Peptide Dose, Affinity, and Time of Differentiation Can Contribute to the Th1/Th2 Cytokine Balance

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.

1995 • 699 citations

Induction of T _H 1 and T _H 2 Immunity in Neonatal Mice

1996 • 671 citations

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

1995 • 577 citations

Establishment of Stable, Cell-Mediated Immunity that Makes "Susceptible" Mice Resistant to Leishmania major

1992 • 503 citations

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

1997 • 460 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis

1995 • 422 citations

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

1997 • 419 citations

Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo.

1995 • 410 citations

Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

1997 • 402 citations

Differential ability of T_h1 and T_h2 T cells to express Fas ligand and to undergo activation-induced cell death

1994 • 329 citations

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

1995 • 323 citations

A direct role for IFN-gamma in regulation of Th1 cell development.

1996 • 304 citations

CD28 costimulation promotes the production of Th2 cytokines.

1997 • 299 citations

Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation.

1997 • 273 citations

Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response.

1995 • 271 citations

Interleukin 4 production by CD4+ T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type.

1995 • 271 citations

From Naive to Memory T Cells

1996 • 252 citations

Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements.

1992 • 239 citations

Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis.

1994 • 234 citations

Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice.

1996 • 198 citations

Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon gamma by T cells.

1995 • 178 citations

B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens.

1997 • 172 citations

Induction of IL-4-producing CD4+ T cells by antigenic peptides altered for TCR binding.

1997 • 163 citations

Aqueous antigens induce in vivo tolerance selectively in IL-2- and IFN-gamma-producing (Th1) cells.

1992 • 163 citations

Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells.

1994 • 158 citations

B7–2 (CD86) is essential for the development of IL-4-producing T cells

1996 • 150 citations

Neonatal peptide exposure can prime T cells and, upon subsequent immunization, induce their immune deviation: implications for antibody vs. T cell-mediated autoimmunity.

1996 • 149 citations

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis.

1996 • 144 citations

Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines.

1995 • 144 citations

In vivo role of interleukin 4 in T cell tolerance induced by aqueous protein antigen.

1993 • 140 citations

The injection of deaggregated gamma globulins in adult mice induces antigen-specific unresponsiveness of T helper type 1 but not type 2 lymphocytes.

1992 • 139 citations

Low‐level infection with Trichuris muris significantly affects the polarization of the CD4 response

1994 • 137 citations

Impaired Th2 Subset Development in the Absence of CD4

1997 • 124 citations

CD28 activation promotes Th2 subset differentiation by human CD4⁺ cells

1995 • 122 citations

Human naive CD4 T cells produce interleukin‐4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions

1995 • 104 citations

Effect of pH on MHC class II-peptide interactions.

1992 • 101 citations

Genes that regulate interleukin-4 expression in T cells

1997 • 87 citations

Comparison of Th1- and Th2-associated immune reactivities stimulated by single versus multiple vaccination of mice with irradiated Schistosoma mansoni cercariae.

1991 • 82 citations

Costimulation of IL-4 production by murine B7-1 and B7-2 molecules.

1996 • 79 citations

CD28‐deficient mice generate an impaired Th2 response to Schistosoma mansoni infection

1996 • 77 citations

High Antigen Density and IL-2 Are Required for Generation of CD4 Effectors Secreting Th1 Rather Than Th0 Cytokines

1998 • 74 citations

Generation, persistence, and modulation of Th0 effector cells: role of autocrine IL-4 and IFN-gamma.

1998 • 72 citations

CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response.

1997 • 70 citations

A Role for CD4 in Peripheral T Cell Differentiation

1997 • 70 citations

Central role for TCR/CD3 ligation in the differentiation of CD4+ T cells toward A Th1 or Th2 functional phenotype.

1992 • 69 citations

Autopathogenic T Helper Cell Type 1 (Th1) and Protective Th2 Clones Differ in Their Recognition of the Autoantigenic Peptide of Myelin Proteolipid Protein

1997 • 66 citations

CD40 ligand induction on T cell subsets by peptide-presenting B cells: implications for development of the primary T and B cell response.

1997 • 60 citations

Modulation of Naive CD4 T Cell Activation with Altered Peptide Ligands: The Nature of the Peptide and Presentation in the Context of Costimulation Are Critical for a Sustained Response

1998 • 57 citations

B7-2 blockade enhances T cell responses to Leishmania donovani.

1997 • 56 citations

Generation, Persistence, and Modulation of Th0 Effector Cells: Role of Autocrine IL-4 and IFN-γ

1998 • 56 citations

MHC genotype controls the capacity of ligand density to switch T helper (Th)-1/Th-2 priming in vivo.

1996 • 56 citations

B7-2 requirement for helminth-induced granuloma formation and CD4 type 2 T helper cell cytokine expression.

1997 • 55 citations

Lectin-mediated induction of IL-4-producing CD4+ T cells.

1991 • 48 citations

Soluble protein but not peptide administration diverts the immune response of a clonal CD4+ T cell population to the T helper 2 cell pathway.

1996 • 44 citations

Altered TCR ligands affect antigen-presenting cell responses: up-regulation of IL-12 by an analogue peptide.

1996 • 40 citations