Lipid Peroxidation in Mitochondrial Membrane

CHEMIOSMOTIC COUPLING IN OXIDATIVE AND PHOTOSYNTHETIC PHOSPHORYLATION

1966 • 3,631 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

The cellular production of hydrogen peroxide

1972 • 1,526 citations

The Enzymes of Biological Membranes

1985 • 1,362 citations

The Generation of Superoxide Radical during the Autoxidation of Hemoglobin

1972 • 1,162 citations

Carbon tetrachloride hepatotoxicity.

1967 • 980 citations

Physical and chemical properties of singlet molecular oxygen

1971 • 882 citations

PROGRESS IN REACTION KINETICS

1966 • 881 citations

Molecular Mechanisms of Oxygen Activation

1974 • 879 citations

Mitochondria and calcium ion transport

1970 • 826 citations

Superoxide and Superoxide Dismutases

1978 • 754 citations

Evidence that Peroxidation of Lysosomal Membranes Is Initiated by Hydroxyl Free Radicals Produced during Flavin Enzyme Activity

1973 • 663 citations

A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation

1976 • 606 citations

Molecular Mechanisms of Oxygen Activation

1975 • 588 citations

Vitamin E as the Biological Lipid Antioxidant

1962 • 581 citations

Generation of Superoxide Free Radical during the Autoxidation of Thiols

1974 • 558 citations

Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin

1977 • 545 citations

Respiratory chain linked H₂O₂ production in pigeon heart mitochondria

1971 • 544 citations

Interaction of ascorbic acid and mitochondrial lipides

1959 • 537 citations

Superoxide and superoxide dismutases

1993 • 518 citations

ADP-activated lipid peroxidation coupled to the TPNH oxidase system of microsomes

1963 • 512 citations

Swelling and Lysis of Rat Liver Mitochondria Induced by Ferrous Ions

1963 • 491 citations

A Direct Demonstration of the Catalytic Action of Superoxide Dismutase through the Use of Pulse Radiolysis

1972 • 489 citations

VITAMIN E AND FREE RADICAL PEROXIDATION OF LIPIDS*

1972 • 471 citations

An intracellular GSH-peroxidase with a lipid peroxide substrate

1968 • 450 citations

The production of superoxide anion radicals in the reaction of reduced flavins and flavoproteins with molecular oxygen

1969 • 419 citations

The Univalent Reduction of Oxygen by Reduced Flavins and Quinones

1972 • 418 citations

Acid-base titration across the membrane system of rat-liver mitochondria. Catalysis by uncouplers

1967 • 414 citations

Microviscosity and order in the hydrocarbon region of phospholipid and phospholipid-cholesterol dispersions determined with fluorescent probes

1973 • 361 citations

Intracellular mechanisms for the decomposition of a lipid peroxide. I. Decomposition of a lipid peroxide by metal ions, heme compounds, and nucleophiles

1969 • 353 citations

Effects of level and type of dietary fat on incidence of mammary tumors induced in female sprague‐dawley rats by 7,12‐dimethylbenz(α) anthracene

1971 • 304 citations

Mechanisms of lipid peroxide formation in tissues Role of metals and haematin proteins in the catalysis of the oxidation of unsaturated fatty acids

1965 • 293 citations

The increase of phospholipid bilayer rigidity after lipid peroxidation

1977 • 275 citations

Evidence for the involvement of iron in the ADP-activatedperoxidation of lipids in microsomes and mitochondria

1964 • 267 citations

Properties and Regulation of Glutathione Peroxidase

1970 • 259 citations

Pulse Radiolysis Studies. XIII. Rate Constants for the Reaction of Hydroxyl Radicals with Aromatic Compounds in Aqueous Solutions

1968 • 259 citations

Electron-spin-resonance evidence for enzymic reduction of oxygen to a free radical, the superoxide ion

1969 • 242 citations

Evidence that the superoxide-generating system of human leukocytes is associated with the cell surface.

1977 • 240 citations

Formation of monohydroxy-polyenic fatty acids from lipid peroxides by a glutathione peroxidase

1968 • 234 citations

Direct demonstration of superoxide anion production during the oxidation of reduced flavin and of its catalytic decomposition by erythrocuprein

1969 • 223 citations

The redox potential of the system oxygen—superoxide

1974 • 219 citations

Release of enzymes from lysosomes by irradiation and the relation of lipid peroxide formation to enzyme release

1966 • 213 citations

The Generation of Superoxide Radical during the Autoxidation of Ferredoxins

1971 • 209 citations

Effect of dietary vitamin E on expiration of pentane and ethane by the rat

1977 • 206 citations

Singlet Molecular Oxygen from Superoxide Anion and Sensitized Fluorescence of Organic Molecules

1970 • 206 citations

Cytochrome P-450 as a microsomal peroxidase utilizing a lipid peroxide substrate

1971 • 200 citations

Role of Phospholipids in Transport and Enzymic Reactions

1974 • 199 citations

Paraquat toxicity: proposed mechanism of action involving lipid peroxidation.

1976 • 196 citations

Chemiluminescence and Bioluminescence

1973 • 188 citations

The oxidation of reduced flavin mononucleotide by molecular oxygen

1962 • 185 citations

NADPH-dependent lipid peroxidation catalyzed by purified NADPH-cytochrome c reductase from rat liver microsomes

1972 • 179 citations

PROTECTIVE ACTION OF CAROTENOID PIGMENTS AGAINST PHOTODYNAMIC DAMAGE TO LIPOSOMES*

1973 • 179 citations

Biological protection by superoxide dismutase

1973 • 179 citations

Lipid Peroxidation in Vivo during Vitamin E and Selenium Deficiency in the Rat as Monitored by Ethane Evolution

1977 • 175 citations

Peroxidative and radiation damage to isolated lysosomes

1964 • 167 citations

Evidence for carbon tetrachloride- and ethanol-induced lipid peroxidation in Vivo demonstrated by ethane production in mice and rats

1977 • 160 citations

PHOTOCHEMICAL REACTIONS IN AMINO ACID RESIDUES AND INACTIVATION OF ENZYMES DURING U.V.‐IRRADIATION. A REVIEW

1970 • 154 citations

Hydroxyl radical production involved in lipid peroxidation of rat liver microsomes

1977 • 151 citations

Critical role of lipid peroxidation in carbon tetrachloride-induced loss of aminopyrine demethylase, cytochrome P-450 and glucose 6-phosphatase

1976 • 151 citations

Cholesterol Hydroperoxide Formation in Red Cell Membranes and Photohemolysis in Erythropoietic Protoporphyria

1973 • 151 citations

Substrate-induced chemiluminescence of xanthine oxidase and aldehyde oxidase

1970 • 149 citations

Protection Against Carbon Tetrachloride-Induced Lipid Peroxidation in the Rat by Dietary Vitamin E, Selenium, and Methionine as Measured by Ethane Evolution

1977 • 148 citations

Studies on the Mechanism of Swelling, Lysis, and Distintegration of Isolated Liver Mitochondria Exposed to Mixtures of Oxidized and Reduced Glutathione

1964 • 139 citations

The inhibitory effect of reduced glutathione on the lipid peroxidation of the microsomal fraction and mitochondria

1968 • 129 citations

Oxygen toxicity in the perfused rat liver and lung under hyperbaric conditions

1976 • 127 citations

Spin trapping and its application in the study of lipid peroxidation and free radical production with liver microsomes

1977 • 126 citations

THE PHYSICS, CHEMISTRY, AND BIOLOGY, OF SINGLET MOLECULAR OXYGEN*

1970 • 124 citations

The mechanism of the activity-dependent luminescence of xanthine oxidase

1976 • 122 citations

THE ROLE OF O₂^‐ IN THE CHEMILUMINESCENCE OF LUMINOL*

1973 • 121 citations

The fraction of the lipid in a biological membrane that is in a fluid state: A spin label assay

1972 • 119 citations

Lipid oxidation in biological membranes

1970 • 117 citations

Cholesterol and cell membrane function: A hypothesis concerning the etiology of atherosclerosis

1974 • 117 citations

Effect of Dietary Vitamin E on the Activities of the Glutathione Peroxidase System in Rat Tissues

1973 • 117 citations

Role of ascorbate and cysteine on swelling and lipid peroxidation in rat liver mitochondria

1964 • 115 citations

Reactivity of singlet molecular oxygen with cholesterol in a phospholipid membrane matrix. A model for oxidative damage of membranes

1977 • 112 citations

Analysis of the Torus Surrounding Planar Lipid Bilayer Membranes

1972 • 111 citations

Toxicity of autoxidized squalene and linoleic acid, and of simpler peroxides, in relation to toxicity of radiation

1957 • 104 citations

37. The course of autoxidation reactions in polyisoprenes and allied compounds. Part IV. The isolation and constitution of photochemically-formed methyl oleate peroxide

1943 • 104 citations

Stable lipid peroxidation products in human skin: detection, ultraviolet light-induced increase, pathogenic importance

1976 • 101 citations

Microsomal electron transport

1974 • 101 citations

Interaction of Vitamins A and E

1941 • 90 citations

The effects of ethanol on hepatic lipid peroxidation and on the activities of glutathione reductase and peroxidase

1973 • 85 citations

Effect of Ethylenediaminetetraacetate on Lipide Peroxide Formation and Succinoxidase Inactivation by Ultraviolet Light.

1957 • 85 citations

Mitochondrial Membrane Ghosts Produced by Lipid Peroxidation Induced by Ferrous Ion

1966 • 84 citations

EFFECT OF SINGLET OXYGEN QUENCHERS ON OXIDATIVE DAMAGE TO LIPOSOMES INITIATED BY PHOTOSENSITIZATION OR BY RADIOFREQUENCY DISCHARGE

1974 • 77 citations

The role of NADPH-cytochrome b5 reductase in microsomal lipid peroxidation

1973 • 77 citations

The Effect of Irradiation on Lipid Peroxide Formation in Subcellular Fractions

1967 • 76 citations

The effectiveness of a lipid peroxide in oxidizing protein and non-protein thiols

1968 • 73 citations

The Use of Chemiluminescent Compounds as Possible Indicators of Radical Production during Xanthine Oxidase Action

1960 • 70 citations

Erythrocuprein and singlet oxygen

1972 • 68 citations

Light emission by germinating plants

1954 • 67 citations

Phase Transitions and Heterogeneity in Lipid Bilayers

1973 • 67 citations

Singlet oxygen formation during hemoprotein catalyzed lipid peroxide decomposition

1977 • 65 citations

Determination of absolute rate constants for olefinic oxidations by measurement of photochemical pre- and after-effects. Part I.—At “high” oxygen pressures

1951 • 64 citations

The luminescence of isolated chloroplasts

1951 • 63 citations

Ion Transport by Heart Mitochondria

1968 • 62 citations

Comparison of methods for determining fatty acid oxidation produced by ultraviolet irradiation

1955 • 61 citations

The utilization of iron and its complexes by mammalian mitochondria

1972 • 59 citations

THE ROLE OF POLYUNSATURATED FATTY ACIDS IN DETERMINING VITAMIN E REQUIREMENT*

1972 • 57 citations

Reactions of superoxide anion, catechols, and cytochrome c

1970 • 57 citations

Effects of Phosphate, Arsenate, and other Substances on Swelling and Lipid Peroxide Formation when Mitochondria Are Treated with Oxidized and Reduced Glutathione

1964 • 55 citations

Quantitative measurements of lipide peroxide formation by normal liver mitochondria under various conditions

1960 • 54 citations

A note on the toxicities of methyl oleate peroxide and ethyl linoleate peroxide

1958 • 53 citations

Relation of lipid peroxidation to loss of cations trapped in liposomes

1971 • 53 citations

STUDY OF THE EFFECTS OF ULTRAVIOLET LIGHT ON BIOMEMBRANES—IV. THE EFFECT OF OXYGEN ON UV‐INDUCED HEMOLYSIS AND LIPID PHOTOPEROXIDATION IN RAT ERYTHROCYTES AND LIPOSOMES

1975 • 52 citations

Oxidation of reduced glutathione by subcellular fractions of rat liver

1966 • 49 citations

Lipid oxidation in biological membranes

1970 • 49 citations

The role of superoxide anion radical in the reduction of ferritin iron by xanthine oxidase.

1974 • 43 citations

Inhibition of cell division by ultraviolet irradiated unsaturated fatty acid*1

1957 • 42 citations

Oxygen‐17 Hyperfine Splitting in the Electron Paramagnetic Resonance Spectrum of Enzymically Generated Superoxide

1970 • 42 citations

SOME USEFUL HETEROGENEOUS SYSTEMS FOR PHOTOSENSITIZED GENERATION OF SINGLET OXYGEN

1974 • 41 citations

Heme formation from Fe(II) and porphyrin in the absence of ferrochelatase activity

1973 • 38 citations

Ion Transport by Heart Mitochondria

1971 • 37 citations

Prelytic Damage of Red Cells in Filtrates from Peroxidizing Microsomes

1977 • 36 citations

Binding of Iron and Copper to Bovine Heart Mitochondria

1972 • 36 citations

Effects of Irradiation on Sub-cellular Components

1970 • 34 citations

Formation of lipid peroxides in isolated rat liver microsomes by singlet molecular oxygen

1977 • 31 citations

H₂O₂ Generation in subcellular fractions of leukocytes assayed by cytochrome c peroxidase method

1977 • 30 citations

Acute ferrous sulfate hepatotoxicity in rats. An electron microscopic and biochemical study.

1973 • 29 citations

Binding of Iron and Copper to Bovine Heart Mitochondria

1972 • 27 citations

Evidence that superoxide radicals are involved in the hemolytic mechanism of phenylhydrazine

1977 • 27 citations

Relationship between lipid peroxidation and prostaglandin generation in rabbit tissues

1976 • 27 citations

Observations on the role of vitamin E in the toxicity of oxidized fats

1972 • 26 citations

Influence of pH, Sodium and Calcium Ions on the d.c. Resistance of Black Egg Lecithin–Cholesterol Films

1968 • 25 citations

Stability of asymmetrical phospholipid bilayers

1972 • 22 citations

Effects of cystamine and cysteamine on the peroxidation of lipids and the release of proteins from mitochondria

1966 • 21 citations

The Effect of Irradiation on Sub-cellular Particles–Destruction of Sulphydryl Groups

1967 • 21 citations

Effects of ultraviolet-irradiated methyl linolenate on cell division and respiration in Saccharomyces cerevisiae

1962 • 21 citations

Fe3+ uptake by rat-liver mitochondria

1965 • 20 citations

Studies on the properties of the singlet oxygen-like factor produced during lipid peroxidation

1978 • 19 citations

Lipid peroxidation and its inhibition by tinoridine. I. Lipid peroxidation-induced disintegration of microsomal membrane and cytochrome P-450 in rat liver

1977 • 19 citations

The effect of dietary lipid peroxides, sterols and oxidised sterols on cytochrome P450 and oxidative demethylation in the endoplasmic reticulum

1977 • 19 citations

[Participation of phospholipases in the "repair" of photoreceptor membranes subjected to peroxidation].

1978 • 18 citations

[Interrelationship between structural and functional modifications in the membranes of the sarcoplasmic reticulum following lipid peroxidation].

1977 • 17 citations

Chronic Toxicity of Methyl Linoleate Hydroperoxide for the Rabbit

1966 • 17 citations

Bactericidal Activity of Superoxide Anion and of Hydrogen Peroxide: Investigations Employing Dialuric Acid, a Superoxide-Generating Drug

1975 • 17 citations

Effect of thiols oxidation on lipid peroxidation in rat liver mitochondria

1977 • 16 citations

OXIDATION OF LUMINOL BY THE XANTHINE OXIDASE SYSTEM IN PRESENCE OF CARBONATE ANIONS

1976 • 16 citations

RECENT DEVELOPMENTS IN SINGLET MOLECULAR OXYGEN CHEMISTRY

1976 • 14 citations

Microsomal lipid peroxidation in human pregnant uterus and placenta

1977 • 13 citations

Influence of catalase and superoxide dismutase on side oxidations involving singlet oxygen.

1973 • 13 citations

SHORT COMMUNICATION

1973 • 12 citations

Fatal susceptibility of a free-swimming paramecium to peroxidizing rat liver microsomes

1977 • 12 citations

Binding of iron and copper to bovine heart mitochondria. 3. Role of mitochondrial phospholipids and thiols.

1972 • 11 citations

[Decrease in the electrical stability of lipid membranes following UV-irradiation].

1977 • 11 citations

[Chemiluminescence associated with the formation of lipid peroxides in biological membranes. II. The role of Fe2+ in the development of chain oxidation of lipids and of ultra-weak luminescence].

1969 • 11 citations

[Magnitude of the protein permeability of liposomes following photoperoxidation of lipids].

1977 • 10 citations

Complexation of ferric ions by reduced nicotinamide adenine dinucleotide

1973 • 10 citations

[Chemiluminescence accompanied by the formation of lipid peroxides in biological membranes. I. Luminescence of mitochondria in the presence of Fe2+].

1969 • 10 citations

The Apparent Peroxide Content of Irradiated and Alarmed Mice

1962 • 10 citations

Energy‐dependent accumulation of iron by mitochondria isolated from different tissues and species

1974 • 10 citations

[Kinetic characteristics of the action of tocopherols as antioxidants].

1977 • 9 citations

[Spontaneous and induced autoxidation of phospholipids during conformational rearrangements in outer segment membranes of frog retinal rods].

1975 • 9 citations

Binding of Iron and Copper to Bovine Heart Mitochondria

1972 • 9 citations

[Investigations on ultraweak luminescence in biological systems].

1959 • 9 citations

Investigation of mixed function oxidation by means of chemiluminescence

1969 • 9 citations

[On the problem of the role of the nature of ultraweak luminescence in biological systems].

1962 • 8 citations

[Determination of the mechanism of action of antioxidants in lipid systems from chemiluminescence in the presence of ferrous oxide].

1976 • 8 citations

[Protein-lipid interactions during lipid peroxidation in photoreceptor membranes].

1975 • 7 citations

The distinct enzymic lipid peroxidation systems from liver microsomes in the presence of ADP— or EDTA—iron complexes

1976 • 7 citations

[Chemiluminescence accompanied by the formation of lipid peroxides in biological membranes. VII. Reaction accompanied by luminescence].

1971 • 6 citations

[Chemoluminescence, linked to the formation of lipid peroxides in biological membranes. 8. Reactions of Fe 2+ and lipid peroxides at the rapid light flash stage].

1972 • 6 citations

[Lipid-peroxidation in vivo].

1977 • 6 citations

[Chemiluminescence associated with the formation of lipid peroxides in biological membranes. V. Effect of postmortem processes on the luminescence of homogenates and mitochondria in the presence of ferrous ions].

1970 • 6 citations

[Effect of the products of peroxide oxidation of unsaturated fatty acids on ion transport through bimolecular phospholipid membranes].

1973 • 6 citations

[Kinetics of the interaction of ferrous oxide with oxidized lipids and possibility of chiluminescent determination of hydroperoxides].

1975 • 6 citations

[Distribution of small hydrophobic molecules in membranes. II. Heterogeneity of binding centers on a phospholipid bilayer surface].

1976 • 5 citations

[Role of iron ions in chemiluminescence of lipids].

1968 • 5 citations

[Chemiluminescence associated with the formation of lipid peroxides in biological membranes. X. Peroxide oxidation of lipids in erythrocyte membranes].

1972 • 5 citations

[Use of chemiluminescence activators in the study of chemiluminescence mechanisms during the oxidation of fatty acids and biolipids].

1971 • 4 citations

On the role of free radicals and hydrogen peroxide in some biological oxidations

1969 • 4 citations

[Effect of alpha-tocopherol on the chemiluminescence of mitochondria in the presence of FE2+].

1969 • 3 citations

The effect of far ultraviolet light on mitochondria.

1967 • 3 citations

Stimulative Effects of Chelating Agents, 2, 2’-Bipyridine and 1, 10-Phenanthroline, on Lipid Peroxidation in Rat Liver Microsomes

1977 • 3 citations

[Chemiluminescence connected with lipid peroxidation in biological membranes. XI. Effect of glutathione, cysteine and ascorbic acid].

1974 • 2 citations

[Chemiluminescence connected with the formation of lipid peroxides in biological membranes. IV. Role of the change of iron valency in these processes].

1970 • 2 citations

[Chemoluminescence linked to the formation of lipid peroxides in biological membranes. IX. Luminescence in the presence of luminol].

1972 • 1 citations

[Possible role of free radicals in the transformations and mechanism of physiological action of vitamin D].

1976 • 1 citations

[Chemiluminescence accompanying the formation of lipid peroxides in microsomes].

1971 • 1 citations

[Oxidation and NADPH-dependent reduction of intramitochondrial glutathione].

1973 • 1 citations

[Chemiluminescence accompanying lipid peroxidation in biological membranes. XII. Effect of mitochondrial state on chemiluminescence kinetics. Iron ion transport through mitochondrial membranes].

1974 • 1 citations