Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1995 • 1,407 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Regulation of protein kinase C

1997 • 919 citations

Phosphorylation and Activation of p70 ^s6k by PDK1

1998 • 835 citations

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1997 • 740 citations

Cloning and expression of multiple protein kinase C cDNAs

1986 • 683 citations

Regulation of protein kinase C ζ by PI 3-kinase and PDK-1

1998 • 612 citations

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1998 • 579 citations

Protein kinase C is regulated in vivo by three functionally distinct phosphorylations

1995 • 472 citations

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

1998 • 365 citations

Three protein kinase structures define a common motif

1994 • 364 citations

cAMP-dependent Protein Kinase

1989 • 274 citations

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

1998 • 230 citations

Phosphorylation of Protein Kinase C-α on Serine 657 Controls the Accumulation of Active Enzyme and Contributes to Its Phosphatase-resistant State

1997 • 194 citations

Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol.

1992 • 180 citations

In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation.

1994 • 159 citations

Requirement for negative charge on “activation loop” of protein kinase C.

1994 • 153 citations

Phosphorylation at Conserved Carboxyl-terminal Hydrophobic Motif Regulates the Catalytic and Regulatory Domains of Protein Kinase C

1997 • 151 citations

Autophosphorylation of Protein Kinase C at Three Separated Regions of Its Primary Sequence

1990 • 151 citations

Intrapeptide regulation of protein kinase C.

1994 • 139 citations

cAMP-Dependent Protein Kinase

2010 • 130 citations

Threonine-497 is a critical site for permissive activation of protein kinase Cα

1994 • 129 citations

Activity of the MAP kinase ERK2 is controlled by a flexible surface loop

1995 • 123 citations

The direct measurement of protein kinase C (PKC) activity in isolated membranes using a selective peptide substrate

1991 • 110 citations

Determination of in Vivo Phosphorylation Sites in Protein Kinase C

1995 • 102 citations

Identification of the phosphorylated region responsible for the permissive activation of protein kinase C

1993 • 88 citations

Protein kinase C autophosphorylates by an intrapeptide reaction.

1987 • 83 citations

Protected‐Site Phosphorylation of Protein Kinase C in Hippocampal Long‐Term Potentiation

1998 • 57 citations