Breaking the Integrin Hinge

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation.

1985 • 968 citations

Integrin cytoplasmic domains mediate inside-out signal transduction

1994 • 682 citations

Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information

1992 • 532 citations

Focal adhesion kinase and associated proteins

1994 • 525 citations

Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling

1993 • 447 citations

A β ₃ Integrin Mutation Abolishes Ligand Binding and Alters Divalent Cation-Dependent Conformation

1990 • 418 citations

Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.

1991 • 367 citations

Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix

1995 • 349 citations

Modulation of the Affinity of Integrin α _IIb β ₃ (GPIIb-IIIa) by the Cytoplasmic Domain of α _IIb

1991 • 322 citations

Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor.

1990 • 285 citations

Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex

1991 • 270 citations

The Conserved Membrane-proximal Region of an Integrin Cytoplasmic Domain Specifies Ligand Binding Affinity

1995 • 202 citations

The inner world of cell adhesion: integrin cytoplasmic domains

1994 • 193 citations

Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK

1993 • 192 citations

Low molecular weight, non-peptide fibrinogen receptor antagonists

1992 • 190 citations

“Inside-out” signal transduction inhibited by isolated integrin cytoplasmic domains

1994 • 177 citations

The alpha 5 beta 1 integrin fibronectin receptor, but not the alpha 5 cytoplasmic domain, functions in an early and essential step in fibronectin matrix assembly.

1993 • 160 citations

Assembly of extracellular matrix

1992 • 159 citations

A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated.

1994 • 129 citations

Use of polymerase chain reaction catalyzed by Taq DNA polymerase for site-specific mutagenesis

1989 • 127 citations

Activating and Inactivating Mutations in N- and C-terminal i3 Loop Junctions of Muscarinic Acetylcholine Hm1 Receptors

1995 • 94 citations

Regulation of the avidity of integrin alpha 4 beta 7 by the beta 7 cytoplasmic domain.

1994 • 81 citations

Monoclonal antibodies to distinctive epitopes on the α and β subunits of the fibronectin receptor

1988 • 54 citations

Assembly and function of integrin receptors is dependent on opposing alpha and beta cytoplasmic domains.

1995 • 41 citations

Ligand occupancy mimicked by single residue substitutions in a receptor: transmembrane signaling induced by mutation.

1992 • 36 citations