Developmental Regulation of Expression and Activity of Multiple Forms of the Drosophila RAC Protein Kinase

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Antibodies, a laboratory manual

1989 • 12,929 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

1989 • 2,555 citations

Progressive sequence alignment as a prerequisitetto correct phylogenetic trees

1987 • 1,899 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Comparison of the consensus sequence flanking translational start sites inDrosophilaand vertebrates

1987 • 966 citations

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

1987 • 949 citations

A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region

1991 • 900 citations

Immunological method for mapping genes on Drosophila polytene chromosomes.

1982 • 772 citations

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

1984 • 671 citations

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.

1991 • 537 citations

Characterization of sgk, a Novel Member of the Serine/Threonine Protein Kinase Gene Family Which Is Transcriptionally Induced by Glucocorticoids and Serum

1993 • 537 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

Identification of an AUUUA-Specific Messenger RNA Binding Protein

1989 • 515 citations

Translational and transcriptional control elements in the untranslated leader of the heat-shock gene hsp22

1986 • 455 citations

A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin.

1990 • 434 citations

Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1

1991 • 421 citations

opa: A novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster

1985 • 404 citations

Predicted nucleotide-binding properties of p21 protein and its cancer-associated variant

1983 • 390 citations

A survey of expressed genes in Caenorhabditis elegans

1992 • 355 citations

PH domain: the first anniversary

1994 • 318 citations

[1] Protein kinase classification

1991 • 317 citations

The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG.

1991 • 303 citations

The product of the mei3+ gene, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast.

1987 • 257 citations

pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homology to the vertebrate transcription factor GATA-1

1993 • 222 citations

A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila

1993 • 217 citations

Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis.

1987 • 213 citations

pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo

1993 • 210 citations

Amino acid sequence of the catalytic subunit of bovine type II adenosine cyclic 3',5'-phosphate-dependent protein kinase

1983 • 185 citations

Isolation and characterization of Drosophila cAMP-dependent protein kinase genes.

1988 • 184 citations

Molecular cloning of a second form of rac protein kinase.

1991 • 182 citations

Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex.

1992 • 181 citations

Requirement of the Drosophila raf homologue for torso function

1989 • 181 citations

Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily.

1990 • 179 citations

Isolation and characterization of two new Drosophila protein kinase C genes, including one specifically expressed in photoreceptor cells

1989 • 167 citations

Molecular cloning of cDNAs encoding two isoforms of the catalytic subunit of protein phosphatase 2A

1987 • 165 citations

Raf-1: A kinase currently without a cause but not lacking in effects

1991 • 155 citations

Genetic investigation of cAMP-dependent protein kinase function in Drosophila development.

1993 • 155 citations

An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2+ subfamily.

1990 • 154 citations

Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex.

1994 • 153 citations

A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila

1990 • 151 citations

Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene.

1987 • 141 citations

Proliferation of both somatic and germ cells is affected in the Drosophila mutants of raf proto-oncogene.

1988 • 131 citations

P-element-mediated enhancer detection applied to the study of oogenesis in Drosophila*

1989 • 131 citations

Signal transduction and the fate of the R7 photoreceptor in Drosophila

1991 • 128 citations

The Drosophila Stubble-stubbloid gene encodes an apparent transmembrane serine protease required for epithelial morphogenesis.

1993 • 121 citations

Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase.

1992 • 115 citations

The Doa locus encodes a member of a new protein kinase family and is essential for eye and embryonic development in Drosophila melanogaster.

1994 • 111 citations

Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase

1993 • 105 citations

The torso receptor protein-tyrosine kinase signaling pathway: An endless story

1993 • 101 citations

Isolation of Drosophila genes encoding G protein-coupled receptor kinases.

1991 • 100 citations

A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster

1993 • 96 citations

The Drosophila couch potato protein is expressed in nuclei of peripheral neuronal precursors and shows homology to RNA-binding proteins.

1992 • 94 citations

The Drosophila erect wing Gene, Which Is Important for both Neuronal and Muscle Development, Encodes a Protein Which Is similar to the Sea Urchin P3A2 DNA Binding Protein

1993 • 90 citations

Pleckstrin homology (PH) domains in signal transducton

1994 • 77 citations

PH domains and phospholipases — a meaningful relationship?

1994 • 72 citations

Functional significance of a family of protein kinases encoded at the shaggy locus in Drosophila.

1993 • 70 citations

Drosophila choline acetyltransferase uses a non-AUG initiation codon and full length RNA is inefficiently translated.

1990 • 67 citations

Molecular characterization and expression of the Drosophila Ca2+/calmodulin-dependent protein kinase II gene. Identification of four forms of the enzyme generated from a single gene by alternative splicing.

1993 • 55 citations

The parainfluenza virus type 1 P/C gene uses a very efficient GUG codon to start its C' protein

1992 • 53 citations

The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1.

1994 • 51 citations

Signal transduction and the fate of the R7 photoreceptor in drosophila

1991 • 51 citations

Selection of CUG and AUG initiator codons for Drosophila E74A translation depends on downstream sequences.

1993 • 28 citations

Serine/threonine protein kinases in Drosophila

1990 • 16 citations

Translation Initiation from Non-AUG Codons in COS1 Cells Is mRNA Species Dependent

1994 • 9 citations

Identification of a Novel Drosophila Gene Encoding a Cdc2-Related Protein Kinase

1994 • 4 citations