High Affinity Very Late Antigen-4 Subsets Expressed on T Cells Are Mandatory for Spontaneous Adhesion Strengthening But Not for Rolling on VCAM-1 in Shear Flow

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

1991 • 2,195 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

α4 integrins mediate lymphocyte attachment and rolling under physiologic flow

1995 • 1,018 citations

The integrin VLA-4 supports tethering and rolling in flow on VCAM-1.

1995 • 716 citations

P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin.

1995 • 712 citations

Integrin cytoplasmic domains mediate inside-out signal transduction

1994 • 682 citations

Regulated expression and binding of three VLA (β1) integrin receptors on T cells

1990 • 634 citations

A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.

1993 • 523 citations

Distinct roles of L-selectin and integrins α4β7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: The multistep model confirmed and refined

1995 • 520 citations

Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway

1997 • 501 citations

Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins

1996 • 494 citations

Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines.

1984 • 424 citations

Integrin Activation by R-ras

1996 • 414 citations

The pathophysiologic role of alpha 4 integrins in vivo.

1994 • 380 citations

A central role for microvillous receptor presentation in leukocyte adhesion under flow

1995 • 380 citations

Identification of two distinct regions of the type III connecting segment of human plasma fibronectin that promote cell type-specific adhesion.

1987 • 350 citations

Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes.

1996 • 343 citations

Characterization of the cell surface heterodimer VLA-4 and related peptides.

1987 • 340 citations

The human peripheral lymph node vascular addressin is a ligand for LECAM-1, the peripheral lymph node homing receptor.

1991 • 307 citations

Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153

1997 • 302 citations

Monoclonal Antibody 9EG7 Defines a Novel β1 Integrin Epitope Induced by Soluble Ligand and Manganese, but Inhibited by Calcium

1995 • 281 citations

Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1.

1993 • 266 citations

Biology of chemokine and classical chemoattractant receptors: differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells.

1996 • 265 citations

T cell adhesion to intercellular adhesion molecule-1 (ICAM-1) is controlled by cell spreading and the activation of integrin LFA-1.

1996 • 249 citations

Costimulation of T Cell Activation by Integrin-associated Protein (CD47) Is an Adhesion-dependent, CD28-independent Signaling Pathway

1997 • 236 citations

VLA‐3: A novel polypeptide association within the VLA molecular complex: cell distribution and biochemical characterization

1986 • 214 citations

Influence of receptor lateral mobility on adhesion strengthening between membranes containing LFA-3 and CD2.

1991 • 213 citations

Direct evidence for two affinity states for lymphocyte function-associated antigen 1 on activated T cells.

1993 • 195 citations

Differential regulation of beta 1 and beta 2 integrin avidity by chemoattractants in eosinophils.

1996 • 194 citations

The C–C Chemokine MCP-1 Differentially Modulates the Avidity of β1 and β2 Integrins on T Lymphocytes

1996 • 193 citations

Mutational Evidence for Control of Cell Adhesion Through Integrin Diffusion/Clustering, Independent of Ligand Binding

1997 • 179 citations

A two-step adhesion cascade for T cell/endothelial cell interactions under flow conditions.

1994 • 168 citations

L- and P-selectins, but not CD49d (VLA-4) integrins, mediate monocyte initial attachment to TNF-alpha-activated vascular endothelium under flow in vitro.

1996 • 157 citations

Increases in soluble VCAM‐1 correlate with a decrease in MRI lesions in multiple sclerosis treated with interferon β‐1b

1997 • 155 citations

Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: two mechanisms with divergent biological consequences.

1994 • 149 citations

The alpha 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo.

1996 • 148 citations

α4β1Integrin-dependent Cell Adhesion Is Regulated by a Low Affinity Receptor Pool That Is Conformationally Responsive to Ligand

1995 • 147 citations

Leukocyte integrins

1995 • 132 citations

T cell receptor-dependent, antigen-specific stimulation of a murine T cell clone induces a transient, VLA protein-mediated binding to extracellular matrix.

1991 • 125 citations

P-selectin, L-selectin, and alpha 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions.

1997 • 125 citations

Rolling and transient tethering of leukocytes on antibodies reveal specializations of selectins

1997 • 116 citations

The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction.

1995 • 115 citations

Ligation of L-selectin on T lymphocytes activates beta1 integrins and promotes adhesion to fibronectin.

1997 • 107 citations

Specialized functional properties of the integrin alpha 4 cytoplasmic domain.

1995 • 103 citations

Vascular Cell Adhesion Molecule (VCAM)-Ig Fusion Protein Defines Distinct Affinity States of the Very Late Antigen-4 (VLA-4) Receptor

1995 • 98 citations

T cell receptor- and beta 1 integrin-mediated signals synergize to induce tyrosine phosphorylation of focal adhesion kinase (pp125FAK) in human T cells.

1995 • 92 citations

Presentation of Integrins on Leukocyte Microvilli: A Role for the Extracellular Domain in Determining Membrane Localization

1997 • 87 citations

A differential role for cell shape in neutrophil tethering and rolling on endothelial selectins under flow.

1996 • 82 citations

Expression and functional characterization of a soluble form of vascular cell adhesion molecule 1

1991 • 81 citations

Calcium-dependent Signaling Pathways in T Cells

1997 • 68 citations

Upregulation of Fas Ligand by Simian Immunodeficiency Virus—A nef-arious Mechanism of Immune Evasion?

1997 • 60 citations

Endothelial P-selectin and VCAM-1 each can function as primary adhesive mechanisms for T cells under conditions of flow

1997 • 55 citations

Association between receptor density, cellular activation, and transformation of adhesive behavior of flowing lymphocytes binding to VCAM‐1

1997 • 46 citations

Predominant role of alpha 4-integrins for distinct steps of lymphoma metastasis.

1996 • 44 citations

Integrin α4 cysteines 278 and 717 modulate VLA-4 ligand binding and also contribute to α4/180 formation

1996 • 43 citations

Integrin-mediated intracellular Ca2+ signaling in Jurkat T lymphocytes.

1997 • 35 citations

Isolation and characterization of cell lines with genetically distinct mutations downstream of protein kinase C that result in defective activation-dependent regulation of T cell integrin function.

1996 • 28 citations

β1-integrins dominate cell traffic of leukemic cells in human bone-marrow stroma

1996 • 19 citations