Focal adhesion kinase regulates β1 integrin-dependent T cell migration through an HEF1 effector pathway

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration

1999 • 682 citations

CAS/Crk Coupling Serves as a “Molecular Switch” for Induction of Cell Migration

1998 • 668 citations

Leukocyte polarization in cell migration and immune interactions

1999 • 622 citations

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.

1995 • 620 citations

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

1996 • 595 citations

Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation.

1996 • 514 citations

Integrin signalling and tyrosine phosphorylation: just the FAKs?

1998 • 502 citations

Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell Migration

1998 • 501 citations

Signaling through focal adhesion kinase

1997 • 468 citations

Fibronectin-Stimulated Signaling from a Focal Adhesion Kinase–c-Src Complex: Involvement of the Grb2, p130^cas, and Nck Adaptor Proteins

1997 • 432 citations

Induction of p130^cas Signaling Complex Formation upon Integrin-Mediated Cell Adhesion: a Role for Src Family Kinases

1996 • 422 citations

Induced Focal Adhesion Kinase (FAK) Expression in FAK-Null Cells Enhances Cell Spreading and Migration Requiring Both Auto- and Activation Loop Phosphorylation Sites and Inhibits Adhesion-Dependent Tyrosine Phosphorylation of Pyk2

1999 • 395 citations

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

1998 • 339 citations

Role of focal adhesion kinase in integrin signaling

1997 • 331 citations

Requirement of Phosphatidylinositol 3-Kinase in Focal Adhesion Kinase-promoted Cell Migration

1999 • 276 citations

Human Enhancer of Filamentation 1, a Novel p130^cas-Like Docking Protein, Associates with Focal Adhesion Kinase and Induces Pseudohyphal Growth in Saccharomyces cerevisiae

1996 • 233 citations

Association of Focal Adhesion Kinase with Grb7 and Its Role in Cell Migration

1999 • 224 citations

Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes.

1996 • 165 citations

Tyrosine Phosphorylation of Crk-associated Substrates by Focal Adhesion Kinase

1997 • 155 citations

RANTES induces tyrosine kinase activity of stably complexed p125FAK and ZAP-70 in human T cells.

1996 • 152 citations

Similarities and Differences in RANTES- and (AOP)-RANTES–triggered Signals: Implications for Chemotaxis

1999 • 117 citations

T cell receptor- and beta 1 integrin-mediated signals synergize to induce tyrosine phosphorylation of focal adhesion kinase (pp125FAK) in human T cells.

1995 • 92 citations

Human T and B Lymphocytes Express a Structurally Conserved Focal Adhesion Kinase, pp125^FAK

1993 • 91 citations

Tyrosine phosphorylation of Crk-associated substrate lymphocyte-type is a critical element in TCR- and beta 1 integrin-induced T lymphocyte migration.

1999 • 50 citations

Integrin‐mediated signal transduction in cells lacking focal adhesion kinase p125^FAK

1998 • 40 citations

Pyk2 is differentially regulated by β1 integrin- and CD28-mediated co-stimulation in human CD4+ T lymphocytes

1998 • 39 citations