Acetaminophen hepatotoxicity

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.

1973 • 1,717 citations

Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.

1973 • 1,467 citations

The Glutathione Status of Cells

1978 • 1,218 citations

The Reduction of Cytochrome c by Milk Xanthine Oxidase

1968 • 1,201 citations

Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.

1973 • 1,174 citations

The Generation of Hydrogen Peroxide, Superoxide Radical, and Hydroxyl Radical by 6-Hydroxydopamine, Dialuric Acid, and Related Cytotoxic Agents

1974 • 894 citations

Fatty Liver in the Rat after Prolonged Intake of Ethanol with a Nutritionally Adequate New Liquid Diet

1967 • 604 citations

Acute liver necrosis following overdose of paracetamol.

1966 • 525 citations

Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.

1973 • 500 citations

Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent formation and breakdown of hydrogen peroxide during mixed function oxidation reactions in liver microsomes

1975 • 330 citations

LIVER NECROSIS FROM PARACETAMOL

1966 • 304 citations

Acetaminophen-Induced Hepatic Necrosis V. Correlation of Hepatic Necrosis, Covalent Binding and Glutathione Depletion in Hamsters

1974 • 303 citations

Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo

1979 • 298 citations

Hydroperoxide‐Metabolizing Systems in Rat Liver

1975 • 266 citations

Potentiation of Acetaminophen Hepatotoxicity by Alcohol

1980 • 194 citations

Increased hepatotoxicity of acetaminophen after chronic ethanol consumption in the rat

1981 • 187 citations

Biological oxidation of nitrogen

1979 • 158 citations

Varying effects of sulfhydryl nucleophiles on acetaminophen oxidation and sulfhydryl adduct formation

1979 • 89 citations

3-(glutathion-S-yl)acetaminophen: a biliary metabolite of acetaminophen.

1982 • 89 citations

Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines

1980 • 84 citations

N-hydroxyacetaminophen: A microsomal metabolite of N-hydroxyphenacetin but apparently not of acetaminophen

1979 • 83 citations

Determination of protein in preparations of microsomes

1975 • 79 citations

Functions of intracellular glutathione in hepatic hydroperoxide and drug metabolism and the role of extracellular glutathione

1980 • 74 citations

An in vitro model of liver injury using Paracetamol treatment of liver slices and prevention of injury by some antioxidants

1978 • 62 citations

Lack of evidence for N-hydroxyacetaminophen as a reactive metabolite of acetaminophen in vitro

1980 • 55 citations

Carbon tetrachloride-induced lipid peroxidation: A spin trapping study

1982 • 32 citations

Prevention of paracetamol-induced liver damage in mice with glutathione

1975 • 29 citations

Effect of Model Traumatic Injury on Hepatic Drug-metabolizing Enzymes

1980 • 19 citations