Instruction for Cytokine Expression in T Helper Lymphocytes in Relation to Proliferation and Cell Cycle Progression

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Discrete Multivariate Analysis: Theory and Practice.

1975 • 5,202 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Taxol stabilizes microtubules in mouse fibroblast cells.

1980 • 1,942 citations

Discrete Multivariate Analysis

1977 • 1,841 citations

Discrete Multivariate Analysis: Theory and Practice.

1976 • 1,835 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

High gradient magnetic cell separation with MACS

1990 • 1,648 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

A cell-surface molecule involved in organ-specific homing of lymphocytes

1983 • 1,515 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase

1997 • 1,251 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6

1997 • 921 citations

Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-α

1978 • 904 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

1983 • 861 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

1997 • 783 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Activation of cAMP and mitogen responsive genes relies on a common nuclear factor

1994 • 730 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

New perspectives of C1328-137-mediated T cell costimulation

1995 • 526 citations

Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice

1995 • 491 citations

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.

1996 • 437 citations

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

1995 • 429 citations

Production of large numbers of mitotic mammalian cells by use of the reversible microtubule inhibitor Nocodazole

1980 • 389 citations

Strategies of Anti‐Cytokine Monoclonal Antibody Development: Immunoassay of IL‐10 and IL‐5 in Clinical Samples

1992 • 384 citations

DNA methylation and imprinting: why bother?

1997 • 370 citations

The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells

1984 • 368 citations

Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues

1982 • 359 citations

Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein

1997 • 343 citations

An interleukin 4 (IL-4)-independent pathway for CD4⁺T cell IL-4 production is revealed in IL-4 receptor-deficient mice

1997 • 334 citations

Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation

1998 • 332 citations

Flow cytometric determination of cytokines in activated murine T helper lymphocytes: Expression of interleukin‐10 in interferon‐γ and in interleukin‐4‐expressing cells

1994 • 305 citations

c-maf Promotes T Helper Cell Type 2 (Th2) and Attenuates Th1 Differentiation by Both Interleukin 4–dependent and –independent Mechanisms

1998 • 303 citations

Lack of Interferon γ Receptor β Chain and the Prevention of Interferon γ Signaling in T_H1 Cells

1995 • 292 citations

Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level.

1996 • 287 citations

Independent and Epigenetic Regulation of the Interleukin-4 Alleles in CD4 ⁺ T Cells

1998 • 250 citations

Monoallelic Expression of the Interleukin-2 Locus

1998 • 232 citations

Ligand-Induced Autoregulation of IFN-γ Receptor β Chain Expression in T Helper Cell Subsets

1995 • 219 citations

Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene.

1994 • 203 citations

A reversible arrest point in the late G1 phase of the mammalian cell cycle

1990 • 203 citations

Nuclear Factor of Activated T Cells (NFAT)-dependent Transactivation Regulated by the Coactivators p300/CREB-binding Protein (CBP)

1998 • 193 citations

A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation.

1996 • 182 citations

Cytokine transcriptional events during helper T cell subset differentiation.

1996 • 174 citations

Distinct Methylation of the Interferon γ (IFN-γ) and Interleukin 3 (IL-3) Genes in Newly Activated Primary CD8+ T Lymphocytes: Regional IFN-γ Promoter Demethylation and mRNA Expression Are Heritable in CD44highCD8+ T Cells

1998 • 171 citations

Regulation of IL-4 Expression by Activation of Individual Alleles

1998 • 170 citations

Stability of T_h1 and T_h2 populations

1995 • 158 citations

Monoclonal antibodies against murine gamma interferon.

1984 • 153 citations

T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6

1998 • 148 citations

Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen

1993 • 147 citations

Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

1998 • 139 citations

p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6

1999 • 126 citations

Hypomethylation of the interferon‐γ gene correlates with its expression by primary T‐lineage cells

1995 • 113 citations

Sequential production of IL-2, IFN-γ and IL-10 by individual staphylococcal enterotoxin B-activated T helper lymphocytes

1998 • 106 citations

Mice with a Fluorescent Marker for Interleukin 2 Gene Activation

1998 • 100 citations

STAT6 Is Required for the Anti-inflammatory Activity of Interleukin-4 in Mouse Peritoneal Macrophages

1998 • 98 citations

Impaired Interleukin 4 Signaling in T Helper Type 1 Cells

1998 • 94 citations

T1/ST2 Expression Is Enhanced on CD4+ T Cells from Schistosome Egg-Induced Granulomas: Analysis of Th Cell Cytokine Coexpression Ex Vivo

1999 • 71 citations

Commitment of individual Th1-like lymphocytes to expression of IFN-gamma versus IL-4 and IL-10: selective induction of IL-10 by sequential stimulation of naive Th cells with IL-12 and IL-4.

1998 • 54 citations

Commitment of Individual Th1-Like Lymphocytes to Expression of IFN-γ Versus IL-4 and IL-10: Selective Induction of IL-10 by Sequential Stimulation of Naive Th Cells with IL-12 and IL-4

1998 • 41 citations

Interleukin 2, 4 and 5 are sequentially produced in mitogen‐stimulated murine spleen cell cultures

1990 • 35 citations