Oxidized Soybean Oil

1960 • 113 citations

Toxicity of autoxidized squalene and linoleic acid, and of simpler peroxides, in relation to toxicity of radiation

1957 • 104 citations

A function for α‐tocopherol: Stabilization of the microsomal membrane from radical attack during TPNH‐dependent oxidations

1971 • 98 citations

The inhibitory effects in vitro of phenothiazines and other drugs on lipid-peroxidation systems in rat liver microsomes, and their relationship to the liver necrosis produced by carbon tetrachloride

1968 • 97 citations

Lipid peroxidation in rat tissue homogenates: Interaction of iron and ascorbic acid as the normal catalytic mechanism

1966 • 91 citations

Studies on ageing in nematodes IV. The effect of anti-oxidants on cellular damage and life span

1972 • 81 citations

The Irradiation-Induced Autoxidation of Linoleic Acid

1952 • 75 citations

Measurement and Spectral Characteristics of Fluorescent Pigments in Tissues of Rats as a Function of Dietary Polyunsaturated Fats and Vitamin E

1973 • 67 citations

NON-CALORIC FUNCTIONS OF DIETARY FATS

1943 • 63 citations

The effect of oxidized fatty acids on the activity of certain oxidative enzymes

1952 • 62 citations

The peroxidase nature of cytochrome P-420 utilizing a lipid peroxide substrate

1971 • 59 citations

Non-enzymatic Ethanol Oxidation in Biological Extracts.

1973 • 59 citations

On the postulated peroxidation of unsaturated lipids in the tissues of vitamin E-deficient rats

1968 • 48 citations

Studies on Vitamin E Action: Peroxidation Inhibition in Structural Protein-lipid Micelle Complexes Derived from Rat Liver Microsomal Membranes

1970 • 46 citations

The Effect of X-Irradiation on the Antioxidant Activity of Mammalian Tissues

1959 • 40 citations

Effects of surface concentration, metals and acid synergists on autoxidation of linoleic acid monolayers on silica

1972 • 37 citations

Enzymic activities of lipofuscin age pigments: Comparative histochemical and biochemical studies

1965 • 31 citations

THE OXIDATION OF UNSATURATED FATTY ACID IN NORMAL AND SCORBUTIC GUINEA PIGS

1949 • 30 citations

Aging Research (I): Cellular Theories of Senescence

1974 • 30 citations

Autoxidation of drying oils adsorbed on porous solids

1951 • 29 citations

Autoxidation of polyunsaturated fatty esters on Silica

1973 • 28 citations

The Effect of Selenium on Vitamin E‐deficient Rats.

1958 • 21 citations

UV Spectrophotometry of autoxidized lipid monolayers while on silica gel

1971 • 18 citations

STUDIES ON THE TOXICITY OF FISH OIL. II*

1954 • 15 citations

Stability of unsaturated methyl esters of fatty acids on surfaces

1972 • 13 citations

Vitamin E and its role in cellular metabolism

1972 • 12 citations