Leishmania major infection in interleukin-4 and interferon-gamma depleted mice

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Recombinant interleukin 12 cures mice infected with Leishmania major.

1993 • 776 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

1993 • 738 citations

A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma.

1986 • 727 citations

Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

1988 • 713 citations

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.

1990 • 629 citations

Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.

1991 • 528 citations

IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis.

1991 • 526 citations

Role of Cytokines and CD4+ T‐Cell Subsets in the Regulation of Parasite Immunity and Disease

1989 • 405 citations

IL-4 induces a Th2 response in Leishmania major-infected mice.

1992 • 403 citations

CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major.

1994 • 397 citations

Strategies of Anti‐Cytokine Monoclonal Antibody Development: Immunoassay of IL‐10 and IL‐5 in Clinical Samples

1992 • 384 citations

Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major.

1989 • 374 citations

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.

1994 • 365 citations

Interleukin‐4 and interleukin‐10 synergize to inhibit cell‐mediated immunity in vivo

1993 • 341 citations

Effects of IL-12 on helper T cell-dependent immune responses in vivo.

1994 • 294 citations

Susceptibility to Leishmania major Infection in Interleukin-4-Deficient Mice

1996 • 292 citations

Role of Cytokines in the Differentiation of CD4⁺ T‐Cell Subsets in vivo

1991 • 289 citations

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

1993 • 275 citations

IL-4-deficient Balb/c mice resist infection with Leishmania major.

1996 • 273 citations

Cytokine-Induced Synthesis of Nitrogen Oxides in Macrophages: A Protective Host Response to Leishmania and Other Intracellular Pathogens

1991 • 267 citations

Mice from a genetically resistant background lacking the interferon γ receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response.

1995 • 242 citations

Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice.

1985 • 225 citations

Murine cutaneous leishmaniasis: resistance correlates with the capacity to generate interferon-gamma in response to Leishmania antigens in vitro.

1986 • 169 citations

Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice.

1995 • 162 citations

Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major.

1994 • 137 citations

Interleukin‐4 transgenic mice of resistant background are susceptible to Leishmania major infection

1993 • 95 citations

Targeted activation of CD8 cells and infection of beta 2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis.

1993 • 89 citations

Reconstitution of C.B‐17 scid mice with BALB/c T cells initiates a T helper type‐1 response and renders them capable of healing Leishmania major infection

1993 • 78 citations

Experimental Leishmania major infection in mice: role of IL‐10

1999 • 77 citations

Development of rat anti-mouse interleukin 3 monoclonal antibodies which neutralize bioactivity in vitro.

1988 • 75 citations

Leishmania major infection in mice: a model system for the study of CD4+ T-cell subset differentiation

1991 • 55 citations

Cytokine regulation of murine leishmaniasis: interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice

1991 • 50 citations

Resistance to cutaneous leishmaniasis in nude mice injected with L3T4⁺ T cells but not with Ly‐2⁺ T cells

1988 • 49 citations

Nitrogen and oxygen metabolites and the killing of Leishmania by activated murine macrophages

1991 • 36 citations

IFN-γ produced in vivo during the first two days is critical for resolution of murine Leishmania major infections

1993 • 14 citations

Early message expression of interleukin‐4 and interferon‐γ, but not of interleukin‐2 and interleukin‐10, reflects later polarization of primary CD4⁺ T cell cultures

1996 • 13 citations

Cited By (0)

Loading...