Guanosine 5′-O-(3-Thiotriphosphate) (GTPγS) Stimulation of GLUT4 Translocation is Tyrosine Kinase-dependent

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

The insulin signaling system.

1994 • 1,733 citations

PI3K: Downstream AKTion Blocks Apoptosis

1997 • 1,693 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Insulin Action and the Insulin Signaling Network*

1995 • 823 citations

Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence

1989 • 815 citations

A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits

1994 • 597 citations

A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain

1997 • 481 citations

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

1992 • 471 citations

Translocation of the glucose transporter GLUT4 in cardiac myocytes of the rat.

1991 • 398 citations

Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily

1995 • 385 citations

Identification and Characterization of a Novel Related Adhesion Focal Tyrosine Kinase (RAFTK) from Megakaryocytes and Brain

1995 • 365 citations

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

1994 • 362 citations

Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase.

1995 • 358 citations

Physiological Role of Akt in Insulin-Stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells

1997 • 358 citations

The Effects of Wortmannin on Rat Skeletal Muscle

1995 • 320 citations

Translocation of the glucose transporter (GLUT4) to the cell surface in permeabilized 3T3-L1 adipocytes: effects of ATP insulin, and GTP gamma S and localization of GLUT4 to clathrin lattices

1992 • 307 citations

Stimulation of glucose transport in skeletal muscle by hypoxia

1991 • 299 citations

GABAB Receptor Inhibition of P-type Ca2+ Channels in Central Neurons

1993 • 274 citations

Determinants of the G protein-dependent opioid modulation of neuronal calcium channels.

1996 • 272 citations

Calcium‐dependent currents in cultured rat dorsal root ganglion neurones are inhibited by an adenosine analogue.

1986 • 256 citations

Activation of a Novel Calcium-dependent Protein-tyrosine Kinase

1996 • 256 citations

Potential Role of Protein Kinase B in Glucose Transporter 4 Translocation in Adipocytes*

1997 • 252 citations

Regulation of Protein Kinase B and Glycogen Synthase Kinase-3 by Insulin and β-Adrenergic Agonists in Rat Epididymal Fat Cells

1997 • 241 citations

Syntaxin 4, VAMP2, and/or VAMP3/Cellubrevin Are Functional Target Membrane and Vesicle SNAP Receptors for Insulin-Stimulated GLUT4 Translocation in Adipocytes

1997 • 236 citations

Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase.

1996 • 194 citations

Direct demonstration of insulin-induced GLUT4 translocation to the surface of intact cells by insertion of a c-myc epitope into an exofacial GLUT4 domain

1993 • 156 citations

Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells.

1995 • 146 citations

Osmotic Shock Stimulates GLUT4 Translocation in 3T3L1 Adipocytes by a Novel Tyrosine Kinase Pathway

1997 • 143 citations

Opioid receptors modulate diverse types of calcium channels in the nucleus tractus solitarius of the rat

1994 • 140 citations

Insulin and nonhydrolyzable GTP analogs induce translocation of GLUT 4 to the plasma membrane in alpha-toxin-permeabilized rat adipose cells

1991 • 139 citations

Molecular Actions of Insulin on Glucose Transport

1995 • 98 citations

The relationship between the transport of glucose and cations across cell membranes in isolated tissues. IX. The role of cellular calcium in the activation of the glucose transport system in rat soleus muscle

1975 • 94 citations

Effects of Wortmannin on Increased Glucose Transport by Insulin and Norepinephrine in Primary Culture of Brown Adipocytes

1994 • 50 citations

Effect of the Activation of Phosphatidylinositol 3-Kinase by a Thiophosphotyrosine Peptide on Glucose Transport in 3T3-L1 Adipocytes

1995 • 49 citations

Gq-coupled Receptors Transmit the Signal for GLUT4 Translocation via an Insulin-independent Pathway

1996 • 39 citations

PI 3-Kinase Activation Is Required for Insulin Stimulation of Glucose Transport into L6 Myotubes

1994 • 37 citations

Nitrate Ions: Potentiation of Increased Permeability to Sugar Associated with Muscle Contraction

1967 • 36 citations

Insulin and noradrenaline independently stimulate the translocation of glucose transporters from intracellular stores to the plasma membrane in mouse brown adipocytes

1992 • 36 citations

Insulin and Epidermal Growth Factor Stimulate a Conformational Change in Rap1 and Dissociation of the CrkII-C3G Complex

1997 • 33 citations

Regulation of glucose carrier activity by AlCl3 and phospholipase C in fat-cells

1988 • 32 citations

Signals mediating stimulation of cardiomyocyte glucose transport by the alpha-adrenergic agonist phenylephrine

1996 • 30 citations

Insulin-Stimulated Phosphatidylinositol 3-Kinase Activity and 2-Deoxy-D-Glucose Uptake in Rat Skeletal Muscles

1995 • 26 citations

Roles of insulin, guanosine 5′-[γ-thio]triphosphate and phorbol 12-myristate 13-acetate in signalling pathways of GLUT4 translocation

1996 • 25 citations

Is stimulation of class-I phosphatidylinositol 3-kinase activity by insulin sufficient to activate pathways involved in glucose metabolism

1997 • 17 citations