Toxicity of 1,2-dibromoethane in isolated hepatocytes: Role of lipid peroxidation

Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent

1968 • 7,671 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

1980 • 1,094 citations

Mechanistic aspects of enhanced lipid peroxidation following glutathione depletion in vivo

1981 • 276 citations

Glutathione Depletion in Isolated Hepatocytes: Its Relation to Lipid Peroxidation and Cell Damage

1979 • 168 citations

The role of glutathione conjugation in the mutagenicity of 1,2-dibromoethane

1980 • 159 citations

The role of methionine in glutathione biosynthesis by isolated hepatocytes

1977 • 159 citations

Maintenance of glutathione content is isolated hepatocyctes

1978 • 158 citations

Mechanisms of cell injury in the killing of cultured hepatocytes by bromobenzene.

1982 • 135 citations

Studies on fatty liver with isolated hepatocytes

1979 • 126 citations

Biosynthesis and regulation of glutathione:Toxicological implications

1980 • 123 citations

Macromolecular binding and metabolism of the carcinogen 1,2-dibromoethane.

1978 • 114 citations

Paracetamol-stimulated lipid peroxidation in isolated rat and mouse hepatocytes

1983 • 91 citations

The relation between the structure of vicinal dihalogen compounds and their mutagenic activation via conjugation to glutathione

1981 • 74 citations

The role of lipid peroxidation in the toxicity of foreign compounds to liver cells

1983 • 71 citations

Response of isolated hepatocytes to organic and inorganic cytotoxins

1983 • 66 citations

The metabolic formation of N-acetyl-S-2-hydroxyethyl-L-cysteine from tetradeutero-1, 2-dibromoethane. Relative importance of oxidation and glutathione conjugation in vivo

1981 • 65 citations

The Metabolism of Ethylene Dibromide in the Rat I. Identification of Detoxification Products in Urine

1966 • 51 citations

The bioactivation of 1,2-dibromoethane in rat hepatocytes: covalent binding to nucleic acids

1982 • 48 citations

Depletion by 1,2-dibromoethane, 1,2-dibromo-3-chloropropane, tris(2,3-dibromopropyl)phosphate,and hexachloro-1,3-butadiene of reduced non-protein sulfhydryl groups in target and non-target organs

1981 • 47 citations

Chloroform-induced glutathione depletion and toxicity in freshly isolated hepatocytes

1980 • 42 citations

Influence of cysteine upon the glutathione status of isolated rat hepatocytes

1981 • 41 citations

Metabolic activation of 1,2-dibromoethane by glutathione transferase and by microsomal mixed function oxidase: further evidence for formation of two reactive metabolites.

1981 • 39 citations

Metabolic activation of 1,2‐dibromoethane to a free radical intermediate by rat liver microsomes and isolated hepatocytes

1983 • 30 citations

The influence of disulfiram and other inhibitors of oxidative metabolism on the formation of 2-hydroxyethyl-mercapturic acid from 1,2-dibromoethane by the rat

1981 • 27 citations

Comparison of ethylene dibromide and carbon tetrachloride toxicity in rats and chicks: Blood and liver levels; lipid peroxidation

1972 • 25 citations

Pathological changes in ethylene dibromide poisoning.

1960 • 21 citations

Enzymatic impairment induced by biological aldehydes in intact rat liver cells.

1982 • 17 citations

Differences in liver morphology between rats and chicks treated with ethylene dibromide

1976 • 16 citations

Modulation of the mitotic action of ethylene dibromide

1980 • 11 citations