Type 1/Type 2 Immunity in Infectious Diseases

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Federation Proceedings

2009 • 3,950 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure

1984 • 3,130 citations

A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

1987 • 2,769 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Pneumocystis cariniiPneumonia and Mucosal Candidiasis in Previously Healthy Homosexual Men

1981 • 2,717 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

1998 • 1,574 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Clinical Aspects of Immunology.

1969 • 1,563 citations

Clinical and Experimental Immunology

1966 • 1,544 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

The Journal of Laboratory and Clinical Medicine

2004 • 1,433 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.

1998 • 1,382 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Genotypic and Phenotypic Characterization of HIV-1 Patients with Primary Infection

1993 • 1,258 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.

1993 • 1,084 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

1987 • 966 citations

Plasma norepinephrine in congestive heart failure

1978 • 919 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

An Interleukin-4-Induced Transcription Factor: IL-4 Stat

1994 • 856 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

Regulation of Immunity to Parasites by T Cells and T Cell-Derived Cytokines

1992 • 843 citations

Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor Deficiency

1998 • 837 citations

Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.

1991 • 835 citations

Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients

1998 • 812 citations

Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells

1998 • 809 citations

Effects of Single-Dose Interleukin-12 Exposure on Interleukin-12–Associated Toxicity and Interferon-γ Production

1997 • 788 citations

Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells.

1996 • 788 citations

A Controlled Trial of Interferon Gamma to Prevent Infection in Chronic Granulomatous Disease

1991 • 785 citations

An innate sense of danger

1998 • 752 citations

Experimental Hematology

2003 • 736 citations

Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

1988 • 713 citations

The Th1–Th2 hypothesis of HIV infection: new insights

1994 • 708 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production.

1995 • 676 citations

Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

1995 • 672 citations

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene

1997 • 666 citations

Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10.

1993 • 657 citations

IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells.

1997 • 615 citations

Activation of CD4+ T cells, increased T-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma

1993 • 593 citations

IL-13, IL-4Rα, and Stat6 Are Required for the Expulsion of the Gastrointestinal Nematode Parasite Nippostrongylus brasiliensis

1998 • 582 citations

Interleukin-17 and Interferon-γ Synergize in the Enhancement of Proinflammatory Cytokine Production by Human Keratinocytes

1998 • 565 citations

Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.

1991 • 528 citations

Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance.

1993 • 526 citations

Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia.

1996 • 522 citations

Contribution of CpG motifs to the immunogenicity of DNA vaccines.

1997 • 519 citations

Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide.

1993 • 504 citations

Establishment of Stable, Cell-Mediated Immunity that Makes "Susceptible" Mice Resistant to Leishmania major

1992 • 503 citations

T-Helper 1-Type Immunity to Trophoblast in Women With Recurrent Spontaneous Abortion

1995 • 495 citations

Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease. Crohn's Disease Study Group

1997 • 493 citations

Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.

1996 • 487 citations

Human 60-kDa Heat-Shock Protein: A Danger Signal to the Innate Immune System

1999 • 474 citations

IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-τ

2005 • 463 citations

Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B.

1998 • 459 citations

Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin

1994 • 456 citations

Expression of Interleukin 9 in the Lungs of Transgenic Mice Causes Airway Inflammation, Mast Cell Hyperplasia, and Bronchial Hyperresponsiveness

1998 • 448 citations

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

1995 • 446 citations

Abnormal Clones of T Cells Producing Interleukin-5 in Idiopathic Eosinophilia

1999 • 445 citations

Interleukin 10 production correlates with pathology in human Leishmania donovani infections.

1993 • 445 citations

Induction of immunological paralysis in two zones of dosage

1964 • 439 citations

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.

1996 • 437 citations

Cytokine-mediated regulation of chronic intestinal helminth infection.

1994 • 425 citations

Differential expression of the beta2-adrenergic receptor by Th1 and Th2 clones: implications for cytokine production and B cell help.

1997 • 424 citations

IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity.

1992 • 422 citations

Interleukin-4 Receptor in Moderate Atopic Asthma

1999 • 421 citations

Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: clinical implications.

1996 • 420 citations

Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia

1999 • 417 citations

IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells.

1992 • 417 citations

A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses.

1995 • 415 citations

IL-6 Is Required for the Development of Th1 Cell-Mediated Murine Colitis

2000 • 412 citations

Controlled Trial of Interleukin-2 Infusions in Patients Infected with the Human Immunodeficiency Virus

1996 • 406 citations

Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.

1998 • 405 citations

Restoration of HIV-Specific Cell-Mediated Immune Responses by Interleukin-12 in Vitro

1993 • 397 citations

Interleukin-10 Inhibits Expression of Both Interferon – and Interferon γ– Induced Genes by Suppressing Tyrosine Phosphorylation of STAT1

1999 • 397 citations

Effects of Th2 Cytokines on Chemokine Expression in the Lung: IL-13 Potently Induces Eotaxin Expression by Airway Epithelial Cells

1999 • 397 citations

IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau.

1995 • 395 citations

Surgical stress induces a shift in the type-1/type-2 T-helper cell balance, suggesting down-regulation of cell-mediated and up-regulation of antibody-mediated immunity commensurate to the trauma

1996 • 390 citations

Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen.

1962 • 386 citations

Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells.

1990 • 386 citations

CpG DNA Induces Sustained IL-12 Expression In Vivo and Resistance toListeria monocytogenesChallenge

1998 • 383 citations

A new murine CD4+ T cell subset with an unrestricted cytokine profile.

1989 • 374 citations

Cytokine patterns in the pathogenesis of human leishmaniasis.

1993 • 372 citations

DNA from Bacteria, but Not from Vertebrates, Induces Interferons, Activates Natural Killer Cells and Inhibits Tumor Growth

1992 • 370 citations

Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection.

1993 • 359 citations

Lethal tuberculosis in interleukin-6-deficient mutant mice

1997 • 359 citations

Simultaneous Disruption of Interleukin (IL)-4 and IL-13 Defines Individual Roles in T Helper Cell Type 2–mediated Responses

1999 • 352 citations

Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function.

1990 • 349 citations

Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha.

1995 • 348 citations

A progesterone-dependent immunomodulatory protein alters the Th1Th2 balance

1996 • 347 citations

Lactobacilli and Streptococci Induce Interleukin-12 (IL-12), IL-18, and Gamma Interferon Production in Human Peripheral Blood Mononuclear Cells

1998 • 346 citations

T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions. Correlation with increased IFN-gamma and TNF and reduced IL-10 production by placental cells.

1996 • 345 citations

Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation

1998 • 332 citations

Maternal Th1- and Th2-Type Reactivity to Placental Antigens in Normal Human Pregnancy and Unexplained Recurrent Spontaneous Abortions

1999 • 331 citations

Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway

1996 • 325 citations

Regulation of murine lymphokine production in vivo II. Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells

1990 • 324 citations

Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic.

1990 • 319 citations

Pregnancy impairs resistance of C57BL/6 mice to Leishmania major infection and causes decreased antigen-specific IFN-gamma response and increased production of T helper 2 cytokines.

1996 • 311 citations

Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens.

1994 • 309 citations

Interleukin-12 Is Essential for a Protective Th1 Response in Mice Infected withCryptococcus neoformans

1998 • 303 citations

Human Dendritic Cells Require Exogenous Interleukin-12–Inducing Factors to Direct the Development of Naive T-Helper Cells Toward the Th1 Phenotype

1997 • 302 citations

Interleukin 4 induces synthesis of IgE and IgG4 in human B cells

1989 • 300 citations

Bacterial DNA-Induced NK Cell IFN-γ Production Is Dependent on Macrophage Secretion of IL-12

1997 • 300 citations

Expression of the cytokine RANTES in human rheumatoid synovial fibroblasts. Differential regulation of RANTES and interleukin-8 genes by inflammatory cytokines.

1993 • 296 citations

Lymphocyte blast transformation

1970 • 293 citations

Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness.

1987 • 289 citations

Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level.

1996 • 287 citations

A Critical Role for IL-13 in Resistance to Intestinal Nematode Infection

1998 • 284 citations

Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype.

1994 • 282 citations

IMMUNITY IN INFECTIVE DISEASES

1906 • 282 citations

Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites.

1994 • 281 citations

Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens.

1997 • 278 citations

Dehydroepiandrosterone enhances IL2 production and cytotoxic effector function of human T cells

1991 • 275 citations

Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation.

1997 • 273 citations

IL-4-deficient Balb/c mice resist infection with Leishmania major.

1996 • 273 citations

Regulatory T cells and inflammatory bowel disease

1999 • 270 citations

Development of Th1 and Th2 Populations and the Nature of Immune Responses to Hepatitis B Virus DNA Vaccines Can Be Modulated by Codelivery of Various Cytokine Genes

1998 • 267 citations

Interleukin‐4 and interleukin‐10 inhibit nitric oxide‐dependent macrophage killing of Candida albicans

1993 • 260 citations

Estrogen enhances immunoglobulin production by human PBMCs

1999 • 257 citations

Inhibition of Th1 Immune Response by Glucocorticoids: Dexamethasone Selectively Inhibits IL-12-Induced Stat4 Phosphorylation in T Lymphocytes

2000 • 255 citations

Role of Interleukin-18 (IL-18) in Mycobacterial Infection in IL-18-Gene-Disrupted Mice

1999 • 249 citations

The classification of allergic reactions underlying disease

1963 • 248 citations

Modulation of amplitude and direction ofin vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens

1998 • 241 citations

Differential Th1 and Th2 cell responses in male and female BALB/c mice infected with coxsackievirus group B type 3

1994 • 241 citations

Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements.

1992 • 239 citations

Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines.

1996 • 237 citations

The Primary Binding Subunit of the Human Interleukin-4 Receptor Is Also a Component of the Interleukin-13 Receptor

1995 • 236 citations

Interleukin 9: A candidate gene for asthma

1997 • 236 citations

Th1- and Th2-Type Cytokines Regulate the Expression and Production of Eotaxin and RANTES by Human Lung Fibroblasts

1999 • 235 citations

IL-12 induces the production of IFN-gamma by neonatal human CD4 T cells.

1993 • 232 citations

Chronic mucocutaneous candidiasis

2001 • 231 citations

Role of interleukin 1 in the activation of T lymphocytes.

1988 • 231 citations

IMMUNE RESPONSE TO CHEMICALLY MODIFIED FLAGELLIN

1971 • 230 citations

Interleukin 10 Secretion and Impaired Effector Function of Major Histocompatibility Complex Class II–restricted T Cells Anergized In Vivo

1998 • 225 citations

Restoration of IFN-gamma production and lymphocyte proliferation in visceral leishmaniasis.

1994 • 224 citations

Type 2 Cytokine Gene Activation and Its Relationship to Extent of Disease in Patients with Tuberculosis

2000 • 220 citations

Th1 and Th2 cytokines in mice with invasive aspergillosis

1997 • 216 citations

Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families.

1998 • 215 citations

Loss of lean body and muscle mass correlates with androgen levels in hypogonadal men with acquired immunodeficiency syndrome and wasting.

1996 • 215 citations

CONTROLLED TRIAL OF INTERLEUKIN-2 INFUSIONS IN PATIENTS INFECTED WITH THE HUMAN IMMUNODEFICIENCY VIRUS

1996 • 214 citations

The third function of the thymus

2000 • 213 citations

Activated T helper 1 and T helper 2 cells differentially express the beta-2-adrenergic receptor: a mechanism for selective modulation of T helper 1 cell cytokine production.

1997 • 212 citations

Murine cutaneous leishmaniasis : Susceptibility correlates with differential expansion of helper T-cell subsets

1987 • 212 citations

Body Composition and Endocrine Function in Women with Acquired Immunodeficiency Syndrome Wasting¹

1997 • 206 citations

Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1-associated immunity in murine candidiasis.

1992 • 204 citations

Prostaglandin E2 at priming of naive CD4+ T cells inhibits acquisition of ability to produce IFN-gamma and IL-2, but not IL-4 and IL-5.

1995 • 203 citations

Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10-deficient mice.

1997 • 202 citations

Do Suppressor T Cells Exist?

1988 • 201 citations

Fatal Disseminated Mycobacterium smegmatis Infection in a Child with Inherited Interferon Receptor Deficiency

1997 • 197 citations

IMMUNE RESPONSE TO CHEMICALLY MODIFIED FLAGELLIN

1972 • 196 citations

Stat6 Signaling Promotes Protective Immunity Against Trichinella spiralis Through a Mast Cell- and T Cell-Dependent Mechanism

2000 • 196 citations

The spectrum of human tuberculosis.

1977 • 195 citations

An immunoregulatory role for neutrophils in CD4+ T helper subset selection in mice with candidiasis.

1997 • 194 citations

Macrophages are a significant source of type 1 cytokines during mycobacterial infection

1999 • 194 citations

Neutralization of IL-10 up-regulates nitric oxide production and protects susceptible mice from challenge with Candida albicans.

1994 • 190 citations

Instruction for Cytokine Expression in T Helper Lymphocytes in Relation to Proliferation and Cell Cycle Progression

1999 • 190 citations

Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells.

1997 • 188 citations

The interplay between the duration of TCR and cytokine signaling determines T cell polarization

1999 • 187 citations

Cellular immune responses to the murine nematode parasite Trichuris muris. I. Differential cytokine production during acute or chronic infection.

1991 • 186 citations

Interleukin‐9 is involved in host protective immunity to intestinal nematode infection

1997 • 185 citations

Peptide Dose, Affinity, and Time of Differentiation Can Contribute to the Th1/Th2 Cytokine Balance

1999 • 182 citations

Glucocorticoids Inhibit Bioactive IL-12p70 Production by In Vitro-Generated Human Dendritic Cells Without Affecting Their T Cell Stimulatory Potential

1998 • 181 citations

Interferon‐γ plays a critical role in intestinal immunity against Salmonella typhimurium infection

2000 • 180 citations

Immune responsiveness and lymphokine production in patients with tuberculosis and healthy controls

1994 • 180 citations

Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam.

1995 • 179 citations

Downregulation of T helper type 1 immune response and altered pro-inflammatory and anti-inflammatory T cell cytokine balance following conventional but not laparoscopic surgery11This work was supported by DFG grants Si 208/5-1 and Si 208/5-4 to the clinical research group, “Immunosuppression und Postoperative Sepsis.”

1999 • 179 citations

Circadian Variations in Plasma Levels of Hypophyseal, Adrenocortical and Testicular Hormones in Men Infected with Human Immunodeficiency Virus*

1990 • 179 citations

Human Th1 and Th2 cells: functional properties, mechanisms of regulation, and role in disease.

1994 • 174 citations

Defective monocyte costimulation for IFN-gamma production in familial disseminated Mycobacterium avium complex infection: abnormal IL-12 regulation.

1996 • 174 citations

Human polymorphonuclear leukocytes produce IL-12, TNF-alpha, and the chemokines macrophage-inflammatory protein-1 alpha and -1 beta in response to Toxoplasma gondii antigens.

1999 • 174 citations

Cytokine transcriptional events during helper T cell subset differentiation.

1996 • 174 citations

Cellular immune responses to the murine nematode parasite Trichuris muris. II. Differential induction of TH-cell subsets in resistant versus susceptible mice.

1992 • 173 citations

Interleukin-4-dependent pulmonary eosinophil infiltration in a murine model of asthma.

1994 • 172 citations

Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells.

1988 • 172 citations

Murine cutaneous leishmaniasis: resistance correlates with the capacity to generate interferon-gamma in response to Leishmania antigens in vitro.

1986 • 169 citations

Host protective immunity to Trichinella spiralis in mice: activation of Th cell subsets and lymphokine secretion in mice expressing different response phenotypes.

1991 • 166 citations

TH1 and TH2 cytokine production by peripheral blood mononuclear cells from HIV-infected patients

1994 • 164 citations

Subcutaneous Administration of Interleukin‐2 in Human Immunodeficiency Virus Type 1—Infected Persons

1997 • 164 citations

IL-4-induced STAT6 suppresses IFN-gamma-stimulated STAT1-dependent transcription in mouse macrophages.

1997 • 162 citations

Regulation by corticosteroids of Th1 and Th2 cytokine production in human CD4+ effector T cells generated from CD45RO- and CD45RO+ subsets.

1995 • 159 citations

Long-term itraconazole prophylaxis against Aspergillus infections in thirty-two patients with chronic granulomatous disease

1994 • 159 citations

Stability of T_h1 and T_h2 populations

1995 • 158 citations

Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia inTrichuris muris-infected mice

2000 • 157 citations

Interleukin 10 Treatment of Psoriasis

1999 • 155 citations

In Vivo Modulation of Vaccine-Induced Immune Responses toward a Th1 Phenotype Increases Potency and Vaccine Effectiveness in a Herpes Simplex Virus Type 2 Mouse Model

1999 • 154 citations

The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor beta 2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12.

1998 • 151 citations

Abnormal Regulation of Interferon‐γ, Interleukin‐12, and Tumor Necrosis Factor‐α in Human Interferon‐g Receptor 1 Deficiency

1998 • 150 citations

Interleukin-9 Enhances Resistance to the Intestinal NematodeTrichuris muris

1998 • 149 citations

Comparison of subcutaneous and intravenous interleukin-2 in asymptomatic HIV-1 infection: a randomised controlled trial

1999 • 149 citations

Decreased CD4+ Lymphocyte Activation and Increased Interleukin-4 Production in Peripheral Blood of Rheumatoid Arthritis Patients After Acute Starvation

1999 • 148 citations

Human T cell responses induced by vaccination with Mycobacterium bovis bacillus Calmette-Guérin.

1997 • 147 citations

Single cell analysis of cytokine gene coexpression during CD4+ T-cell phenotype development.

1995 • 146 citations

Tumor Necrosis Factor α Is a Critical Component of Interleukin 13–Mediated Protective T Helper Cell Type 2 Responses during Helminth Infection

1999 • 145 citations

Differential regulation of IL-13 and IL-4 production by human CD8⁺ and CD4⁺ T_h0, T_h1 and T_h2 T cell clones and EBV-transformed B cells

1995 • 145 citations

Heterogeneity of helper/inducer T lymphocytes. III. Responses of IL-2- and IL-4-producing (Th1 and Th2) clones to antigens presented by different accessory cells.

1990 • 144 citations

Induction of phagocyte cytochrome b heavy chain gene expression by interferon gamma.

1988 • 143 citations

Listeria monocytogenes and recurrent mycobacterial infections in a child with complete interferon-γ-receptor (IFNγR1) deficiency

1999 • 142 citations

Three distinct classes of regulatory cytokines control endothelial cell MHC antigen expression. Interactions with immune gamma interferon differentiate the effects of tumor necrosis factor and lymphotoxin from those of leukocyte alpha and fibroblast beta interferons.

1988 • 142 citations

Human Polymorphonuclear Leukocytes Produce IL-12, TNF-α, and the Chemokines Macrophage-Inflammatory Protein-1α and -1β in Response toToxoplasma gondiiAntigens

1999 • 141 citations

Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines.

1991 • 139 citations

Evidence for differential induction of helper T cell subsets during Trichinella spiralis infection.

1989 • 138 citations

Weight loss causes neuroendocrine disturbances: experimental study in healthy starving subjects

1986 • 138 citations

Intraepithelial Infiltration by Mast Cells with Both Connective Tissue-Type and Mucosal-Type Characteristics in Gut, Trachea, and Kidneys of IL-9 Transgenic Mice

1998 • 137 citations

Regulation of T helper cell cytokine expression: functional dichotomy of antigen‐presenting cells

1993 • 136 citations

Body Composition and Endocrine Function in Women with Acquired Immunodeficiency Syndrome Wasting

1997 • 135 citations

A quantitative analysis of antigen-presenting cell function: activated B cells stimulate naive CD4 T cells but are inferior to dendritic cells in providing costimulation.

1994 • 133 citations

Interleukin-4 mediates down regulation of antiviral cytokine expression and cytotoxic T-lymphocyte responses and exacerbates vaccinia virus infection in vivo

1996 • 132 citations

Functional heterogeneity among human inducer T cell clones.

1988 • 131 citations

Induction of Th2 cell differentiation in the primary immune response: dendritic cells isolated from adherent cell culture treated with IL-10 prime naive CD4+ T cells to secrete IL-4

1998 • 130 citations

IFN-gamma-mediated control of Coxiella burnetii survival in monocytes: the role of cell apoptosis and TNF.

1999 • 129 citations

Altered Helper T Lymphocyte Function Associated with Chronic Hepatitis B Virus Infection and its Role in Response to Therapeutic Vaccination in Humans

1999 • 128 citations

Interleukin-10 inhibits neutrophil phagocytic and bactericidal activity

1996 • 126 citations

In vitro maturation of human neonatal CD4 T lymphocytes. II. Cytokines present at priming modulate the development of lymphokine production.

1994 • 126 citations

Induction of IFN-γ-producing CD4+ natural killer T cells byMycobacterium bovis bacillus Calmette Guérin

1999 • 126 citations

Heat-KilledListeria monocytogenesas an Adjuvant Converts Established Murine Th2-Dominated Immune Responses into Th1-Dominated Responses

1998 • 125 citations

T helper 1- and T helper 2-type cytokine imbalance in pregnant women with pre-eclampsia

1999 • 124 citations

Hypercortisolemia increases plasma interleukin-10 concentrations during human endotoxemia--a clinical research center study.

1996 • 124 citations

IL-13 induces proliferation, Ig isotype switching, and Ig synthesis by immature human fetal B cells.

1994 • 121 citations

In Vivo Interferon- Therapy Augments the In Vitro Ability of Chronic Granulomatous Disease Neutrophils to Damage Aspergillus Hyphae

1991 • 121 citations

Chronic Pseudomonas aeruginosa lung infection is more severe in Th₂ responding BALB/c mice compared to Th₁ responding C₃H/HeN mice

1997 • 120 citations

Loss of lean body and muscle mass correlates with androgen levels in hypogonadal men with acquired immunodeficiency syndrome and wasting

1996 • 120 citations

Protection against Respiratory Syncytial Virus Infection by DNA Immunization

1998 • 119 citations

Relative efficiency of microglia, astrocytes, dendritic cells and B cells in naive CD4+ T cell priming and Th1/Th2 cell restimulation

1999 • 118 citations

Interleukin-10 gene knock-out mice: a model of chronic inflammation

1995 • 118 citations

Cytosolic free calcium increases before and oscillates during frustrated phagocytosis in macrophages.

1987 • 117 citations

Nippostrongylus brasiliensis:Cytokine Responses and Nematode Expulsion in Normal and IL-4-Deficient Mice

1996 • 116 citations

Interleukin-9 and its receptor: involvement in mast cell differentiation and T cell oncogenesis

1995 • 116 citations

Antigen presentation in brain: MHC induction on brain endothelium and astrocytes compared.

1987 • 115 citations

The Chemokine Repertoire of Human Dermal Microvascular Endothelial Cells and Its Regulation by Inflammatory Cytokines

1997 • 115 citations

Catecholamines trigger IL-10 release in acute systemic stress reaction by direct stimulation of its promoter/enhancer activity in monocytic cells

2000 • 114 citations

A phase I/II study of recombinant human interleukin-12 in patients with chronic hepatitis B

2000 • 113 citations

Dendritic Cell-Derived IL-12 Promotes B Cell Induction of Th2 Differentiation: A Feedback Regulation of Th1 Development

1999 • 112 citations

Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription.

1991 • 112 citations

Parasite dose determines the Th1/Th2 nature of the response toLeishmania major independently of infection route and strain of host or parasite

1998 • 112 citations

The IL-4 Rapidly Produced in BALB/c Mice After Infection with Leishmania major Down-Regulates IL-12 Receptor β2-Chain Expression on CD4+ T Cells Resulting in a State of Unresponsiveness to IL-12

1998 • 112 citations

The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway

1999 • 111 citations

Tumor necrosis factor and immune interferon synergistically increase transcription of HLA class I heavy- and light-chain genes in vascular endothelium.

1990 • 109 citations

Interleukin 12 deficiency associated with recurrent infections

1998 • 107 citations

Analysis of Th1 and Th2 cytokine production by peripheral blood mononuclear cells as a parameter of immunological dysfunction in advanced cancer patients

1999 • 107 citations

Interleukin 4 mediates autocrine growth of helper T cells after antigenic stimulation.

1986 • 106 citations

The in vivo role of stem cell factor (c‐kit ligand) on mastocytosis and host protective immunity to the intestinal nematode Trichinella spiralis in mice

1993 • 106 citations

Correlations between worm burden and markers of Th1 and Th2 cell subset induction in an inbred strain of mouse infected with Trichuris muris

1993 • 106 citations

Induction of a Th2 population from a polarized Leishmania-specific Th1 population by in vitro culture with IL-4.

1995 • 104 citations

Molecular basis for the enhanced respiratory burst of activated macrophages.

1985 • 104 citations

IFN-γ-Mediated Control ofCoxiella burnetiiSurvival in Monocytes: The Role of Cell Apoptosis and TNF

1999 • 104 citations

Serum cortisol and DHEA concentrations during HIV infection

1997 • 104 citations

Modulation of Eosinophil Chemotaxis by Interleukin-5

1992 • 103 citations

Regulation of interleukin‐10 production by β‐adrenergic agonists

1996 • 102 citations

Sequential production of Th1 and Th2 cytokines in response to live bacillus Calmette-Guérin.

1995 • 102 citations

Acute exacerbation of liver disease during interferon alfa therapy for chronic hepatitis C

1992 • 101 citations

Membrane Capacitance Changes Associated with Particle Uptake during Phagocytosis in Macrophages

1998 • 100 citations

Specific inhibition of antibody production. I. Protein-over loading paralysis.

1962 • 99 citations

Disparate effects of interferon-gamma and tumor necrosis factor-alpha on early neutrophil respiratory burst and fungicidal responses to Candida albicans hyphae in vitro.

1991 • 98 citations

Adrenal Hormone Modulation of Type 1 and Type 2 Cytokine Production by Spleen Cells: Dexamethasone and Dehydroepiandrosterone Suppress Interleukin-2, Interleukin-4, and Interferon-γ Productionin Vitro

1998 • 97 citations

Assessment of Type 1 and Type 2 Cytokines in HIV Type 1-Infected Individuals: Impact of Highly Active Antiretroviral Therapy

1999 • 97 citations

Interleukin-12 regulation of host defenses against Coccidioides immitis

1996 • 95 citations

Induction of Th1 cell-mediated protective immunity to Schistosoma mansoni by co-administration of larval antigens and IL-12 as an adjuvant.

1996 • 95 citations

Interferon-gamma differentially regulates interleukin-12 and interleukin-10 production in leprosy.

1997 • 94 citations

HIV infection suppresses type 1 lymphokine and IL-12 responses to Toxoplasma gondii but fails to inhibit the synthesis of other parasite-induced monokines.

1995 • 93 citations

Clonal analysis of functionally distinct human CD4+ T cell subsets.

1988 • 93 citations

Cytokine Patterns at the Site of Mycobacterial Infection

1994 • 93 citations

Elevation of IgE in HIV-infected children and its correlation with the progression of disease

1995 • 93 citations

Outpatient Continuous Intravenous Interleukin‐2 or Subcutaneous, Polyethylene Glycol‐Modified Interleukin‐2 in Human Immunodeficiency Virus‐Infected Patients: A Randomized, Controlled, Multicenter Study

1998 • 92 citations

Interleukin‐12 promotes a chronic intestinal nematode infection

1997 • 92 citations

The Interleukin-12–Mediated Pathway of Immune Events Is Dysfunctional in Human Immunodeficiency Virus–Infected Individuals

1999 • 91 citations

Effect of Inhaled Interleukin-4 on Airway Hyperreactivity in Asthmatics

1998 • 91 citations

Clinical, hematologic, and immunologic effects of interleukin-10 in humans

1996 • 90 citations

Plasma catecholamine level and portal venous pressure as guides to prognosis in patients with cirrhosis

1988 • 90 citations

Resistance to Methylprednisolone in Cultures of Blood Mononuclear Cells from Glucocorticoid-Resistant Asthmatic Patients

1984 • 89 citations

The Nutritional Status in Advanced Emphysema Associated with Chronic Bronchitis: A Study of Amino Acid and Catecholamine Levels

1990 • 88 citations

Gamma interferon and interleukin 2, but not interleukin 4, are detectable in gamma/delta T-cell cultures after activation with bacteria

1992 • 87 citations

Alpha-Melanocyte-Stimulating Hormone Suppresses Antigen-Stimulated T Cell Production of Gamma-lnterferon

1994 • 87 citations

A possible role for the cortisol/anticortisols imbalance in the progression of human immunodeficiency virus

1997 • 87 citations

Saying the ‘S’ word in public

1993 • 87 citations

Mice withSTAT6-Targeted Gene Disruption Develop a Th1 Response and Control Cutaneous Leishmaniasis

1998 • 84 citations

Anti-proliferative effect of IFN-gamma in immune regulation. II. IFN-gamma inhibits the proliferation of murine bone marrow cells stimulated with IL-3, IL-4, or granulocyte-macrophage colony-stimulating factor.

1988 • 83 citations

Effectiveness of a Vaccine Composed of Heat-KilledCandida albicansand a Novel Mucosal Adjuvant, LT(R192G), against Systemic Candidiasis

1999 • 82 citations

Effects of subcutaneous interleukin-2 therapy on CD4 subsets and in vitro cytokine production in HIV+ subjects.

1997 • 82 citations

Biological activity of IL-4 and IL-13 on human endothelial cells: functional evidence that both cytokines act through the same receptor

1996 • 81 citations

Pseudomonas aeruginosa outer-membrane protein F epitopes are highly immunogenic in mice when expressed on a plant virus

1999 • 80 citations

Cytokine profile of circulating T cells of leprosy patients reflects both indiscriminate and polarized T-helper subsets: T-helper phenotype is stable and uninfluenced by related antigens of Mycobacterium leprae.

1995 • 80 citations

Oral Administration of Myelin Induces Antigen‐specific TGF‐β1 Secreting T Cells in Patients with Multiple Sclerosis^a

1997 • 80 citations

Differential effect of pregnancy or gestagens on humoral and cell-mediated immunity.

1977 • 79 citations

T cell subsets and IFN-gamma production in resistance to systemic candidosis in immunized mice.

1990 • 79 citations

Nonviable bacterial antigens administered with IL-12 generate antigen-specific T cell responses and protective immunity against Listeria monocytogenes.

1995 • 79 citations

Characterization and Comparison of the Interleukin 13 Receptor with the Interleukin 4 Receptor on Several Cell Types

1995 • 79 citations

The Catecholamine Response to Multisystem Trauma

1992 • 78 citations

Human immunodeficiency virus (HIV) phenotype and interleukin-2/ interleukin-10 ratio are associated markers of protection and progression in HIV infection

1996 • 78 citations

Infections in IFNGR-1-Deficient Children

1997 • 77 citations

The Use of Corticosteroids in the Treatment of Acute Asthma

1975 • 76 citations

Chronic mucocutaneous candidiasis. I. Altered antigen-stimulated IL-2, IL-4, IL-6 and interferon-gamma (IFN-γ) production

1996 • 75 citations

Decreased Serum Dehydroepiandrosterone Is Associated with an Increased Progression of Human Immunodeficiency Virus Infection in Men with CD4 Cell Counts of 200-499

1991 • 75 citations

Cytokine gene expression in human peripheral blood mononuclear cells stimulated by mannoprotein constituents from Candida albicans

1993 • 74 citations

Comparison of Lung Dendritic Cells and B Cells in Stimulating Naive Antigen-Specific T Cells

1999 • 73 citations

Generation, persistence, and modulation of Th0 effector cells: role of autocrine IL-4 and IFN-gamma.

1998 • 72 citations

Fc epsilonRI-deficient mice infected with Schistosoma mansoni mount normal Th2-type responses while displaying enhanced liver pathology.

1997 • 72 citations

CD4+ T-helper-cell responses in mice with low-level Candida albicans infection

1996 • 72 citations

Adrenal function in HIV infected patients

1989 • 71 citations

Induction of Protective Th1 Responses toCandida albicansby Antifungal Therapy Alone or in Combination with an Interleukin‐4 Antagonist

1997 • 71 citations

Accelerated cell-mediated immune reactions in penicillin allergy

1993 • 71 citations

Functional correlations between mucosal mast cell activity and immunity to Trichinella spiralis in high and low responder mice

1990 • 70 citations

Eosinophil survival activity identified as interleukin-5 is associated with eosinophil recruitment and degranulation and lung injury twenty-four hours after segmental antigen lung challenge

1993 • 70 citations

Suppression of superoxide anion production by interleukin-10 is accompanied by a downregulation of the genes for subunit proteins of NADPH oxidase.

1996 • 70 citations

Gamma interferon modifies CD4+ subset expression in murine candidiasis

1992 • 69 citations

IgE class switching is critically dependent upon the nature of the B cell activator, in addition to the presence of IL-4.

1991 • 68 citations

IL-12 transiently induces IFN-_γ transcription and protein synthesis in human CD4 ⁺ allergen-specific T_h2 T cell clones

1994 • 68 citations

Pharmacokinetics and leukocyte responses of recombinant human interleukin-10.

1998 • 68 citations

Differential Regulation of the IL-12 p40 Promoter and of p40 Secretion by CpG DNA and Lipopolysaccharide

1999 • 66 citations

Dehydroepiandrosterone as Predictor for Progression to AIDS in Asymptomatic Human Immunodeficiency Virus-Infected Men

1992 • 66 citations

Immunologic characterization of children vertically infected with human immunodeficiency virus, with slow or rapid disease progression

1995 • 64 citations

Increased Urinary Excretion of Cortisol and Catecholami-NES in Malnourished Cancer Patients

1988 • 64 citations

Mouse IL-13 Enhances Antibody Production In Vivo and Acts Directly on B Cells In Vitro to Increase Survival and Hence Antibody Production

1999 • 63 citations

Regulation and development of cytochrome c-specific IL-4-producing T cells.

1990 • 63 citations

The Possible Role of Interleukin (IL)-12 and Interferon-γ-Inducing Factor/IL-18 in Protection against ExperimentalMycobacterium lepraeInfection in Mice

1998 • 62 citations

Modulating effects of the feeding route on stress response and endotoxin translocation in severely stressed patients receiving thoracic esophagectomy

2000 • 62 citations

A double-blind, placebo-controlled study of Mycobacterium-specific human immune responses induced by intradermal bacille Calmette-Guérin vaccination

1999 • 61 citations

The viral clearance in interferon-treated chronic hepatitis C is associated with increased cytotoxic T cell frequencies

1999 • 61 citations

Qualitative and Quantitative Analysis of T Lymphocytes During Normal Human Pregnancy

1995 • 61 citations

Intrinsic Defects in Macrophage IL-12 Production Associated with Immune Dysfunction in the MRL/++ and New Zealand Black/White F1 Lupus-Prone Mice and theLeishmania major-Susceptible BALB/c Strain

1998 • 60 citations

Resistance toCoccidioides immitisin Mice after Immunization with Recombinant Protein or a DNA Vaccine of a Proline-Rich Antigen

1999 • 60 citations

The role of IL-12 in the maintenance of an established Th1 immune response in experimental leishmaniasis

1998 • 60 citations

Ultra low dose interleukin-2 therapy promotes a type 1 cytokine profile in vivo in patients with AIDS and AIDS-associated malignancies.

1998 • 59 citations

T‐cell cytokine pattern at three time points during specific immunotherapy for mite‐sensitive asthma

2000 • 59 citations

There is a bias against type 1 (inflammatory) cytokine expression and function in pregnancy

1996 • 58 citations

Liposomes containing interferon-gamma as adjuvant in tumor cell vaccines.

2000 • 58 citations

Expression and production of interleukin-10 by human trophoblast: relationship to pregnancy immunotolerance.

1997 • 58 citations

Glucocorticoids and the Immune Function in the Human Immunodeficiency Virus Infection: A Study in Hypercortisolemic and Cortisol-Resistant Patients*

1997 • 57 citations

Intracellular and Extracellular Cytokine Production by Human Mixed Mononuclear Cells in Response to Group B Streptococci

2000 • 57 citations

Pharmacokinetics and pharmacodynamics of three different prednisolone prodrugs: effect on circulating lymphocyte subsets and function.

1984 • 56 citations

A phase I/II study of recombinant human interleukin-12 in patients with chronic hepatitis C

1999 • 56 citations

Generation, Persistence, and Modulation of Th0 Effector Cells: Role of Autocrine IL-4 and IFN-γ

1998 • 56 citations

A PILOT TRIAL OF RECOMBINANT HUMAN INTERLEUKIN-10 IN KIDNEY TRANSPLANT RECIPIENTS RECEIVING OKT3 INDUCTION THERAPY1,2

1997 • 56 citations

Glucocorticoids Induce a TH2 Response In Vitro

1997 • 56 citations

Induction of Interleukin‐12 Production in Chronic Hepatitis C Virus Infection Correlates with the Hepatocellular Damage

1998 • 54 citations

Survival of Group BStreptococcusType III in Mononuclear Phagocytes: Differential Regulation of Bacterial Killing in Cord Macrophages by Human Recombinant Gamma Interferon and Granulocyte-Macrophage Colony-Stimulating Factor

2000 • 53 citations

Specific Inhibition of Antibody Formation During Immunological Paralysis and Unresponsiveness

1959 • 50 citations

Hypercortisolemia increases plasma interleukin-10 concentrations during human endotoxemia--a clinical research center study

1996 • 50 citations

Monocyte derived IL 10 and PGE2 are associated with the absence of Th 1 cells and in vitro T cell suppression in lepromatous leprosy

1995 • 49 citations

Lectin-mediated induction of IL-4-producing CD4+ T cells.

1991 • 48 citations

Delivery of Cytokines by Liposomes: Hematopoietic and Immunomodulatory Activity of Interleukin-2 Encapsulated in Conventional Liposomes and in Long-Circulating Liposomes

2000 • 48 citations

Low Dose Streptozotocin Induced Diabetes in Mice

2009 • 48 citations

Relationship between sex steroid hormone levels and CD4 lymphocytes in HIV infected men

2009 • 47 citations

Dysregulated production of interleukin-10 (IL-10) and IL-12 by peripheral blood lymphocytes from human immunodeficiency virus-infected individuals is associated with altered proliferative responses to recall antigens

1995 • 47 citations

Antibody to interleukin 5 prevents blood and tissue eosinophilia but not liver trapping in murine larval toxocariasis

1993 • 46 citations

Restoration of Normal Interleukin‐2 Production by CD4⁺T Cells of Human Immunodeficiency Virus–Infected Patients after 9 Months of Highly Active Antiretroviral Therapy

1999 • 44 citations

Immunostimulatory properties of genomic DNA from different bacterial species

1999 • 42 citations

Differential inhibitory effects of interleukin-10, interleukin-4, and dexamethasone on staphylococcal enterotoxin-induced cytokine production and T cell activation

1995 • 42 citations

The effect of tumor necrosis factor-α and interferon-γ on neutrophil function

1989 • 41 citations

Interferon Consensus Sequence Binding Protein Confers Resistance againstYersinia enterocolitica

2000 • 40 citations

Host Immune Reactivity Determines the Efficacy of Combination Immunotherapy and Antifungal Chemotherapy in Candidiasis

2000 • 40 citations

IL-3, IL-5, and granulocyte-macrophage colony-stimulating factor potentiate basophil mediator release stimulated by eosinophil granule major basic protein.

1995 • 40 citations

Th1 dominance in the immune response to live Salmonella typhimurium requires bacterial invasiveness but not persistence

1999 • 39 citations

The expression of IL-2, IL-4 and interferon-gamma (IFN-γ) mRNA using liver biopsies at different phases of acute exacerbation of chronic hepatitis B

1995 • 39 citations

Direct Interaction of STAT4 with the IL-12 Receptor

1999 • 38 citations

The concept of type 1 and type 2 antigen-presenting cells

1999 • 36 citations

Coexistence of Antigen-Specific TH1 and TH2 Cells in Genetically Susceptible BALB/c Mice Infected with Leishmania major

1989 • 36 citations

Activity and safety of DNA plasmids encoding IL-4 and IFN gamma

1999 • 34 citations

The Activated Type 1–Polarized Cd8+ T Cell Population Isolated from an Effector Site Contains Cells with Flexible Cytokine Profiles

1999 • 33 citations

Partial mediation of glucocorticoid antiproliferative effects by lipocortins.

1996 • 32 citations

Interleukin-4 suppresses antifungal activity of human mononuclear phagocytes against Candida albicans in association with decreased uptake of blastoconidia

2006 • 32 citations

IgE antibody and resistance to infection II. Effect of IgE suppression on the early and late skin reaction and resistance of rats to Schistosoma mansoni infection

1986 • 32 citations

Rapid fragmentation and reorganization of Golgi membranes during frustrated phagocytosis of immobile immune complexes by macrophages.

1989 • 31 citations

Peritoneal exudate T lymphocytes with specificity to sheep red blood cells. I. Production and characterization as to function and phenotype.

1979 • 30 citations

Glucocorticoids and interferon-alpha in the acquired immunodeficiency syndrome.

1996 • 30 citations

T cell receptor-independent immunosuppression induced by dexamethasone in murine T helper cells.

1992 • 30 citations

IL-4 Suppression of In Vivo T Cell Activation and Antibody Production

2000 • 29 citations

TheLeishmaniapromastigote surface antigen-2 (PSA-2) is specifically recognised by Th1 cells in humans with naturally acquired immunity toL. major

1998 • 28 citations

Concentration patterns of plasma dehydroepiandrosterone, Δ5-androstenediol and their sulphates, testosterone and cortisol in normal healthy women and in women with anorexia nervosa

1985 • 28 citations

The influence of base sequence on the immunostimulatory properties of DNA

1999 • 27 citations

Glucocorticoids and the Immune Function in the Human Immunodeficiency Virus Infection: A Study in Hypercortisolemic and Cortisol-Resistant Patients

1997 • 27 citations

Involvement of T Cells in Enhanced Resistance toKlebsiella pneumoniaeSepticemia in Mice Treated with Liposome-Encapsulated Muramyl Tripeptide Phosphatidylethanolamine or Gamma Interferon

1998 • 26 citations

Relationships between titers of antibodies immunoreacting against glycolipid antigens from Mycobacterium leprae and M. tuberculosis, the Mitsuda and Mantoux reactions, and bacteriological loads: implications in the pathogenesis, epidemiology and serodiagnosis of leprosy and tuberculosis.

1992 • 26 citations

Dysregulation of immune response following neurosurgical operations

2000 • 25 citations

Leishmania major: Analysis of lymphocyte and macrophage cellular phenotypes during infection of susceptible and resistant mice

1988 • 24 citations

EFFECTS OF A CORTICOSTEROID, BUDESONIDE, ON PRODUCTION OF BIOACTIVE IL-12 BY HUMAN MONOCYTES

1998 • 24 citations

Influence of alpha-melanocyte stimulating hormone on induction of contact hypersensitivity and tolerance

1994 • 23 citations

Recombinant Interleukin 2 Adjunctive Therapy in Multidrug‐Resistant Tuberculosis

1998 • 23 citations

The role of type I interferons in the differentiation and function of Th1 and Th2 cells.

1997 • 23 citations

Interleukin-5 mRNA levels in blood and bone marrow mononuclear cells from patients with the idiopathic hypereosinophilic syndrome.

1994 • 22 citations

Interrelationship of eosinophilia and IgE antibody production to larval ES antigen in Toxocara canis infected mice

1984 • 21 citations

Administration of Dehydroepiandrosterone Reverses the Immune Suppression Induced by High Dose Antigen in Mice

1995 • 21 citations

<i>Haemophilus influenzae</i> and <i>Streptococcus pyogenes</i> Group A Challenge Induce a Th<sub>1</sub> Type of Cytokine Response in Cells Obtained from Tonsillar Hypertrophy and Recurrent Tonsillitis

1998 • 21 citations

Free and conjugated plasma catecholamines in patients with congestive heart failure.

1984 • 21 citations

Schistosoma mansoni:Protective Immunity in IL-4-Deficient Mice

1996 • 21 citations

Glucocorticoids and interferon-alpha in the acquired immunodeficiency syndrome

1996 • 20 citations

Dissociative effects of malarial infection on humoral and cell-mediated immunity in mice.

1979 • 20 citations

Degranulation of human basophils bypicomolar concentrations of IL–3, IL–5, orgranulocyte-macrophage colony-stimulating factor☆☆☆★★★

1998 • 20 citations

TH1 pattern of cytokine secretion by splenic cells from pyelonephritic mice after in-vitro stimulation with hsp-65 of Escherichia coli

1997 • 19 citations

Use of recombinant viruses to deliver cytokines influencing the course of experimental bacterial infection

1999 • 19 citations

Th1-biased immune responses induced by DNA-based immunizations are mediated via action on professional antigen-presenting cells to up-regulate IL-12 production

2000 • 18 citations

Antigen presentation by hapten-specific B lymphocytes. V. Requirements for activation of antigen-presenting B cells.

1987 • 17 citations

Peritoneal exudate T lymphocytes with specificity to sheep red blood cells. II. Inflammatory helper T cells and effector T cells in mice with delayed-type hypersensitivity and in suppressed mice.

1979 • 16 citations

Vaccination promotes TH1-like inflammation and survival in chronic Pseudomonas aeruginosa pneumonia. A new prophylactic principle.

1997 • 15 citations

Low-Dose Streptozotocin-Induced Diabetes in Mice

1993 • 15 citations

Polymorphonuclear neutrophils release ³⁵S‐labelled proteoglycans into cartilage during frustrated phagocytosis

1994 • 15 citations

Leishmania major infection in interleukin-4 and interferon-gamma depleted mice

1999 • 14 citations

Long-Lived Protective Immunity toListeriaIs Conferred by Immunization with Particulate or Soluble Listerial Antigen Preparations Coadministered with IL-12

1998 • 13 citations

Immune response to chemically modified flagellin

1973 • 13 citations

Effect of nutritional therapy on polyamine metabolism in severely traumatized patients.

1991 • 13 citations

Effect of Inhaled Interleukin-5 on Number and Activity of Eosinophils in Circulation from Asthmatics

1999 • 13 citations

Two distinct non‐T helper type 2 interleukin‐4 cell subsets in mice as revealed by single‐cell cytokine analysis

1994 • 12 citations

Antibody Responses and Protective Immunity in Rats Receiving Repeated Inoculations of Strongyloides ratti

1991 • 11 citations

Coadministration of Zidovudine and Interleukin‐2 Increases Absolute CD4 Cells in Subjects with Walter Reed Stage 2 Human Immunodeficiency Virus Infection: Results of ACTG Protocol 042

1998 • 11 citations

The influence of interferon-γ and various phagocytic stimuli on the expression of MHC-class II antigens on human monocytes — relation to the generation of reactive oxygen intermediates

1986 • 11 citations

Hepatitis B Core Antigen-Specific Interferon Gamma Production of Peripheral Blood Mononuclear Cells during Acute Exacerbation of Chronic Hepatitis B

1992 • 11 citations

Novel diversity in Th1, Th2 type differentiation of hemagglutinin-specific T cell clones elicited by natural influenza virus infection in three major haplotypes (H-2b,d,k).

1998 • 10 citations

Novel Diversity in Th1, Th2 Type Differentiation of Hemagglutinin-Specific T Cell Clones Elicited by Natural Influenza Virus Infection in Three Major Haplotypes (H-2b,d,k)

1998 • 9 citations

Temporal changes in Trichuris trichiura infection intensity and serum isotype responses in children

1994 • 8 citations

Modulation of IgE Production in the Mouse by β<sub>2</sub>-Adrenoceptor Agonist

1994 • 8 citations

Effects of interferons, interferon inducers and growth factors on phagocytosis measured by quantitative determination of synthetic compound ingested by mouse bone marrow-derived macrophages.

1988 • 7 citations

Severe Exacerbation of Chronic Active Hepatitis B during Interferon Alpha Therapy

1992 • 7 citations

Hormonal profiles in children with progressively worsening nutritional status.

1982 • 5 citations

Endogenous Interleukin‐2 Serum Levels in Children Infected with Human Immunodeficiency Virus

1997 • 5 citations

Current laboratory assays and in vitro intracellular Th1 and Th2 cytokine synthesis in monitoring antiretroviral therapy of pediatric HIV infection

2000 • 5 citations