IL-13, IL-4Rα, and Stat6 Are Required for the Expulsion of the Gastrointestinal Nematode Parasite Nippostrongylus brasiliensis

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

1994 • 888 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

CYTOKINE REGULATION OF HOST DEFENSE AGAINST PARASITIC GASTROINTESTINAL NEMATODES:Lessons from Studies with Rodent Models^*

1997 • 648 citations

The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms

1989 • 645 citations

Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction.

1993 • 457 citations

Cytokine-mediated regulation of chronic intestinal helminth infection.

1994 • 425 citations

Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1.

1985 • 410 citations

Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor.

1996 • 406 citations

Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines.

1983 • 377 citations

Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice.

1991 • 376 citations

Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis.

1997 • 363 citations

Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes.

1993 • 352 citations

An interleukin 4 (IL-4)-independent pathway for CD4⁺T cell IL-4 production is revealed in IL-4 receptor-deficient mice

1997 • 334 citations

Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites.

1994 • 281 citations

Cloning and Characterization of a Specific Interleukin (IL)-13 Binding Protein Structurally Related to the IL-5 Receptor α Chain

1996 • 278 citations

Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis.

1991 • 266 citations

Receptor for Interleukin 13

1995 • 266 citations

Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice.

1996 • 243 citations

The Primary Binding Subunit of the Human Interleukin-4 Receptor Is Also a Component of the Interleukin-13 Receptor

1995 • 236 citations

Low-affinity IgE receptor (CD23) function on mouse B cells: role in IgE-dependent antigen focusing.

1989 • 233 citations

[39] Vectors used for expression in mammalian cells

1990 • 188 citations

A Single Tyrosine of the Interleukin-9 (IL-9) Receptor Is Required for STAT Activation, Antiapoptotic Activity, and Growth Regulation by IL-9

1996 • 182 citations

Generation of hybridomas secreting murine reaginic antibodies of anti-DNP specificity.

1980 • 176 citations

IL-4 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice.

1995 • 166 citations

Growth and Gene Expression Are Predominantly Controlled by Distinct Regions of the Human IL-4 Receptor

1996 • 158 citations

The role of L3T4+ and Lyt-2+ T cells in the IgE response and immunity to Nippostrongylus brasiliensis.

1988 • 138 citations

Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line

1996 • 137 citations

Both Interleukin 4 and Interleukin 13 Induce Tyrosine Phosphorylation of the 140-kDa Subunit of the Interleukin 4 Receptor

1995 • 137 citations

Effects of Immunity on Nippostrongylus brasiliensis Adult Worms: Reversible and Irreversible Changes in Infectivity, Reproduction, and Morphology

1968 • 135 citations

Interleukin-4 and Interleukin-13 Differentially Regulate Epithelial Chloride Secretion

1996 • 133 citations

Inhibition of IgE binding to mast cells and basophils by monoclonal antibodies to murine IgE

1984 • 128 citations

Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation.

1995 • 118 citations

Receptors for Interleukin (IL)-4 Do Not Associate with the Common γChain, and IL-4 Induces the Phosphorylation of JAK2 Tyrosine Kinase in Human Colon Carcinoma Cells

1995 • 117 citations

IFN inhibits inflammatory responses and protective immunity in mice infected with the nematode parasite, Nippostrongylus brasiliensis.

1993 • 95 citations

IL-4 Function Can Be Transferred to the IL-2 Receptor by Tyrosine Containing Sequences Found in the IL-4 Receptor α Chain

1996 • 90 citations

Induction of an IgE response in mice by Nippostrongylus brasiliensis: characterization of lymphoid cells with intracytoplasmic or surface IgE.

1983 • 89 citations

A role for IgE in intestinal immunity. Expression of rapid expulsion of Trichinella spiralis in rats transfused with IgE and thoracic duct lymphocytes.

1991 • 78 citations

Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor.

1995 • 73 citations

Monoclonal antibodies block murine IL-4 receptor function.

1990 • 70 citations

Differential activation of myotube nuclei following exposure to an acetylcholine receptor-inducing factor

1989 • 69 citations

Polyclonal activation of the murine immune system by an antibody to IgD. II. Generation of polyclonal antibody production and cells with surface IgG.

1982 • 68 citations

Interleukin 13 elicits a subset of the activities of its close relative interleukin 4

1994 • 66 citations

Human interleukin‐13 activates the interleukin‐4‐dependent transcription factor NF‐IL4 sharing a DNA binding motif with an interferon‐γ‐induced nuclear binding factor

1994 • 57 citations

Biological activities of antitrinitrophenyl and antidinitrophenyl mouse monoclonal antibodies.

1982 • 50 citations

Characterization of the immune mediator of rapid expulsion of Trichinella spiralis in suckling rats.

1987 • 39 citations

The insulin receptor substrate-1-related 4PS substrate but not the interleukin-2R gamma chain is involved in interleukin-13-mediated signal transduction

1995 • 39 citations

Toxocara canis: Failure to Find IgE Receptors (Fc∈R) on Eosinophils from Infected Mice Suggests That Murine Eosinophils Do Not Kill Helminth Larvae by an IgE-Dependent Mechanism

1994 • 37 citations

Polyclonal activation of the murine immune system by an antibody to IgD III. Ontogeny

1983 • 32 citations

Anti-IL-4 antibody inhibits antigen specific IgE response but fails to prevent chicken gamma globulin-induced active systemic anaphylaxis: evidence for the involvement of IgG antibodies

1996 • 8 citations

Comparative study of 1.5-hour and 48-hour homologous passive cutaneous anaphylaxis in the mouse ear.

1988 • 6 citations