SR proteins are required for nematode trans-splicing in vitro

Exon Recognition in Vertebrate Splicing

1995 • 1,067 citations

SR proteins: a conserved family of pre-mRNA splicing factors.

1992 • 766 citations

Specific interactions between proteins implicated in splice site selection and regulated alternative splicing

1993 • 741 citations

THE STRUCTURE AND FUNCTION OF PROTEINS INVOLVED IN MAMMALIAN PRE-mRNA SPLICING

1996 • 687 citations

The superfamily of arginine/serine-rich splicing factors.

1995 • 671 citations

SR proteins and splicing control.

1996 • 668 citations

A trans-spliced leader sequence on actin mRNA in C. elegans

1987 • 639 citations

Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

1994 • 622 citations

Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors

1994 • 612 citations

A serine kinase regulates intracellular localization of splicing factors in the cell cycle

1994 • 511 citations

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

1990 • 500 citations

The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites

1990 • 454 citations

Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing

1993 • 407 citations

Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.

1997 • 394 citations

Trans splicing of nuclear pre-mRNAs

1990 • 383 citations

Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.

1990 • 359 citations

Cross-Intron Bridging Interactions in the Yeast Commitment Complex Are Conserved in Mammals

1997 • 342 citations

A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA

1993 • 332 citations

The Splicing Factor BBP Interacts Specifically with the Pre-mRNA Branchpoint Sequence UACUAAC

1997 • 327 citations

A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding.

1993 • 300 citations

The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing.

1996 • 286 citations

General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer.

1993 • 286 citations

Initial splice-site recognition and pairing during pre-mRNA splicing

1996 • 281 citations

Specific commitment of different pre-mRNAs to splicing by single SR proteins

1993 • 272 citations

Protein functions in pre-mRNA splicing

1997 • 272 citations

SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex.

1994 • 267 citations

The SR protein family: pleiotropic functions in pre-mRNA splicing

1996 • 259 citations

Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains.

1993 • 243 citations

General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection.

1992 • 241 citations

U1 snRNP targets an essential splicing factor, U2AF65, to the 3' splice site by a network of interactions spanning the exon.

1992 • 225 citations

Regulation of adenovirus alternative RNA splicing by dephosphorylation of SR proteins

1998 • 220 citations

Trans splicing involves a novel form of small nuclear ribonucleoprotein particles

1988 • 210 citations

Arginine/Serine-Rich Domains of SR Proteins Can Function as Activators of Pre-mRNA Splicing

1998 • 207 citations

Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2

1998 • 200 citations

Purification and characterization of a kinase specific for the serine- and arginine-rich pre-mRNA splicing factors.

1994 • 199 citations

The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3' splice site.

1992 • 198 citations

A monoclonal antibody that recognizes a phosphorylated epitope stains lampbrush chromosome loops and small granules in the amphibian germinal vesicle.

1990 • 193 citations

Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro.

1997 • 192 citations

Pathways for selection of 5′ splice sites by U1 snRNPs and SF2/ASF.

1993 • 192 citations

Functional domains of the human splicing factor ASF/SF2.

1993 • 188 citations

Finding splice sites within a wilderness of RNA.

1995 • 188 citations

Short leader sequences may be transferred from small RNAs to pre-mature mRNAs by trans-splicing in Euglena.

1991 • 181 citations

A Subset of SR Proteins Activates Splicing of the Cardiac Troponin T Alternative Exon by Direct Interactions with an Exonic Enhancer

1995 • 180 citations

Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways.

1995 • 174 citations

SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome.

1995 • 167 citations

SR proteins can compensate for the loss of U1 snRNP functions in vitro.

1994 • 160 citations

Mammalian splicing factor SF1 is encoded by variant cDNAs and binds to RNA.

1996 • 153 citations

Complementation by SR Proteins of Pre-mRNA Splicing Reactions Depleted of U1 snRNP

1994 • 152 citations

A spliced leader is present on a subset of mRNAs from the human parasite Schistosoma mansoni.

1990 • 144 citations

The C. elegans Trans-spliced leader RNA is bound to Sm and has a trimethylguanosine cap

1988 • 139 citations

Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity.

1995 • 133 citations

Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing.

1992 • 131 citations

Protein Phosphorylation Plays an Essential Role in the Regulation of Alternative Splicing and Sex Determination in Drosophila

1998 • 115 citations

Regulation of pre-mRNA splicing in metazoa

1997 • 110 citations

The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites.

1994 • 107 citations

Human SR Proteins and Isolation of a cDNA Encoding SRp75

1993 • 105 citations

Trans-spliced leader RNA exists as small nuclear ribonucleoprotein particles in Caenorhabditis elegans

1988 • 104 citations

Distinct functions of SR proteins in recruitment of U1 small nuclear ribonucleoprotein to alternative 5' splice sites.

1995 • 102 citations

A two-step mechanism for 5' and 3' splice-site pairing

1995 • 94 citations

Trans splicing of nematode pre-messenger RNA in vitro

1990 • 93 citations

Spliced leader RNA sequences can substitute for the essential 5′ end of U1 RNA during splicing in a mammalian in vitro system

1990 • 92 citations

Modulation of 5' splice site choice in pre-messenger RNA by two distinct steps.

1995 • 86 citations

Spliced leader RNAs from lower eukaryotes are trans- spliced in mammalian cells

1992 • 84 citations

Characterization and Expression of a Spliced Leader RNA in the Parasitic Nematode Ascaris lumbricoides var. suum

1989 • 78 citations

Bimolecular Exon Ligation by the Human Spliceosome

1997 • 74 citations

U small nuclear ribonucleoprotein requirements for nematode cis- and trans-splicing in vitro.

1991 • 73 citations

Enhancer-dependent interaction between 5' and 3' splice sites in trans.

1995 • 64 citations

The SR protein family: pleiotropic functions in pre-mRNA splicing

1996 • 62 citations

Developmental regulation of SR protein phosphorylation and activity

1999 • 61 citations

Direct analysis of nematode cis- and trans-spliceosomes: a functional role for U5 snRNA in spliced leader addition trans-splicing and the identification of novel Sm snRNPs.

1996 • 53 citations

SC35-mediated reconstitution of splicing in U2AF-depleted nuclear extract

1997 • 43 citations

Multiple requirements for nematode spliced leader RNP function in trans-splicing.

1996 • 43 citations

The nematode spliced leader RNA participates in trans-splicing as an Sm snRNP.

1990 • 42 citations

Intramolecular base pairing between the nematode spliced leader and its 5′ splice site is not essential for trans-splicing in vitro.

1991 • 39 citations

SR proteins are sufficient for exon bridging across an intron

1998 • 36 citations

Uncoupling two functions of the U1 small nuclear ribonucleoprotein particle during in vitro splicing.

1993 • 23 citations

Splicing glue: a role for SR proteins intranssplicing?

1996 • 13 citations

Uncoupling Two Functions of the U1 Small Nuclear Ribonucleoprotein Particle During in Vitro Splicing

1993 • 11 citations

In vitro trans-splicing in Saccharomyces cerevisiae.

1995 • 11 citations