The protein kinase C and protein kinase C related gene families

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

1995 • 680 citations

PKCu is a novel, atypical member of the protein kinase C family.

1994 • 519 citations

A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.

1993 • 486 citations

Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence.

1989 • 439 citations

Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain.

1994 • 406 citations

Three protein kinase structures define a common motif

1994 • 364 citations

Identification and Characterization of Zinc Binding Sites in Protein Kinase C

1991 • 193 citations

Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol.

1992 • 180 citations

Expression and Characterization of PKD, a Phorbol Ester and Diacylglycerol-stimulated Serine Protein Kinase

1995 • 170 citations

In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation.

1994 • 159 citations

Requirement for negative charge on “activation loop” of protein kinase C.

1994 • 153 citations

Cloning and Expression Patterns of two Members of A Novel Protein‐kinase‐C‐related Kinase Family

1995 • 146 citations

Intrapeptide regulation of protein kinase C.

1994 • 139 citations

Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor

1990 • 136 citations

Two functionally different domains of rabphilin-3A, Rab3A p25/smg p25A-binding and phospholipid- and Ca(2+)-binding domains.

1993 • 132 citations

Solution structure of a cysteine rich domain of rat protein kinase C

1994 • 131 citations

The regulatory domain of protein kinase C coordinates four atoms of zinc.

1992 • 129 citations

Threonine-497 is a critical site for permissive activation of protein kinase Cα

1994 • 129 citations

Doc2: A Novel Brain Protein Having Two Repeated C2-like Domains

1995 • 124 citations

Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products

1994 • 120 citations

Characterization of Activators and Inhibitors of Protein Kinase Cμ

1995 • 89 citations

Identification of the phosphorylated region responsible for the permissive activation of protein kinase C

1993 • 88 citations

The regulatory region of protein kinase C gamma. Studies of phorbol ester binding to individual and combined functional segments expressed as glutathione S-transferase fusion proteins indicate a complex mechanism of regulation by phospholipids, phorbol esters, and divalent cations.

1994 • 84 citations

Close similarity of baculovirus-expressed n-chimaerin and protein kinase C alpha as phorbol ester receptors.

1994 • 81 citations

Calcium-dependent activation of protein kinase C. The role of the C2 domain in divalent cation selectivity.

1993 • 78 citations

Mutagenesis of the regulatory domain of rat protein kinase C-eta. A molecular basis for restricted histone kinase activity.

1993 • 61 citations

Kinetic evidence that 1,2-diolein inhibits phorbol ester binding to protein kinase C via a competitive mechanism

1985 • 48 citations

Identification of multiple, novel, protein kinase C‐related gene products

1994 • 45 citations

Protein kinase C V₃ domain mutants with differential sensitivities to m‐calpain are not resistant to phorbol‐ester‐induced down‐regulation

1994 • 27 citations

Altered substrate selectivity of PKC‐η pseudosubstrate site mutants

1993 • 26 citations

Identification of the phosphorylated region responsible for the permissive activation of PKC

1993 • 3 citations

Deleted Work

1955 • 0 citations