Reactive metabolites of phenacetin and acetaminophen: a review

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.

1973 • 1,717 citations

Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.

1973 • 1,467 citations

Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.

1973 • 1,174 citations

Acetaminophen-induced Hepatic Necrosis

1974 • 1,021 citations

Acute liver necrosis following overdose of paracetamol.

1966 • 525 citations

Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.

1973 • 500 citations

N-hydroxy-2-acetylaminofluorene sulfotransferase: its probable role in carcinogenesis and in protein-(methion-S-yl) binding in rat liver.

1970 • 354 citations

LIVER NECROSIS FROM PARACETAMOL

1966 • 304 citations

Acetaminophen-induced hepatotoxicity

1981 • 164 citations

Carcinoma of the renal pelvis in renal papillary necrosis.

1965 • 135 citations

Malignancies of the urinary tract and their relation to analgesic abuse

1978 • 105 citations

Generation of reactive metabolites of N-hydroxy-phenacetin by glucuronidation and sulfation

1977 • 101 citations

N-hydroxyacetaminophen: A microsomal metabolite of N-hydroxyphenacetin but apparently not of acetaminophen

1979 • 83 citations

Analgesic Abuse and Renal Disease

1975 • 82 citations

Studies on the microsomal formation of arylating metabolites of acetaminophen and phenacetin.

1977 • 76 citations

Tumors of Sprague-Dawley rats induced by long-term feeding of phenacetin.

1979 • 72 citations

3-Hydroxyacetaminophen: a microsomal metabolite of acetaminophen. Evidence against an epoxide as the reactive metabolite of acetaminophen.

1980 • 65 citations

N-Hydroxylation of phenacetin by hamster liver microsomes.

1976 • 62 citations

Conversion of the N-O-glucuronide and N-O-sulfate conjugates of N-hydroxyphenacetin to reactive intermediates

1978 • 60 citations

Toxic Drug Reactions

1975 • 51 citations

Metabolism of acetanilides and anisoles with rat liver microsomes

1970 • 43 citations

N-Hydroxylation of p-acetophenetidide as a factor in nephrotoxicity

1973 • 41 citations

Metabolism of [p-18O]-phenacetin: the mechanism of activation of phenacetin to reactive metabolites in hamsters.

1979 • 40 citations

Liver and Kidney Damage Induced byN-Hydroxyparacetamol

1978 • 33 citations

Microsomal N-Hydroxylation of p-Chloroacetanilide

1975 • 32 citations

Renal disease due to analgesics. I. Recognition of the problem of analgesic nephropathy.

1972 • 28 citations

Synthesis of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen, and its phenolic sulfate conjugate

1978 • 27 citations

N-hydroxylation of p-chloroacetanilide in hamsters

1976 • 20 citations

The formation of arylating and alkylating metabolites of phenacetin in hamsters and hamster liver microsomes.

1981 • 20 citations

Kinetic Evidence for Multiple Chemically Reactive Intermediates in the Breakdown of Phenacetin N-O-Glucuronide

1979 • 14 citations