Effect of Inhaled Interleukin-5 on Number and Activity of Eosinophils in Circulation from Asthmatics

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

Recombinant human interleukin 5 is a selective activator of human eosinophil function.

1988 • 976 citations

Eosinophils and Mast Cells in Bronchoalveolar Lavage in Subjects with Mild Asthma: Relationship to Bronchial Hyperreactivity

1988 • 905 citations

The eosinophil and bronchial asthma: Current understanding

1990 • 688 citations

Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF

1989 • 676 citations

Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo.

1995 • 657 citations

Antibody to Interleukin-5 Inhibits Helminth-Induced Eosinophilia in Mice

1989 • 635 citations

Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma

1988 • 635 citations

Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor.

1988 • 619 citations

Total Eosinophil Counts in the Management of Bronchial Asthma

1975 • 397 citations

Regulatory effect of cytokines on eosinophil degranulation.

1990 • 337 citations

Human eosinophil major basic protein induces airway constriction and airway hyperresponsiveness in primates.

1991 • 310 citations

The effect of immunotherapy on bronchial hyperresponsiveness and eosinophil cationic protein in pollen-allergic patients

1988 • 268 citations

Interleukin 5 enhances interleukin 4‐induced IgE production by normal human B cells. The role of soluble CD23 antigen

1988 • 265 citations

CD4 T-Lymphocyte Activation in Asthma Is Accompanied by Increased Serum Concentrations of Interleukin-5: Effect of Glucocorticoid Therapy

1993 • 264 citations

Cytokines as Mediators of Chronic Asthma

1994 • 194 citations

Effect of Inhaled Interleukin-5 on Airway Hyperreactivity and Eosinophilia in Asthmatics

1998 • 179 citations

Mechanism of Airway Inflammation in Asthma

1993 • 168 citations

Peripheral blood eosinophil counts and bronchial responsiveness.

1987 • 161 citations

Blood eosinophil number and activity in relation to lung function in patients with asthma and with eosinophilia

1991 • 142 citations

Cellular infiltration of the airways in asthma of varying severity.

1996 • 137 citations

Eosinophil Granule Proteins in Serum after Allergen Challenge of Asthmatic Patients and the Effects of Anti-Asthmatic Medication

1988 • 92 citations

In vivo neutralization of eosinophil-derived major basic protein inhibits antigen-induced bronchial hyperreactivity in sensitized guinea pigs.

1996 • 85 citations

The Role of the Eosinophil in Asthma

1991 • 81 citations

Infiltration of eosinophils into the asthmatic airways caused by interleukin 5.

1997 • 81 citations

Airway eosinophilic inflammation, epithelial damage, and bronchial hyperresponsiveness in patients with mild‐moderate, stable asthma

1996 • 70 citations

Eosinophil cationic protein(ECP) and eosinophil protein X (EXP) concentrations in serum and bronchial lavage fluid in asthma. effect of prednisolone treatment.

1995 • 64 citations

Serum eosinophil cationic protein in relation to bronchial asthma in a young Swedish population

1994 • 54 citations

Serum interleukin 5 concentrations in atopic and non-atopic patients with glucocorticoid-dependent chronic severe asthma.

1994 • 51 citations

Late-phase asthmatic responses and airway inflammation

1989 • 47 citations

Inflammatory cell number and mediators in bronchoalveolar lavage fluid and peripheral blood in subjects with asthma with increased nocturnal airways narrowing

1995 • 47 citations

Are blood eosinophil number and activity important for the development of the late asthmatic reaction after allergen challenge?

1989 • 44 citations

Immunohistochemical detection of GM‐CSF, IL‐4 and IL‐5 in a murine model of allergic bronchopulmonary aspergillosis

1996 • 40 citations

Serum concentrations of IL‐5, GM‐CSF, and IL‐3 and the production by lymphocytes in various eosinophilia

1995 • 17 citations

Interleukin-5 messenger RNA expression in peripheral blood CD4+ cells in asthma

1996 • 15 citations

Rapid and selective induction of blood eosinophilia in guinea pigs by recombinant human interleukin 5

1995 • 11 citations

Serum Concentrations of lnterleukin-5 and the Production of Lymphocytes in Reactive Eosinophilia

1995 • 2 citations