Toxic drug effects associated with oxygen metabolism: Redox cycling and lipid peroxidation

The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase

1972 • 8,501 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Free Radicals in Biology

1976 • 1,879 citations

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

1980 • 1,094 citations

Ciba Foundation Symposium

1965 • 1,026 citations

Role of superoxide dismutase in cancer: a review.

1979 • 976 citations

The Generation of Hydrogen Peroxide, Superoxide Radical, and Hydroxyl Radical by 6-Hydroxydopamine, Dialuric Acid, and Related Cytotoxic Agents

1974 • 894 citations

Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity.

1980 • 757 citations

Enzymatic Basis of Detoxication

1980 • 717 citations

Oxygen Activation and Oxygen Toxicity

1982 • 713 citations

Enzymatic Defenses of the Mouse Heart Against Reactive Oxygen Metabolites

1980 • 711 citations

Intracellular production of superoxide radical and of hydrogen peroxide by redox active compounds

1979 • 595 citations

Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells.

1981 • 552 citations

Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity.

1979 • 538 citations

Chemicals, Drugs, and Lipid Peroxidation

1976 • 520 citations

Autoxidation of polyunsaturated fatty acids: II. A suggested mechanism for the formation of TBA‐reactive materials from prostaglandin‐like endoperoxides

1976 • 512 citations

Free Radical Mechanisms of Lipid Damage and Consequences for Cellular Membranes

1976 • 465 citations

Oxygen Radicals, Hydrogen Peroxide, and Oxygen Toxicity

1976 • 430 citations

DNA strand scission by enzymically generated oxygen radicals

1981 • 428 citations

Lipid hydroperoxide reactivity with proteins and amino acids: a review

1979 • 424 citations

The mechanism of NADPH-dependent lipid peroxidation. The propagation of lipid peroxidation.

1979 • 390 citations

Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation.

1977 • 365 citations

Mutagenicity of Malonaldehyde, a Decomposition Product of Peroxidized Polyunsaturated Fatty Acids

1976 • 356 citations

Biochemical Mechanisms of Drug Toxicity

1974 • 337 citations

Spin-trapping and direct electron spin resonance investigations of the redox metabolism of quinone anticancer drugs

1980 • 317 citations

Spontaneous cancer and its possible relationship to oxygen metabolism.

1980 • 298 citations

Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo

1979 • 298 citations

The hypoxic tumor cell: A target for selective cancer chemotherapy

1980 • 291 citations

Liver Necrosis and Lipid Peroxidation in the Rat as the Result of Paraquat and Diquat Administration

1980 • 284 citations

Role of superoxide in deoxyribonucleic acid strand scission

1980 • 276 citations

Reviews in biochemical toxicology

1979 • 274 citations

Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents

1977 • 258 citations

Alloxan-induced diabetes—evidence for hydroxyl radical as a cytotoxic intermediate

1976 • 249 citations

Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine.

1980 • 231 citations

Evidence for the involvement of N-ACETYL-p-quinoneimine in acetaminophen metabolism

1979 • 221 citations

Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells.

1980 • 220 citations

Antioxidants and Cancer. IV. Initiating Activity of Malonaldehyde as a Carcinogen

1974 • 213 citations

Bioactivation of carbon tetrachloride, chloroform and bromotrichloromethane: Role of cytochrome P-450

1977 • 199 citations

Hypoxia-dependent reduction of 1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol by Chinese hamster ovary cells and KHT tumor cells in vitro and in vivo.

1976 • 195 citations

Evidence for superoxide generation by NADPH-cytochrome C reductase of rat liver microsomes

1972 • 193 citations

Deficient metabolic utilization of hydrogen peroxide in Trypanosoma cruzi

1980 • 191 citations

Bleomycin: Chemical, Biochemical, and Biological Aspects

1979 • 186 citations

Vitamin E and Lipid Antioxidants in Free-Radical-Initiated Reactions

1980 • 180 citations

Binding of¹⁴C-Carbon Tetrachloride to Microsomal Proteinsin vitroand Formation of CHCl₃by Reduced Liver Microsomes

1973 • 177 citations

Formation of superoxide and hydroxy radicals in iron(II)-bleomycin-oxygen system: Electron spin resonance detection by spin trapping.

1978 • 175 citations

An Animal Model of Halothane Hepatotoxicity

1979 • 172 citations

Structure and Reactivity of Melanins: Influence of Free Radicals and Metal Ions

1980 • 171 citations

The production of hydroxyl radical by bleomycin and iron (II)

1979 • 168 citations

Confirmation of assignment of the trichloromethyl radical spin adduct detected by spin trapping during 13C-carbon tetrachloride metabolism , , , ,

1980 • 165 citations

Oxidation of arachidonic acid in micelles by superoxide and hydrogen peroxide.

1981 • 160 citations

Benzo[a]pyrenedione/benzo[a]pyrenediol oxidation-reduction couples and the generation of reactive reduced molecular oxygen

1977 • 158 citations

Relationship of the single-electron reduction potential of quinones to their reduction by flavoproteins

1980 • 154 citations

Critical role of lipid peroxidation in carbon tetrachloride-induced loss of aminopyrine demethylase, cytochrome P-450 and glucose 6-phosphatase

1976 • 151 citations

Mechanism of bleomycin action: studies

1981 • 145 citations

VITAMIN E AND SELENIUM PROTECTION FROM IN VIVO LIPID PEROXIDATION*

1980 • 145 citations

Regulatory role of glutathione and soluble sulfhydryl groups in the toxicity of adriamycin.

1980 • 145 citations

Biochemical mechanisms of liver injury

1970 • 144 citations

Chemical Mechanisms in Carbon Tetrachloride Toxicity

1977 • 136 citations

Comparison of the mutagenicities of malondialdehyde and the side products formed during its chemical synthesis.

1980 • 132 citations

Degradation of deoxyribonucleic acid by a 1,10-phenanthroline-copper complex: the role of hydroxyl radicals

1980 • 132 citations

Lipofuscin: Fine-Structural and Biochemical Studies

1977 • 115 citations

The mechanism of chloroform and carbon monoxide formation from carbon tetrachloride by microsomal cytochrome P-450

1980 • 114 citations

Ultraweak chemiluminescence: a sensitive assay for oxidative radical reactions.

1981 • 112 citations

Inhibition of lipid peroxidation without prevention of cellular injury in isolated rat hepatocytes

1981 • 106 citations

Metabolic activation of halothane and its covalent binding to liver endoplasmic proteins in vitro

1973 • 105 citations

Toxicity of Nitro Compounds Toward Hypoxic Mammalian Cells In Vitro: Dependence on Reduction Potential

1980 • 104 citations

The reduction of polyhalogenated methanes by liver microsomal cytochrome P450.

1977 • 104 citations

Biochemical Mechanisms of Liver Injury.

1979 • 103 citations

Hydroxyl radical production by free and DNA-bound aminoquinone antibiotics and its role in DNA degradation. Electron spin resonance detection of hydroxyl radicals by spin trapping

1978 • 98 citations

Measurement of and Protection from in Vivo Lipid Peroxidation

1980 • 97 citations

Metabolism of carbon tetrachloride in hepatic microsomes and reconstituted monooxygenase systems and its relationship to lipid peroxidation.

1980 • 96 citations

Low-Level Chemiluminescence of Isolated Hepatocytes

1981 • 93 citations

Effect of oxygen concentration on the reaction of halothane with cytochrome P450 in liver microsomes and isolated perfused rat liver

1978 • 88 citations

Biological reactive intermediates--II. Chemical mechanisms and biological effects.

1981 • 84 citations

Hepatotoxic metabolic activation of paracetamol and its derivatives phenacetin and benorilete: Oxygenation or electron transfer?

1981 • 82 citations

Studies on the irreversible binding of 14CCCl4 to microsomal lipids in rats under varying experimental conditions

1972 • 81 citations

A comparative study on the irreversible binding of labeled halothane trichlorofluoromethane, chloroform, and carbon tetrachloride to hepatic protein and lipids in vitro and in vivo

1975 • 78 citations

Hepatic Necrosis Caused by Halothane and Hypoxia in Phenobarbital-treated Rats

1979 • 78 citations

The Involvement of Free Radicals in Chemical Carcinogenesis

1977 • 78 citations

The effect of paraquat on microsomal lipid peroxidation in vitro and in vivo

1980 • 77 citations

β-lapachone enhancement of lipid peroxidation and superoxide anion and hydrogen peroxide formation by Sarcoma 180 ascites tumor cells

1979 • 75 citations

Enhancement of bleomycin—iron free radical damage to DNA by antioxidants and their inhibition of lipid peroxidation

1981 • 75 citations

Functions of intracellular glutathione in hepatic hydroperoxide and drug metabolism and the role of extracellular glutathione

1980 • 74 citations

The free radical oxidation of polyunsaturated lecithins

1980 • 72 citations

Spin trapping of free radical products of CCI₄ activation using pulse radiolysis and high energy radiation procedures

1980 • 70 citations

Self-catalysed, O2-independent inactivation of nadph- or dithionite-reduced microsomal cytochrome P-450 by carbon tetrachloride

1981 • 70 citations

Irreversible binding of dopa and dopamine metabolites to protein by rat liver microsomes

1975 • 69 citations

Hepatic Microsomal Lipoperoxidation and Inhalation Anesthetics

1972 • 67 citations

Free-Radical Damage in Liver

1980 • 67 citations

Comparative flavoprotein catalysis of anthracycline antibiotic. Reductive cleavage and oxygen consumption.

1981 • 58 citations

Covalent binding of carbon tetrachloride metabolites to liver nuclear DNA, proteins, and lipids*1, *2

1980 • 56 citations

Oxygen dependence of CCl4-induced lipid peroxidation in vitro and in vivo

1980 • 52 citations

Reviews in biochemical toxicology, vol. 3

1982 • 51 citations

New developments on the mechanisms of action of antineoplastic drugs

1979 • 49 citations

O₂‐independent damage of cytochrome P450 by CCl₄‐metabolites in hepatic microsomes

1980 • 48 citations

Selective toxicity of 5-S-cysteinyldopa, a melanin precursor, to tumor cells in vitro and in vivo.

1980 • 46 citations

Mechanism of the microsomal reduction of carbon tetrachloride and halothane

1981 • 46 citations

Redox cycling of Fe(III)-bleomycin by NADPH-cytochrome P-450 reductase

1981 • 45 citations

Redox cycle of stable mixed nitroxides formed from carcinogenic aromatic amines

1980 • 44 citations

Differential cytotoxicity of daunomycin in tumour cells is related to glutathione-dependent hydrogen peroxide metabolism

1981 • 44 citations

Superoxide production by purified hamster hepatic nuclei.

1980 • 43 citations

Studies related to antitumor antibiotics. Part XIII. Reactivity of 2- and 3-indolylcarbinyl compounds as models for mitosane action

1978 • 42 citations

Ethane production of isolated perfused rat liver

1981 • 37 citations

Influence of hypoxia on the hepatotoxic effects of carbon tetrachloride, paracetamol, allyl alcohol, bromobenzene and thioacetamide

1980 • 37 citations

Determination of malondialdehyde-DNA crosslinks by fluorescence and incorporation of tritium

1981 • 37 citations

Production of Radicals from Enzyme Systems and the Use of Spin Traps

1980 • 35 citations

Lack of in vivo lipid peroxidation in experimental paraquat poisoning

1980 • 35 citations

Bleomycin toxicity

1980 • 28 citations

Pyridinyl Radicals in Biology

1976 • 28 citations

Ketone Reductases

1980 • 25 citations

Active oxygen in liver microsomes: mechanism of epinephrine oxidation.

1979 • 24 citations

ISOBUTENE FORMATION DURING HALOTHANE ANAESTHESIA IN MAN

1980 • 23 citations

Paraquat-induced alterations of phospholipids and GSSG-release in the isolated perfused rat liver, and the effect of SOD-active copper complexes

1981 • 23 citations

Evidence for a functional oxygen‐bound intermediate in the reaction of Escherichia coli cytochrome o with oxygen

1979 • 22 citations

Daunorubicin reduction mediated by aldehyde and ketone reductases

1981 • 21 citations

Free Radicals in Arylamine Carcinogenesis

1980 • 20 citations

The Role of NADPH-Cytochrome c (P-450) Reductase in Detoxication

1980 • 20 citations

Microsomal NADPH-dependent lipid peroxidation does not require the presence of intact cytochrome P450

1980 • 19 citations

Conversion of benzo[a]pyrene‐3,6‐quinone to quinol glucuronides with rat liver microsomes or purified nadph‐cytochrome c reductase and UDP‐glucuronosyltransferase

1980 • 19 citations

The Effect of High Concentrations of Oxygen on Paraquat and Diquat Toxicity in Rats

1980 • 19 citations

Role of biotransformation in the toxicity of inhalation anesthetics

1978 • 19 citations

Long-Range Effects of Products of Carbon Tetrachloride-Stimulated Lipid Peroxidation

1976 • 18 citations

Stoichiometry of the mixed function oxidase

1979 • 18 citations

Irreversible binding of 5-hydroxytryptamine and 5-hydroxytryptophan metabolites to rat liver microsomal protein.

1979 • 16 citations

Ethane formation of isolated rat hepatocytes due to carbon tetrachloride

1981 • 16 citations

Interaction of epinephrine metabolites with the liver microsomal electron transport system.

1977 • 15 citations

Aldehyde Reductase

1980 • 14 citations

Acute adriamycin treatment of rats does not increase ethane expiration.

1980 • 13 citations

Metabolism of benzo[a]pyrene‐3,6‐quinone by isolated hepatocytes

1980 • 13 citations

A rationale for the design of cell‐specific toxic agents: The mechanism of action of 6‐hydroxydopamine

1976 • 10 citations

Lysis of erythrocytes as a result of microsomal lipid peroxidation induced by CCl4 or FeCl2.

1980 • 9 citations

Lipid Peroxidation Induced by Ethanol and Halogenated Hydrocarbons in vivo as Measured by Ethane Exhalation

1978 • 9 citations

Influence of oxygen on the inhibition of liver microsomal activation of carbon tetrachloride by the catechol 2-hydroxyestradiol-17β

1981 • 8 citations

In-vivo inhibition by copper and some Cu-complexes of paracetamol-induced lipid peroxidation in benzpyrene-pretreated mice.

1980 • 5 citations

ALTERATION OF FORCED DUCTION TESTING BY SUCCINYLCHOLINE

1979 • 4 citations

Effect of hypoxia on the cytotoxicity of misonidazole in HELA S3 cells in vitro.

1980 • 4 citations