SR proteins are sufficient for exon bridging across an intron

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Are snRNPs involved in splicing?

1980 • 1,206 citations

Exon Recognition in Vertebrate Splicing

1995 • 1,067 citations

Nucleotide sequence of rous sarcoma virus

1983 • 901 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

SR proteins: a conserved family of pre-mRNA splicing factors.

1992 • 766 citations

Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides

1989 • 685 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

ompT encodes the Escherichia coli outer membrane protease that cleaves T7 RNA polymerase during purification

1988 • 673 citations

Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

1994 • 622 citations

Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.

1988 • 539 citations

Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing

1993 • 407 citations

The role of exon sequences in splice site selection.

1993 • 367 citations

DYNAMIC RNA-RNA INTERACTIONS IN THE SPLICEOSOME

1994 • 356 citations

A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA

1993 • 332 citations

A single cardiac troponin T gene generates embryonic and adult isoforms via developmentally regulated alternate splicing.

1985 • 305 citations

A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding.

1993 • 300 citations

The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing.

1996 • 286 citations

Interaction of U2AF ⁶⁵ RS Region with Pre-mRNA of Branch Point and Promotion Base Pairing with U2 snRNA

1996 • 279 citations

Specific commitment of different pre-mRNAs to splicing by single SR proteins

1993 • 272 citations

SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex.

1994 • 267 citations

The SR protein family: pleiotropic functions in pre-mRNA splicing

1996 • 259 citations

Disruption of U8 nucleolar snRNA inhibits 5.8S and 28S rRNA processing in the Xenopus oocyte

1993 • 247 citations

Human fibronectin: cell specific alternative mRNA splicing generates polypeptide chains dfffering in the number of internal repeats

1984 • 221 citations

Short-Range DNA Looping by the Xenopus HMG-Box Transcription Factor, xUBF

1994 • 216 citations

Cloning and nucleotide sequencing of the bovine growth hormone gene

1982 • 214 citations

The Cardiac troponin T Alternative Exon Contains a Novel Purine-Rich Positive Splicing Element

1993 • 189 citations

Finding splice sites within a wilderness of RNA.

1995 • 188 citations

A Subset of SR Proteins Activates Splicing of the Cardiac Troponin T Alternative Exon by Direct Interactions with an Exonic Enhancer

1995 • 180 citations

Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity.

1995 • 133 citations

Human SR Proteins and Isolation of a cDNA Encoding SRp75

1993 • 105 citations

Distinct functions of SR proteins in recruitment of U1 small nuclear ribonucleoprotein to alternative 5' splice sites.

1995 • 102 citations

A two-step mechanism for 5' and 3' splice-site pairing

1995 • 94 citations

A 32-Nucleotide Exon-Splicing Enhancer Regulates Usage of Competing 5′ Splice Sites in a Differential Internal Exon

1995 • 93 citations

Genomic structure of the human caldesmon gene.

1992 • 92 citations

Purification of RNA and RNA-protein complexes by an R17 coat protein affinity method

1990 • 82 citations

A conserved epitope on a subset of SR proteins defines a larger family of Pre-mRNA splicing factors.

1995 • 73 citations

Enhancer-dependent interaction between 5' and 3' splice sites in trans.

1995 • 64 citations

In vitro splicing of cardiac troponin T precursors. Exon mutations disrupt splicing of the upstream intron.

1992 • 51 citations

A short 5' splice site RNA oligo can participate in both steps of splicing in mammalian extracts.

1995 • 42 citations

SR Proteins Promote the First Specific Recognition of Pre-mRNA and Are Present Together with the U1 Small Nuclear Ribonucleoprotein Particle in a General Splicing Enhancer Complex

1994 • 42 citations

Electron spectroscopic imaging of chromatic and other nucleoprotein complexes

1992 • 31 citations

A base-pairing interaction between U2 and U6 small nuclear RNAs occurs in > 150S complexes in HeLa cell extracts: implications for the spliceosome assembly pathway.

1993 • 30 citations